Results 51 to 60 of about 2,424 (220)

Pharmacokinetic Evaluation of a Cinnamon Product on CYP2A6 Substrate Drugs: Application of a Novel Tool Involving the Nicotine Metabolite Ratio

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1485-1493, June 2026.
Cinnamon (Cinnamomum spp.) is used as a culinary spice and dietary supplement. A major constituent, cinnamaldehyde, was previously shown to inactivate cytochrome P450 (CYP) 2A6 in vitro. A mechanistic static model predicted an ~5‐fold increase in the AUC of the CYP2A6 substrates nicotine and letrozole.
Aiden‐Hung P. Nguyen, Deena L. Hadi, Daniel A. Todd, Preston K. Manwill, John R. White, Matthew E. Layton, Nadja B. Cech, Kenneth E. Thummel, Mary F. Paine   +8 more
wiley   +1 more source

Dynamic Rearrangement of Cell States Detected by Systematic Screening of Sequential Anticancer Treatments [PDF]

, 2017
Signaling networks are nonlinear and complex, involving a large ensemble of dynamic interaction states that fluctuate in space and time. However, therapeutic strategies, such as combination chemotherapy, rarely consider the timing of drug perturbations ...
Blicher Bjerregård, Mathias, Cox, Thomas R., Erler, Janine T., Ferkinghoff-Borg, Jesper, Koplev, Simon, Linding, Rune, Longden, James, Pedersen, Jesper T., Sommer, Morten Otto Alexander, Voellmy, Franziska   +9 more
core   +3 more sources

Pastinaca sativa L.: Nutritional Composition, Phytochemistry, and Pharmacological Properties Supporting Its Potential as a Functional Food and Therapeutic Agent

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Food‐grade processing of Pastinaca sativa (parsnip) converts a nutrient‐rich plant matrix (dietary fiber, fructans, phenolics) through washing/slicing/enzymatic treatment and ingredient preparation into functional food ingredients, including fiber concentrates, antioxidant‐rich fractions, and parsnip powders/extracts.
Somanjana Khatua, Anish Nag, Surajit Sen, Jit Sarkar, Krishnendu Acharya, Daniela Calina, William N. Setzer, Javad Sharifi‐Rad   +7 more
wiley   +1 more source

Citrus Consumption and Risk of Basal Cell Carcinoma and Squamous Cell Carcinoma of the Skin [PDF]

, 2015
Animal experiments have demonstrated the photocarcinogenic properties of furocoumarins, a group of naturally occurring chemicals that are rich in citrus products.
Cho, Eunyoung, Feskanich, Diane, Han, Jiali, Li, Wen-Qing, Qureshi, Abrar A., Sun, Qi, Wu, Shaowei   +6 more
core   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, Volume 4, Issue 2, February 2026.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines [PDF]

, 2012
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumour cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder
Campos, Ana M. F. Oliveira, Cerqueira, N. M. F. S. A., Francisco, Carla S., Rodrigues, L. R., Rodrigues, Lígia M.   +4 more
core   +1 more source

Extraction, Isolation, and Purification of Furanocoumarins from Invasive Heracleum sosnowskyi

Separations
Heracleum sosnowskyi Manden. (Sosnowsky’s hogweed), originally introduced to Central and Eastern Europe as a fodder crop, has become a highly invasive species due to its ecological adaptability, high reproductive capacity, and efficient seed dispersal ...
Vida Vickackaite, Karina Pilaityte, Vilius Poskus   +2 more
doaj   +1 more source

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells [PDF]

, 2017
The major-histocompatibility-complex-(MHC)-class-I-related molecule MR1 can present activating and non-activating vitamin-B-based ligands to mucosal-associated invariant T cells (MAIT cells). Whether MR1 binds other ligands is unknown. Here we identified
A Kurioka, AJ Corbett, AJ McCoy, AL Szymczak, Alexandra J Corbett, Andrew N Keller, Anthony W Purcell, Bronwyn S Meehan, BY Chua, Criselle D'Souza, Dale I Godfrey, David P Fairlie, DC Chatterji, DI Godfrey, E Treiner, EY Jones, F Koning, F Tilloy, HEG McWilliam, Huimeng Wang, I Kawachi, I Van Rhijn, IJ Skypala, James McCluskey, Jamie Rossjohn, JE Ussher, Jeffrey Y W Mak, L Kjer-Nielsen, L Le Bourhis, Lars Kjer-Nielsen, Ligong Liu, Lyudmila Kostenko, M Bharadwaj, M Dusseaux, M Lepore, M Salio, MC Gold, MD Winn, MHM Heemskerk, NA Gherardin, Nicholas A Gherardin, NM Davies, O Patel, P Emsley, PCD Hawkins, PD Adams, PF Fehlner, PJ Hashkes, PT Illing, R Reantragoon, R Reantragoon, Richard W Birkinshaw, S Gras, S Gras, S Huang, S Zelcer, SB Eckle, SB Eckle, Sidonia B G Eckle, SK Hoiseth, Troi Pediongco, V Krasniqi, VB Chen, VC Romão, Victoria A Hughes, Weijun Xu, WXDS Kabsch, Zhenjun Chen   +67 more
core   +2 more sources

Investigation of the Regulatory Mechanism of Huazhuo Runzao Jiangqi Formula on Esophageal Cancer Utilizing Network Pharmacology, Molecular Docking, and In Vivo and In Vitro Experiments

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Esophageal cancer, a common digestive malignant neoplasm globally, poses significant health risks. Huazhuo Runzao Jiangqi (HRJ) formula, modified from the classic “Qige Powder” with additions and reductions, has shown clear efficacy in treating esophageal cancer and precancerous lesions in clinical practice and preliminary studies ...
Yun He, Huan-Fang Fan, De-Hui Li, Zi-Hui Liu, Yi-Ting Gu, Chang-Hui Han, Pan Ma, Na Guo, Xiao Wang, Yan Han, Irfan Ahmad   +10 more
wiley   +1 more source

Recovering actives in multi-antitarget and target design of analogs of the myosin II inhibitor blebbistatin [PDF]

, 2018
In multitarget drug design, it is critical to identify active and inactive compounds against a variety of targets and antitargets. Multitarget strategies thus test the limits of available technology, be that in screening large databases of compounds vs a
García-Sosa, Alfonso T, Guedes, Rita C, Roman, Bart, Stevens, Christian   +3 more
core   +2 more sources