Results 61 to 70 of about 241,169 (264)

CAUSES OF SOCIO-ECONOMIC CONFLICTS IN CUSTOMS AND METHODS OF OVERCOMING THEM

Вестник университета, 2019
The article discusses the concept of the school of human relations as tool for solving situations conflict in the customs authorities. Provides statistics on the results of analysis of the socio-economic conflicts.
A. Andrianov, V. Ovchinnikova
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Overcoming the Limits of Cross-Sensitivity: Pattern Recognition Methods for Chemiresistive Gas Sensor Array

Nano-Micro Letters
Highlights The types, working principles, advantages and limitations of pattern recognition methods based on chemiresistive gas sensor array are reviewed and discussed comprehensively.
Haixia Mei, Jingyi Peng, Tao Wang, Tingting Zhou, Hongran Zhao, Tong Zhang, Zhi Yang   +6 more
doaj   +1 more source

Unlocking Success: Overcoming the Impact of Variation Orders on SMEs Using Modern Methods of Construction

Buildings
Construction project delays remain a persistent issue, often exacerbated by variation orders that adversely affect both financial and environmental performance, even in the UK. Although Modern Methods of Construction (MMC) have been increasingly employed
Hafiz Muhammad Mubashar, Anushika Ekanayake, David J. Edwards, Akila Rathnasinghe, Agana Parameswaran   +4 more
doaj   +1 more source

APPLICATION OF ANALYTICAL EXERCISES AFTER ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION FOR STATIC, DYNAMIC BALANCE AND POSTURAL CONTROL IMPROVEMENT [PDF]

Journal of IMAB
Purpose: to assess the recovery of static, dynamic balance and postural control while overcoming muscle imbalance after an anterior cruciate ligament reconstruction by applying analytical exercises.
David Kantchev, Gergana Nenova, Altsek Naydenov, Elena Zheleva, Vanina Mihailova-Alakidi   +4 more
doaj   +1 more source

Methods to overcome vaccine hesitancy [PDF]

The Lancet, 2019
Rajasekharan K, Nayar, Anoop T, Nair, Muhammed, Shaffi, Kamala, Swarnam, Anant, Kumar, Minu, Abraham, Jinbert, Lordson, Chitra, Grace   +7 more
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source