Results 81 to 90 of about 852,854 (246)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
IEEE Access, 2018 Aggregation of intuitionistic fuzzy information is a hot topic in Atanassov's intuitionistic fuzzy set theory, which has attracted much interest from researchers in recent years. In this paper, a series of new aggregation operators and weighted averaging
Cheng-Li Fan +4 more
doaj +1 more source
Short-time homomorphic wavelet estimation
, 2013 Successful wavelet estimation is an essential step for seismic methods like impedance inversion, analysis of amplitude variations with offset and full waveform inversion.
Herrera R van der Baan M +6 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Second order accurate distributed eigenvector computation for extremely large matrices
, 2009 We propose a second-order accurate method to estimate the eigenvectors of extremely large matrices thereby addressing a problem of relevance to statisticians working in the analysis of very large datasets.
d'Aspremont, Alexandre +1 more
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Sensors, 2018 A probabilistic method to remove the random telegraph signal (RTS) noise and to increase the signal level is proposed, and was verified by simulation based on measured real sensor noise.
Haruki Ishida +7 more
doaj +1 more source
Relationship between the methods of bounding time averages
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2022 The problem of finding bounds of time-averaged characteristics of dynamical systems, such as the bound on the mean energy dissipation rate in a turbulent flow governed by incompressible Navier–Stokes equations, is considered. It is shown that the direct method described by Seis (2015 J. Fluid Mech. 777 ,
openaire +4 more sources