Results 161 to 170 of about 2,951,798 (263)

A One Health investigation of a Crimean-Congo Hemorrhagic fever outbreak reveals high seropositivity in livestock in Lyantonde District, Uganda, 2024. [PDF]

One Health
Nyakarahuka L, Mulei S, Whitmer SL, Mutesi J, Baluku J, Torach CR, Namanya D, Tumusiime A, Kyondo J, Telford CT, Schuh A, Montgomery JM, Lutwama JJ, Balinandi SK, Shoemaker TR.   +14 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Outcomes of Endoscopic Single-Gated Compared to Multigated Approach using Lumen Apposing Metal Stents in the Management of Necrotizing Pancreatitis. [PDF]

Endosc Int Open
Mohammed A, Hussain A, Ji H, Singh G, Mian A, Dai SC, Avila P, Gonzaga ER, George J, Hayat M, Jain D, Yang D, Kadkhodayan K, Cosgrove N, Bilal M, Khan H, Hasan MK, Kouanda A, Arain MA.   +18 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

High Densities of Large Herbivores Rapidly Disrupt Ecosystem Integrity. [PDF]

Glob Chang Biol
Isla J, Serrano E, Calleja JA, Hernández-Castellano C, Alcalá-Herrera R, Albanell E, Alonso C, Baraza E, Brolly M, Burnside N, Burón-Ugarte A, Capó M, Cardells J, Carvalho J, Cuerdo M, Del Olmo DG, Espadaler X, Filella I, Fuentes-Moyano L, Gambra D, Gómez A, Krumins JA, Lavín-González S, Lizana V, López-Sánchez A, Martínez-Jauregui M, Martínez-Torres H, Parra-Quesada E, Peláez M, Peñuelas J, Rello C, Renedo J, Rodríguez-Vigal C, Rossa M, Miguel AS, Torres-Blas I, Valladares-Pérez D, Wenzel-Vergas JC, Perea R.   +38 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source