Results 51 to 60 of about 694,961 (287)

HYBRID METHODOLOGY OF NONLINEAR GOAL PROGRAMMING

open access: yesActa Economica, 2003
What we demonstrate here is a nonlinear goal-programming (NLCP) algorithm based on original hybrid connection of the modified simplex method of goal programming, gradient method of feasible directions and method of optimal displacement size finding ...
Лазо Рољић, PhD
doaj  

Quantum limit in a quasi-one-dimensional conductor in a high tilted magnetic field

open access: yes, 2017
Recently, we have suggested Fermi-liquid - non-Fermi-liquid angular crossovers which may exist in quasi-one-dimensional (Q1D)conductors in high tilted magnetic fields [see A.G. Lebed, Phys. Rev. Lett.
Lebed, Andrei G.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

A Steepest Feasible Direction Method for Linear Programming. Derivation and Embedding In the Simplex Method [PDF]

open access: yesOperations Research and Decisions
A feasible direction method for linear programming has been proposed. The method is embedded in the framework of the simplex method, even though it works with non-edge feasible directions.
Biressaw C. Wolde, Torbjörn Larsson
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Exploring chances and limitations of high resolution 3D-printing for guided water percolation in gas diffusion layers of polymer electrolyte fuel cells

open access: yesInterPore Journal
In polymer electrolyte fuel cells (PEFC), the design of the porous materials is of significant interest due to their crucial role in determining the cell performance.
Tim Dörenkamp   +3 more
doaj   +1 more source

A passive wireless surface acoustic wave sensor for pillar load measurement

open access: yesAIP Advances, 2019
This paper presents a passive wireless pillar load measurement method based on surface acoustic wave (SAW) technology. A strain transfer mechanical structure was designed, and the strain distribution of an elastic substrate was analyzed using elastic ...
Yanping Fan   +5 more
doaj   +1 more source

Optimal Unit Commitment by Considering High Penetration of Renewable Energy and Ramp Rate of Thermal Units-A case study in Taiwan

open access: yesApplied Sciences, 2019
When large amounts of wind power and solar photovoltaic (PV) power are integrated into an independent power grid, the intermittent renewable energy destabilizes power output.
Shiue-Der Lu   +4 more
doaj   +1 more source

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