Results 11 to 20 of about 3,558 (189)

Propofol Versus Methohexital in Electroconvulsive Therapy: Impact on Treatment Efficacy and Adverse Effects. A Systematic Literature Review and Meta-Analysis. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Electroconvulsive therapy (ECT) is a widely used treatment for depression, but the choice of the anesthetic that is used for induction may affect both clinical outcomes and the occurrence of adverse effects (AEs). Propofol and methohexital are frequently used in Finland, yet their relative impact on treatment efficacy and AEs ...
Huoponen SH, Sisa K, Saari T, Taittonen M, Ahlmén-Laiho U.   +4 more
europepmc   +2 more sources

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension. [PDF]

Compr Physiol
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Leuillier M, Chelgham M, Messaoudi H, Tu L, Ménoret S, Thuillet R, Groussard D, Lillich FF, Ottaviani M, Nicol L, Mulder P, Humbert M, Richard V, Anegon I, Morisseau C, Proschak E, Guignabert C, Bellien J.   +17 more
europepmc   +2 more sources

The human photosensitive epilepsy model for clinical proof-of-principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model. [PDF]

Epilepsia
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Löscher W, Trenité DK.
europepmc   +2 more sources

Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence‐based prediction, expert evaluation, clinical corroboration and mechanism of action analyses

Addiction, Volume 118, Issue 7, Page 1307-1319, July 2023., 2023
Abstract Background and aims Cocaine use disorder (CUD) is a significant public health issue for which there is no Food and Drug Administration (FDA) approved medication. Drug repurposing looks for new cost‐effective uses of approved drugs. This study presents an integrated strategy to identify repurposed FDA‐approved drugs for CUD treatment.
Zhenxiang Gao, T. John Winhusen, Maria Gorenflo, Udi E. Ghitza, Pamela B. Davis, David C. Kaelber, Rong Xu   +6 more
wiley   +1 more source

A systematic review of modified electroconvulsive therapy (ECT) to treat delirium

Acta Psychiatrica Scandinavica, Volume 147, Issue 5, Page 403-419, May 2023., 2023
Abstract Background Delirium is costly for patients, carers, and healthcare systems. In addition, non‐pharmacological and pharmacological management of delirium is challenging. Electroconvulsive therapy (ECT) has been proposed and used as an anecdotal treatment of delirium in clinical practice.
Katie Lupke, Nicola Warren, Andrew Teodorczuk, Sarah Steele, Uday Kolur, Anne Wand, Gail Robinson, Stephen Parker   +7 more
wiley   +1 more source

Crystal structure of the α-racemate of methohexital

Acta Crystallographica Section E: Crystallographic Communications, 2015
Molecules of the title compound, C14H18N2O3 [systematic name: 5-allyl-5-(hex-3-yn-2-yl)-1-methylpyrimidine-2,4,6(1H,3H,5H)-trione in the (RbSh)/(SbRh) racemic form], are connected by mutual N—H...O=C hydrogen bonds in which the carbonyl group at the 2 ...
Thomas Gelbrich, Ulrich J. Griesser
doaj   +1 more source

Recuperação pós-eletroconvulsoterapia: comparação entre propofol, etomidato e tiopental [PDF]

, 2008
OBJECTIVES: To compare post anesthetic time for patient recovery after electroconvulsive therapy, as measured by the post anesthetic Recovery Score of Aldrete and Kroulik, using three different types of hypnotic drugs (propofol, etomidate and thiopental).
BELEGARDE, Iara M T, BUENO, Celso R, FREGNI, Felipe, ROSA, Marina O, ROSA, Moacyr A   +4 more
core   +1 more source

The use of barbiturate-induced coma during cerebrovascular neurosurgery procedures: A review of the literature

Brain Circulation, 2015
Barbiturates are indicated for use during vascular neurosurgery procedures such as carotid surgery, arteriovenous malformation (AVM) surgery, cerebral aneurysm surgery, extracranial-intracranial bypass, and following significant bleeding due to AVMs or ...
Nathaniel R Ellens, Bryan E Figueroa, Justin C Clark   +2 more
doaj   +1 more source

Método de sedación-amnesia-anestesia con methohexital sódico durante el parto en perfusión continua gota-gota

Revista Colombiana de Obstetricia y Ginecología, 1968
Se estudian 330 pacientes parturientas a quienes se les aplicó MHS en perfusión continua gota-gota buscando en ellas producir amnesia sin que se produjeran complicaciones feto-maternas.
Julio César Tuberquia Carvajal, Flabio Yepes Grisales, Germán Ochoa Mejía   +2 more
doaj   +1 more source

Memory Performance is Related to Language Dominance as Determined by the intracarotid amobarbital procedure [PDF]

, 2009
Objective The goal of this study was to explore the relationship between language and memory lateralization in patients with epilepsy undergoing the intracarotid amobarbital procedure.
Alexopoulosa, A. V., Kovac, S., Lineweaver, Tara T., Loddenkemper, T., Möddel, G., Reinholz, J., Schuele, S. U., Syed, T.   +7 more
core   +2 more sources