Results 61 to 70 of about 254,817 (266)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Overcoming the Limits of Cross-Sensitivity: Pattern Recognition Methods for Chemiresistive Gas Sensor Array

Nano-Micro Letters
Highlights The types, working principles, advantages and limitations of pattern recognition methods based on chemiresistive gas sensor array are reviewed and discussed comprehensively.
Haixia Mei, Jingyi Peng, Tao Wang, Tingting Zhou, Hongran Zhao, Tong Zhang, Zhi Yang   +6 more
doaj   +1 more source

Creative Methods of Overcoming Stress: a Comparative Analysis of Various Approaches in Psychological Counselling/ Psychotherapy

Теоретическая и экспериментальная психология
Background. In the modern geopolitical situation, Russians increasingly show symptoms of life stress, which causes an increase in anxiety and depressive states, and the need for ecologic and effective forms of self-help, psychocorrection, psychological ...
Tatiana A. Popova
doaj   +1 more source

APPLICATION OF ANALYTICAL EXERCISES AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION FOR STATIC, DYNAMIC BALANCE AND POSTURAL CONTROL IMPROVEMENT [PDF]

Journal of IMAB
Purpose: to assess the recovery of static, dynamic balance and postural control while overcoming muscle imbalance after an anterior cruciate ligament reconstruction by applying analytical exercises.
David Kantchev, Gergana Nenova, Altsek Naydenov, Elena Zheleva, Vanina Mihailova-Alakidi   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Unlocking Success: Overcoming the Impact of Variation Orders on SMEs Using Modern Methods of Construction

Buildings
Construction project delays remain a persistent issue, often exacerbated by variation orders that adversely affect both financial and environmental performance, even in the UK. Although Modern Methods of Construction (MMC) have been increasingly employed
Hafiz Muhammad Mubashar, Anushika Ekanayake, David J. Edwards, Akila Rathnasinghe, Agana Parameswaran   +4 more
doaj   +1 more source

Methods to overcome vaccine hesitancy [PDF]

The Lancet, 2019
Rajasekharan K, Nayar, Anoop T, Nair, Muhammed, Shaffi, Kamala, Swarnam, Anant, Kumar, Minu, Abraham, Jinbert, Lordson, Chitra, Grace   +7 more
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A Method for Overcoming ‘Unsoundness’ in Magnesian Limes [PDF]

Nature, 1952
BUILDING failures arising from the use of limes with a high content of magnesia have frequently been observed. These failures—such as spalling and blistering of plaster coats, disintegration of mortar joints and expansion of brickwork—are, according to Wells and others1,2, caused by the slow hydration of the magnesia in these ‘unsound’ limes, and may ...
openaire   +1 more source