Results 251 to 260 of about 8,171,446 (309)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Improving Methodological Quality in Meta-Analyses of Athlete Pain Interventions: An Overview of Systematic Reviews. [PDF]

Healthcare (Basel)
Pineda-Escobar S, García-Muñoz C, Villar-Alises O, Martinez-Calderon J.   +3 more
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Endometrial microbiota-targeted therapies for chronic endometritis-associated recurrent implantation failure and their impact on IVF outcomes: A systematic review and methodological quality assessment. [PDF]

Acta Obstet Gynecol Scand
Doroftei B, Ilie OD, Dabuleanu Cretu AM, Selaru I, Lunguleac G, Doroftei M, Ilea C.   +6 more
europepmc   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

The Sport Publication Observational Research Tool (SPORT): An Objective Tool to Score the Methodological Quality of Observational Clinical Sports Medicine Research. [PDF]

Orthop J Sports Med
Kuhn AW, Inclan PM, Haider AA, Christy MN, Dunn WR, Alberton L, Allen C, Anderson K, Andrews J, Azar F, Baer G, Banffy M, Bedi A, Brockmeier S, Brophy R, Bush-Joseph C, Carey J, Carter T, Cohen S, Farrow L, Flanigan D, Franklin C, Hame S, Ioannis T, Joseph S, Kenter K, Koh J, Krych A, LeClere L, Lee C, Levy B, McAllister D, Medvecky M, Morganti C, Musahl V, Nelson B, Noyes F, Owens B, Pace L, Paulos L, Redler L, Rodeo S, Safran M, Savoie F, Shelbourne D, Sherman S, Singer K, Smith M, Sonnery-Cottet B, Spiker A, Stuart M, Warren R, Wittstein J, Wolcott M, Wright R, Matava MJ.   +55 more
europepmc   +1 more source

Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality. [PDF]

Front Med (Lausanne)
Li R, Wu L, Wu X, Fu Q, Xu M, Zhai X, Chen J.   +6 more
europepmc   +1 more source

Methodological Quality of Systematic Reviews on Treatments for Gastric Cancer: A Cross-Sectional Study.

Dig Surg
Zhang Y, Wang BH, Cheng BZZ, Zhong CCW, Ho F, Chung VCH.   +5 more
europepmc   +1 more source

Top 50 Most-Cited Articles on Tension Band Wiring for Patellar Fractures: A Bibliometric Analysis and Methodological Quality Assessment. [PDF]

Cureus
Zainy A, Lee CH, Sadik H, Qiao G.
europepmc   +1 more source

Exploring the methodological quality and risk of bias in 200 systematic reviews: A comparative study of ROBIS and AMSTAR-2 tools. [PDF]

Res Synth Methods
Lunny C, Jain N, Nazari T, Kosaner-Kließ M, Santos L, Goodman I, Osman AAM, Berrone S, Dadam MN, Brenna CTA, Hussein H, Dahdal G, Cespedes A D, Ferri N, Kanji S, Chi Y, Pieper D, Shea B, Parker A, Neupane D, Khan PA, Rangira D, Kolaski K, Ridley B, Berour A, Sun K, Hamidi Rad R, Ouyang Z, Reid EK, Pérez-Neri I, Barakat SO, Bargeri S, Gianola S, Castellini G, Whitelaw S, Stevens A, Kolekar SB, Wong K, Major P, Bagheri E, Tricco AC.   +40 more
europepmc   +1 more source