Results 71 to 80 of about 286,324 (269)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

A Derivation of the Nonlocal Volume-Averaged Equations for Two-Phase Flow Transport

Science and Technology of Nuclear Installations, 2012
In this paper a detailed derivation of the general transport equations for two-phase systems using a method based on nonlocal volume averaging is presented.
Gilberto Espinosa-Paredes
doaj   +1 more source

Asymptotical estimation of oscillatory integral

Lietuvos Matematikos Rinkinys, 2009
The oscillatory integral is important for averaging of weakly nonlinear differential systems. Uniformly valid for parameters estimation of the integral can be use for substantiation of averaging method for wave interaction modelling.
Aleksandras Krylovas
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Within-project and cross-project defect prediction based on model averaging

Scientific Reports
Software defect prediction has an important impact on the national economy and financial service industry. Discovering defective modules in the early stage of software development has great significance.
Tong Li, Zhong Wang, Peibei Shi
doaj   +1 more source

Research on the error averaging effect of linear feed systems for precision machine tool

Ain Shams Engineering Journal
This paper presents a general and systematic approach for geometric error simulation modeling of machine tools due to the geometric errors arising from manufacturing and assembly, the error averaging mechanism of the linear feed system is investigated by
Guangming Sun, Siqi Chen, Mingze Sun, Rui Gao, Dawei Zhang, Xin Guo, Jian Zhao   +6 more
doaj   +1 more source

Averaging Methods for Design of Spacecraft Hysteresis Damper

Mathematical Problems in Engineering, 2013
This work deals with averaging methods for dynamics of attitude stabilization systems. The operation of passive gravity-gradient attitude stabilization systems involving hysteresis rods is described by discontinuous differential equations. We apply recently developed averaging techniques for discontinuous system in order to simplify its analysis and to
Ricardo Gama, Anna D. Guerman, Ana Seabra, Georgi V. Smirnov   +3 more
openaire   +2 more sources