Results 61 to 70 of about 1,680,347 (310)

Interventions for treating pain and disability in adults with complex regional pain syndrome - An overview of systematic reviews [PDF]

, 2013
This article is available open access through the publisher’s website at the link below. Copyright © 2013 The Cochrane Collaboration.Background - There is currently no strong consensus regarding the optimal management of complex regional pain syndrome ...
Marston, L, McAuley, J, Moseley, GL, O’Connell, NE, Wand, BM   +4 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Evaluating methodological quality of Prognostic models Including Patient-reported HeAlth outcomes in oncologY (EPIPHANY): A systematic review protocol [PDF]

, 2018
Introduction While there is mounting evidence of the independent prognostic value of patient-reported outcomes (PROs) for overall survival (OS) in patients with cancer, it is known that the conduct of these studies may hold a number of methodological ...
Anota, Amélie, Collins, Gary S., Cottone, Francesco, Deliu, Nina, Efficace, Fabio   +4 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Natural product extracts for ischemic stroke: a methodological evaluation and meta-epidemiological analysis

Frontiers in Pharmacology
BackgroundDespite numerous systematic reviews (SRs) and meta-analyses (MAs) on natural product extracts (NPEs) for ischemic stroke, their methodological limitations and redundancy are unquantified, and the impact of the Preferred Reporting Items for ...
Sijin Wang, Minghui Zhang, Yao Lu, Peipei Du, Ziwen Xu, Xu Pang, Jierong Gao, Li Li, Chi Zhang, Chi Zhang   +9 more
doaj   +1 more source

Methodological quality checklist for studies based on observational methodology (MQCOM)

Psicothema, 2019
No existing instrument addresses the minimum number of items that guarantee methodological quality in studies based on observational methodology. Consequently, professionals who are not experts in observational methodology do not have a basic framework to guide their practice in this type of study.
Chacón Moscoso, Salvador, Anguera Argilaga, María Teresa, Sanduvete Chaves, Susana, Losada López, José Luis, Lozano Lozano, José A., Portell Vidal, Mariona   +5 more
openaire   +6 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Shift in methodology and population census quality [PDF]

Statistics in Transition new series, 2016
The article refers to the shift in methods to conduct a population census: from a conventional enumeration through a sample survey and a mixed approach to administrative data, as a new standard in statistics. The paper compares two Polish censuses of 2002 and 2011.
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Protocol for a Meta-Review on Education Meta-Analyses: Exploring Methodological Quality and Potential Significance for Research Use in Practice

Nordic Journal of Systematic Reviews in Education
This protocol presents the planned methods and procedures for a meta-review that explores the methodological quality of education meta-analyses and their potential significance for research use.
Marta Pellegrini, Terri Pigott, Caroline Sutton Chubb, Elizabeth Day, Natalie Pruitt, Hannah F. Scarbrough   +5 more
doaj   +1 more source