Results 81 to 90 of about 2,753,696 (263)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

A CURE for Teaching Experimental Archaeology

EXARC Journal
This paper explores the ‘Course-based Undergraduate Research Experience’ (CURE) model as an effective approach to teaching experimental archaeology. While the CURE model has been successfully used in STEM fields to enhance student engagement and produce ...
Shelby S. J. Putt
doaj  

A look into retinal organoids: methods, analytical techniques, and applications. [PDF]

Cell Mol Life Sci, 2021
Afanasyeva TAV, Corral-Serrano JC, Garanto A, Roepman R, Cheetham ME, Collin RWJ.   +5 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

The Transformation of Glass Debris from Apollonia-Arsuf (Byzantine Sozousa)

EXARC Journal
The site of Apollonia-Arsuf (Byzantine Sozousa) is located on the Mediterranean coast, some 17 km north of Jaffa (Joppa) and 34 km south of Caesarea Maritima, Israel.
Oren Tal, Ruth E. Jackson-Tal, Dafna Kaffeman   +2 more
doaj  

Methods and techniques for in vitro subcellular localization of radiopharmaceuticals and radionuclides. [PDF]

Nucl Med Biol, 2021
Costa IM, Cheng J, Osytek KM, Imberti C, Terry SYA.   +4 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The Rolling Flange Hypothesis: A Mechanical Reinterpretation of Trilithon Block Movement at Baalbek

EXARC Journal
The transport of the c. 800-tonne trilithon blocks at Baalbek remains an unresolved challenge within Near Eastern archaeology. Existing hypotheses - including sledges, rollers, earth ramps, and large-scale manpower organisation - struggle to reconcile ...
Anthony Scavo
doaj  

Technical Elements for Etruscan-Padan Kilns Firing and Female Labour Connected to These Tools

EXARC Journal, 2012
This article presents work connected to the GestiRitrovati project, the association that performs archaeological experiments at the Forcello Archaeological Park (Mn).
Francesca Caresani
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source