Results 111 to 120 of about 2,753,696 (263)
Obituary: Steve Watts (25 July 1947 - 21 March 2016)
EXARC Journal, 2017 I first met Steve in the summer of 1990. I was a student at University of North Carolina at Charlotte (UNCC) following a summer course in anthropology called Southeastern Indians.
Doug Meyer
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
EXARC Journal, 2017 This book is a rewrite of Evis’ PhD thesis compiled between October 2010 and March 2014 at Bournemouth University (University of Exeter 2017). The study was an evaluation of the archaeological excavation methods and recording systems used in the United ...
Ceilidh Lerwick
doaj
Starch and Glycogen Analyses: Methods and Techniques. [PDF]
Biomolecules, 2020 Brust H, Orzechowski S, Fettke J.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Some Uses of Experiment for Understanding Early Knitting and Erasmus' Bonnet
EXARC Journal, 2018 Of Erasmus, prince of humanists (1466?-1536), no less than eight portraits from life survive – all eight in the exact same bonnet. A recently published investigation of this iconic garment (Kruseman, Sturtewagen and Malcolm-Davies, 2016) involved ...
Geeske M. Kruseman
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Reconstructing Textile Cleaning in the Ancient Roman Fullonicae
EXARC JournalThis project experimentally reconstructs textile cleaning in the ancient Roman fullonicae. White wool fabric was stained with olive oil, soil, wine, and tomato-based sauce to approximate the everyday soiling of Roman garments.
Kaira Shlipak
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source