Results 51 to 60 of about 254,817 (266)
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Managements of different types of conflicts in creative collective [PDF]
Marketing i Menedžment Innovacij, 2012 In article concept of conflicts arising in creative collective and work of advertisers with advertising agencies is considered, analysis of conflicts nature of, their classification and overcoming methods is carried out.
T.О. Bashuk, M.O. Khyzhnyak
doaj
INNOVATION RESISTANCE AND METHODS OF OVERCOMING IT
This article presents the impact and importance of innovation on economic prosperity. The concept of resistance to innovation and the role of inertia in the innovation process are analyzed. The innovation process is discussed not only from the perspective of technical or technological changes but also from the perspective of institutional ...
Kutbedinov, Farhod, Niyatova, Iroda
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
CAUSES OF SOCIO-ECONOMIC CONFLICTS IN CUSTOMS AND METHODS OF OVERCOMING THEM
Вестник университета, 2016 The article discusses the concept of the school of human relations as tool for solving situations conflict in the customs authorities. Provides statistics on the results of analysis of the socio-economic conflicts.
A. Andrianov, V. Ovchinnikova
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
CAUSES OF SOCIO-ECONOMIC CONFLICTS IN CUSTOMS AND METHODS OF OVERCOMING THEM
Вестник университета, 2019 The article discusses the concept of the school of human relations as tool for solving situations conflict in the customs authorities. Provides statistics on the results of analysis of the socio-economic conflicts.
A. Andrianov, V. Ovchinnikova
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source