Results 41 to 50 of about 3,558 (189)

Connections of the Mesencephalic Locomotor Region (MLR) in the Cat [PDF]

, 1980
The cat entopeduncular nucleus (EN), which is the main output of the basal ganglia, is known to project to the mesencephalic tegmentum. We have been able to elicit antidromic responses in single EN neurons from the region of the mesencephalic locomotor ...
Garcia-Rill, E., Gilmore, S. A., Skinner, Robert D.   +2 more
core   +2 more sources

General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis [PDF]

, 2011
Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a major mystery of modern medicine ...
Brown, Emery N., Purdon, Patrick Lee, Van Dort, Christa   +2 more
core   +1 more source

Dual ETA‐ETB receptor antagonism improves metabolic syndrome‐induced heart failure with preserved ejection fraction

Fundamental &Clinical Pharmacology, Volume 39, Issue 3, June 2025.
Abstract Background Metabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.
Francesca Lockwood, Marianne Lachaux, Najah Harouki, Matthieu Soulié, Lionel Nicol, Sylvanie Renet, Anaïs Dumesnil, Magali Vercauteren, Jeremy Bellien, Marc Iglarz, Vincent Richard, Paul Mulder   +11 more
wiley   +1 more source

Ketamine and Esketamine in Clinical Trials: FDA‐Approved and Emerging Indications, Trial Trends With Putative Mechanistic Explanations

Clinical Pharmacology &Therapeutics, Volume 117, Issue 2, Page 374-386, February 2025.
Ketamine has a long and very eventful pharmacological history. Its enantiomer, esketamine ((S)‐ketamine), was approved by the US Food and Drug Administration (FDA) and EMA for patients with treatment‐resistant depression (TRD) in 2019. The number of approved indications for ketamine and esketamine continues to increase, as well as the number of ...
Ksenia A. Vekhova, Eugenia D. Namiot, Jörgen Jonsson, Helgi B. Schiöth   +3 more
wiley   +1 more source

Histamine release after intravenous application of short-acting hypnotics. A comparison of etomidate, Althesin (CT1341) and propanidid [PDF]

, 1973
The subject of histamine release was investigated in 16 volunteers by means of plasma histamine determination after the administration of etornidate, Althesin, propanidid, and Cremophor EL.
Beigl, R., Bezecny, H., Doenicke, A., Kalmar, L., Lorenz, Wilfried, Mann, G., Praetorius, B., Uhlig, G.   +7 more
core  

Ascorbic acid prevents cimetidine-induced decrease of serum hydrocortisone concentrations [PDF]

, 1990
A blind, parallel, prospective, clinical study was conducted to investigate the effect of ascorbic acid on human serum hydrocortisone concentrations which were decreased by the administration of cimetidine.
Boidin, M.P. (Marinus Pieter), Erdmann, W. (Wilhelm), Stuurman, A. (Arie)   +2 more
core   +1 more source

Childhood maltreatment and outcomes following electroconvulsive therapy in adults with depression

Acta Psychiatrica Scandinavica, Volume 151, Issue 1, Page 46-55, January 2025.
Abstract Objective Childhood maltreatment is associated with less favourable treatment outcomes with pharmacotherapy and psychotherapy for depression. It is unknown whether this increased risk of treatment resistance in maltreated individuals extends to electroconvulsive therapy (ECT).
Ana Jelovac, Christopher Mohan, Emma Whooley, Anna Igoe, Cathal McCaffrey, Declan M. McLoughlin   +5 more
wiley   +1 more source

A comparative study on the effects of thiopental and ketamine, in patients under electroconvulsive therapy [PDF]

, 2009
چکیده: زمینه و هدف: دارو در بیهوشی مورد استفاده در تشنج درمانی الکتریکی (ECT) همراه با معایبی از جمله درد و تورم در محل تزریق، کوتاه بودن مدت تشنج، انقباض زودرس بطنی و برادیکاردی سینوسی هستند.
Barakatin, Majid., Hasheminia, Seyed jalal., Razavi, Mehran., Solimani, Bahram., Soltani, Hasan Ali., Yaraghi, Ahmad.   +5 more
core  

Evaluating the Contributions of State of the Art Assessment Techniques to Predicting Memory Outcome after Unilateral Anterior Temporal Lobectomy [PDF]

, 2006
Purpose:Although anterior temporal lobectomy (ATL) is an effective treatment for many patients with medically refractory temporal lobe epilepsy (TLE), one risk associated with this procedure is postsurgical decline in memory. A substantial number of past
Bingaman, William, Diehl, Beate, Lineweaver, Tara T., Morris, Harold H., Najm, Imad M., Naugle, Richard I.   +5 more
core   +2 more sources

Sodium methohexital: a clinical study [PDF]

Canadian Anaesthetists’ Society Journal, 1959
Metliohexital is the only intravenous anaesthetic agent tested by us so far which combines shorter action with a higher potency than thiopental. If dose per minute of anaesthesia for a standard procedure is taken as an indication, the relative potency of thiopental to methohexital is 1:1.54.
G M, WYANT, C A, CHANG
openaire   +2 more sources