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Tocilizumab Monotherapy or Combined With Methotrexate for Rheumatoid Arthritis: A Randomized Clinical Trial.

open access: yesJAMA Netw Open
Liu T   +22 more
europepmc   +1 more source
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Methotrexate

Home Healthcare Now, 2015
The purpose of this article is to educate healthcare professionals about the many uses of the drug Methotrexate. Information regarding dosing, action, contraindications, adverse effects, drug interactions, as well as tips for patient education are included.
Pile, Kevin (R17082), Graham, Garry G.
  +8 more sources

METHOTREXATE IN PSORIASIS

The Lancet, 1968
SUMMARY. Seventeen patients with widespread psoriasis were treated with parenteral methotrexate over a period of 2–88 weeks. The injections were given every 1–4 weeks, in a dose of 12·5–37·5 mg. The best results were obtained with a dose of 25 mg. of methotrexate once weekly.
Harvey Baker, TerenceJ Ryan
  +12 more sources

Pharmacokinetics of methotrexate

Clinical Pharmacology & Therapeutics, 1973
Methotrexate (Mtx) is a competitive inhibitor of the enzymatic activity of dihydrofolate reductase, decreasing the reduction of folic acid to tetrahydrofolate and thereby the activity of thymi dilate kinase. The net effect is a decrease in biosynthesis of deoxyribonucleic acid (DNA) primarily, but also of ribonucleic acid (RNA) and protein. Whereas the
D H, Huffman   +3 more
openaire   +4 more sources

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