Results 31 to 40 of about 2,552 (122)

Ketamine and Esketamine in Clinical Trials: FDA‐Approved and Emerging Indications, Trial Trends With Putative Mechanistic Explanations

open access: yesClinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 374-386, February 2025.
Ketamine has a long and very eventful pharmacological history. Its enantiomer, esketamine ((S)‐ketamine), was approved by the US Food and Drug Administration (FDA) and EMA for patients with treatment‐resistant depression (TRD) in 2019. The number of approved indications for ketamine and esketamine continues to increase, as well as the number of ...
Ksenia A. Vekhova   +3 more
wiley   +1 more source

Childhood maltreatment and outcomes following electroconvulsive therapy in adults with depression

open access: yesActa Psychiatrica Scandinavica, Volume 151, Issue 1, Page 46-55, January 2025.
Abstract Objective Childhood maltreatment is associated with less favourable treatment outcomes with pharmacotherapy and psychotherapy for depression. It is unknown whether this increased risk of treatment resistance in maltreated individuals extends to electroconvulsive therapy (ECT).
Ana Jelovac   +5 more
wiley   +1 more source

Reversible Focal Ischemia in the Rat: Effects of Halothane, Isoflurane, and Methohexital Anesthesia

open access: yes, 1991
Barbiturates and the volatile anesthetic isoflurane reduce CMR to similar values. If the mechanism of barbiturate protection against focal ischemic injury is due to a reduction in cellular energy requirements, then isoflurane should similarly reduce ...
Jiegang Zhou   +3 more
core   +1 more source

Pharmacological Postoperative Pain Management for Paediatric Dental Extractions Under General Anaesthesia: A Systematic Review

open access: yesPain Research and Management, Volume 2025, Issue 1, 2025.
General anaesthesia (GA) as a pharmacological behaviour management strategy may be indicated for dental extractions in children unable to cooperate in the dental chair. Pain is the most common postoperative complication in children following dental GA.
Emily Xin Yi Ting   +4 more
wiley   +1 more source

Effectiveness of pharmacological procedural sedation in children with autism spectrum disorder: A systematic review and meta‐analysis

open access: yesActa Paediatrica, Volume 113, Issue 11, Page 2363-2377, November 2024.
Abstract Aim Management of primary healthcare and routine minor procedures for children with autism spectrum disorder (ASD) can be challenging; therefore, when behavioural strategies fail, sedative medications are often employed. We evaluated the effectiveness of the current pharmacological strategies for managing children with ASD.
Luisa Zupin   +6 more
wiley   +1 more source

Highly Enriched Mixtures of Methohexital Stereoisomers by Palladium‐Catalyzed Allylation and Their Anaesthetic Activity

open access: yes, 2003
The stereoselective Pd-catalyzed allylation of MBA [5-(2'hex-3'-ynyl)-1-methylbarbituric acid] gives the commercial injection narcotic methohexital, which exists as four isomers: two diastereomeric pairs of enantiomers.
Lunz, Dirk   +11 more
core   +1 more source

Neuropathic pain has sex‐specific effects on oxycodone‐seeking and non‐drug‐seeking ensemble neurons in the dorsomedial prefrontal cortex of mice

open access: yesAddiction Biology, Volume 29, Issue 8, August 2024.
Oxycodone seeking was higher in females following SNI that came after the 10‐day SA timeline. A selective increase in dorsomedial prefrontal cortex pyramidal cell intrinsic excitability was detected among non‐ensemble neurons from female mice that self‐administered oxycodone and received SNI.
Bailey C. Sarka   +5 more
wiley   +1 more source

Comparison of Cardiovascular Effects of Propofol versus Sodium Thiopental Anesthesia in Children Undergoing Electroconvulsive Therapy (ECT)

open access: yesمجله دانشکده پزشکی اصفهان, 2017
Background: Seizures caused by electrical stimulation during electroconvulsive therapy (ECT) should be managed; otherwise, electroconvulsive therapy can be an unpleasant experience. Therefore, sedative short-acting drugs like sodium thiopental, propofol,
Behzad Nazemoroaya   +2 more
doaj  

What is the best treatment for hypotension in healthy dogs during anaesthesia maintained with isoflurane?

open access: yesAustralian Veterinary Journal, Volume 102, Issue 5, Page 264-273, May 2024.
Hypotension is a common and potentially life‐threatening complication of general anaesthesia in dogs. Due to the combination of cardiovascular side effects of many anaesthetic, sedative and analgesic drugs used peri‐operatively hypotension is frequently reported even in healthy dogs undergoing elective procedures.
CT Quinn
wiley   +1 more source

The Rhythm of Sedation: Comparison of Methohexital, Propofol, and Etomidate for ED Cardioversions

open access: yes
Background/Significance: Cardioversions in the emergency department (ED) allow for a controlled shock to be delivered to the heart to restore normal sinus rhythm in dysrhythmic states such as atrial fibrillation and supraventricular tachycardia.
Hajiharis, Maria, PharmD   +2 more
core   +3 more sources

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