Results 71 to 80 of about 91,937 (143)

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source

Cross‐Species Plasticity and Divergence Under Alkaline Soil Signature Conditions Differentiating PYE From FIT Target Transcripts in the Arabidopsis thaliana Ferrome

Plant, Cell &Environment, Volume 49, Issue 9, Page 6719-6736, September 2026.
ABSTRACT Soil pH is an influential abiotic environmental factor. Here, we identify responses to central stimuli associated with calcareous alkaline soils in Arabidopsis and comparatively explore the potential of the closely related Arabidopsis halleri for addressing how plants cope with local soil pH.
Gen Yang, Hans Simon Metze, Ute Krämer
wiley   +1 more source

Microbial Oxidative Stress in Food Fermentations: A Comprehensive Review

eFood, Volume 7, Issue 4, August 2026.
Oxidative stress has a dual role in food fermentations: low ROS supports adaptive signaling, whereas excessive ROS causes cellular damage and process inhibition. Managing redox state as a controllable process variable can improve fermentation robustness and final food quality.
Wanrong Hu, Manxi Wu, Hui Xu, Jiebiao Chen, Wen Cai, Han Yang, Hujing Cao, Xinlin Huang, Jinping Cao, Chongde Sun, Yue Wang, Dongliang Li   +11 more
wiley   +1 more source

Overexpression of Methionine-\u3ci\u3eR\u3c/i\u3e-Sulfoxide Reductases Has No Influence on Fruit Fly Aging [PDF]

, 2009
Methionine sulfoxide reductases (Msrs) are enzymes that repair oxidized methionine residues in proteins. This function implicated Msrs in antiox¬idant defense and the regulation of aging.
Kabil, Hadise, Shchedrina, Valentina A., Lee, Byung Cheon, Harshman, Lawrence G., Gladyshev, Vadim N., Vorbrüggen, Gerd, Kim, Hwa-Young   +6 more
core  

Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases-3

, 2011
Copyright information:Taken from "Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases"BMC Molecular Biology 2006;7():11-11.Published online 16 Mar 2006PMCID:PMC1431549.oxes indicate exons, which are ...
Vadim N Gladyshev (8100), Hwa-Young Kim (12128)   +1 more
core   +1 more source

Overexpression of plastidial thioredoxins f and m differentially alters photosynthetic activity and response to oxidative stress in tobacco plants

Frontiers in Plant Science, 2013
Plants display a remarkable diversity of thioredoxins (Trxs), reductases controlling the thiol redox status of proteins. The physiological function of many of them remains elusive, particularly for plastidial Trxs f and m, which are presumed based on ...
Pascal eREY, Ruth eSANZ-BARRIO, Gilles eINNOCENTI, Brigitte eKSAS, Agathe eCOURTEILLE, Dominque eRUMEAU, Emmanuelle eISSAKIDIS-BOURGUET, Immaculada eFARRAN   +7 more
doaj   +1 more source

Reversible Oxidation of a Conserved Methionine in the Nuclear Export Sequence Determines Subcellular Distribution and Activity of the Fungal Nitrate Regulator NirA.

PLoS Genetics, 2015
The assimilation of nitrate, a most important soil nitrogen source, is tightly regulated in microorganisms and plants. In Aspergillus nidulans, during the transcriptional activation process of nitrate assimilatory genes, the interaction between the ...
Andreas Gallmetzer, Lucia Silvestrini, Thorsten Schinko, Bernd Gesslbauer, Peter Hortschansky, Christoph Dattenböck, María Isabel Muro-Pastor, Andreas Kungl, Axel A Brakhage, Claudio Scazzocchio, Joseph Strauss   +10 more
doaj   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

DNA Methylation Shapes Seed‐Borne Microbiome and Proteome Responses During Early Maize‐Beneficial Bacteria Interactions

Plant, Cell &Environment, Volume 49, Issue 8, Page 5477-5496, August 2026.
ABSTRACT Microorganism and plant interactions are crucial for development and environmental adaptation. Plant growth promoting bacteria enhance agricultural productivity in a sustainable manner, while epigenetic modifications such as DNA methylation regulate gene expression and adaptive responses.
Pedro Igor Zocateli, Geovanna Vitória Olímpio, Felipe Astolpho de Almeida, Letícia Oliveira da Rocha, Diego Vinicius de Sena Martins, Sara Sangi, Fábio Lopes Olivares, Elyabe Monteiro de Matos, Juliana Siqueira, Lyderson Facio Viccini, Roberta Pena da Paschoa, Vanildo Silveira, Clícia Grativol   +12 more
wiley   +1 more source

Methionine Sulfoxide Reduction and the Aging Process

, 2007
Aging has been described for multicellular and asymmetrically dividing organisms, but the mechanisms are poorly understood. Oxidation of proteins is considered to be one of the major factors that leads to aging.
Gladyshev, Vadim N., Koç, Ahmet
core   +2 more sources