Results 111 to 120 of about 896,359 (265)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical decision making: its relation with critical thinking

Journal of Holistic Nursing and Midwifery, 2008
Introduction: Clinical decision making as a fundamental part of nursing profession effects ‎quality of nursing care the most. Nurse as a clinical decision maker uses critical thinking in ‎providing proficient care. Evaluation of data and choosing
nazyla javadi, ezat paryad, kolsoum fadakar, zahra atarkar ruoshan, shahla asiri   +4 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The effect of decision making skill training on perception of clinical decision making of nursing student

Development Strategies in Medical Education, 2015
Introduction: The aim of education to nursing student is to help them to acquire knowledge, skill and attitudes which they need to overcome on clinical decision making. The purpose of this study was to examine effects of decision making skill training on
Razeieh Beighi, Sameireh Abedini
doaj  

Factors influencing multidisciplinary clinical decision-making in the critical care unit: a systematic review and mixed-methods meta-synthesis

BJA Open
Background: The intensive care unit (ICU) is a dynamic environment that necessitates daily clinical decisions regarding organ support treatments. The decision-making process varies significantly between clinicians (i.e.
Kenki Matsumoto, Brigitta Fazzini, Hannah Malcolm, Jack Eldridge, Zudin Puthucheary, Magda Osman, Timothy J. Stephens   +6 more
doaj   +1 more source

Treatment Changes Clinical Significance Method: Properties, Calculation Method, Decision Making and Limitations

روانشناسی بالینی و شخصیت, 2014
Statistical significant methods are usually used to evaluate the effectiveness of the psychological treatments however, these methods have a number of inherent limitations. In fact, significant differences between the pre-treatment and post-treatment scores of patients per se do not necessarily indicate that the patients have reached the level of ...
M.A Asghari Moghaddam, M.R Shairi
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Experiences and Clinical Decision-making of Operating Room Nurses Based on Benner’s Theory

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: Clinical decision-making is fundamental for professional nurses, which establishes professional identity. Given the importance of clinical decision-making for perioperative nurses, this study aimed to investigate nurses ...
A Arzani, M Lotfi, AR Abedi
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source