Results 61 to 70 of about 694,961 (287)

A two-stage adaptive penalty method based on co-evolution for constrained evolutionary optimization

Complex & Intelligent Systems, 2023
Penalty function method is popular for constrained evolutionary optimization. However, it is non-trivial to set a proper penalty factor for a constrained optimization problem.
Bing-Chuan Wang, Jing-Jing Guo, Pei-Qiu Huang, Xian-Bing Meng   +3 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Preliminary study of feasibility of surface-guided radiotherapy with concurrent tumor treating fields for glioblastoma: region of interest

Radiation Oncology
Objective To evaluate the impact of the residual setup errors from differently shaped region of interest (ROI) and investigate if surface-guided setup can be used in radiotherapy with concurrent tumor treating fields (TTFields) for glioblastoma.
Jiajun Zheng, Geng Xu, Wenjie Guo, Yuanyuan Wang, Jianfeng Wu, Dan Zong, Boyang Ding, Li Sun, Xia He   +8 more
doaj   +1 more source

Strengthening seismically vulnerable reinforced concrete flat plate‐column connections by installing wing walls

Japan Architectural Review, 2021
This study emphasizes a new strengthening scheme for seismically vulnerable flat plate‐column connections in existing structures. An experimental investigation on a series of three half‐scaled interior plate‐column connections was conducted to explore ...
H. M. Golam Samdani, Susumu Takahashi, Rokhyun Yoon, Yasushi Sanada   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Component-level Resistance Characteristic Prediction Method for Marine Gas Turbine Intake Systems Based on a Neural Network Model [PDF]

Journal of Applied Fluid Mechanics
In order to improve the accuracy and efficiency of resistance characteristic prediction of marine gas turbine intake system, a resistance characteristic prediction method based on component-level numerical simulation and neural network model is proposed ...
J. Dai, Z. Xu, Y. Yuan, Y. He, R. Wang, J. Zhu, Z. Wang   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Gliding Footprint Calculation Method for Aircraft with Thrust Failure Based on Six-Degree-of-Freedom Flight Envelope and Back-Propagation Artificial Neural Network

Aerospace
In hostile environments, engine damage is of particular concern since the engine is the only component to generate thrust that affects survivability.
Zhiwei Chen, Yuxue Ge, Jie Yuan, Yang Pei   +3 more
doaj   +1 more source

An assessment of airfoil design by numerical optimization [PDF]

A practical procedure for optimum design of aerodynamic shapes is demonstrated. The proposed procedure uses an optimization program based on the method of feasible directions coupled with an analysis program that uses a relaxation solution of the ...
Hicks, R. M., Murman, E. M., Vanderplaats, G. N.   +2 more
core   +1 more source

Experimental investigation of an interior search method within a simple framework [PDF]

, 1986
A steepest gradient method for solving Linear Programming (LP) problems, followed by a procedure for purifying a non-basic solution to an improved extreme point solution have been embedded within an otherwise simplex based optimiser.
Mitra, G, Tamiz, M, Yadeger, J
core