Results 51 to 60 of about 1,995 (182)

Phase II trial of SM-88, a cancer metabolism based therapy, in non-metastatic biochemical recurrent prostate cancer [PDF]

, 2021
Background Androgen deprivation therapy (ADT) is a standard treatment for high-risk biochemically-recurrent, non-metastatic prostate cancer (BRPC) but is not curative and associated with toxicity.
Benjamin A. Gartrell, Mack Roach, Sokol, Gerald H, Scher, Howard I, Roach, Mack, Avi Retter, Howard I. Scher, Del Priore, Giuseppe, Gerald H. Sokol, Giuseppe Del Priore, Gartrell, Benjamin A, Retter, Avi   +11 more
core   +1 more source

Introducing the Cis‐2,3‐Bis(trifluoromethyl)cyclopropyl Chemotype: Late‐Stage Installation and Stereoelectronic Properties

ChemistryEurope, Volume 4, Issue 2, February 2026.
The cis‐2,3‐bis(trifluoromethyl)cyclopropyl chemotype is introduced. The steric demand of this motif is intermediate between that of the heptafluoroisopropyl and prefluorotertbutyl groups; yet, it induces significantly less lipophilicity than these due to its facial polarity.
Daniel Gaviña, Zeyu Feng, David Herrero, Martin Simon, Christopher Golz, Manuel Alcarazo   +5 more
wiley   +1 more source

Rat Liver Cytochrome P450-mediated Metabolic Activation of Methoxsalen and Structurally Related Compounds and its Relation to Enzyme Inhibition

, 1995
The metabolic activation and enzyme inhibition characteristics of methoxsalen were investigated in rat liver microsomes obtained from untreated animals and those treated with a number of prototypic inducers of cytochrome P450.
David J Wilkinson, Jeffrey R Fry
core   +1 more source

Analysis of the possible therapeutic use of CYP2A6 inhibition with methoxsalen in smoking cessation [PDF]

, 2001
grantor: University of TorontoSmokers smoke to adjust their nicotine concentrations within a desired range. Since CYP2A6 is responsible for most of nicotine's metabolism to cotinine, use of a CYP2A6 inhibitor such as methoxsalen could have ...
Dortok, E. Desiree
core   +1 more source

Melanocyte transplantation to skin prepared by controlled PUVA-induced sunburn-like blistering for vitiligo treatment – A pilot clinical trial

Journal of the Formosan Medical Association
Vitiligo is a common acquired disease of pigment loss. In lesions recalcitrant to non-invasive treatment, transplantation of cultured autologous melanocytes is an emerging choice.
Po-Hua Chen, Sabrina Mai-Yi Fan, Bin-Ru She, Yi-Ping Wu, Hsiang-Chun Hsu, Ying-Jung Yang, Jun-Jae Huang, Shu-Fen Yeh, Yi-Chen Chen, Pei-Ju Lin, Wann-Hsin Chen, Hsien-Ching Chiu, Hsin-Su Yu, Chih-Ching Liao, Sung-Jan Lin   +14 more
doaj   +1 more source

Synthetically Modified Methoxsalen for Enhanced Cytotoxicity in Light and Dark Reactions

Bioorganic & Medicinal Chemistry Letters, 2018
Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases.
C. Guillon, Y. Jan, N. Foster, J. Ressner, D. E. Heck, J. Laskin, N. Heindel   +6 more
semanticscholar   +1 more source

Suppressive CD8+ T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis

Journal of Clinical Apheresis, Volume 41, Issue 1, February 2026.
ABSTRACT Extracorporeal photopheresis (ECP) is a widely utilized immunomodulatory procedure with an incompletely defined mechanism. In graft‐versus‐host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T‐cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell–mediated ...
Kai J. Rogers, Kathryn L. Eschbacher, Zeb Zacharias, Kshitija Kale, Michael P. Crawford, Charles Michael Knudson, Alexander W. Boyden, Nitin J. Karandikar   +7 more
wiley   +1 more source

Investigation of the Regulatory Mechanism of Huazhuo Runzao Jiangqi Formula on Esophageal Cancer Utilizing Network Pharmacology, Molecular Docking, and In Vivo and In Vitro Experiments

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Esophageal cancer, a common digestive malignant neoplasm globally, poses significant health risks. Huazhuo Runzao Jiangqi (HRJ) formula, modified from the classic “Qige Powder” with additions and reductions, has shown clear efficacy in treating esophageal cancer and precancerous lesions in clinical practice and preliminary studies ...
Yun He, Huan-Fang Fan, De-Hui Li, Zi-Hui Liu, Yi-Ting Gu, Chang-Hui Han, Pan Ma, Na Guo, Xiao Wang, Yan Han, Irfan Ahmad   +10 more
wiley   +1 more source

Exposure Registries as a Prevention Tool for Occupational Cancers: Establishing a New Hazardous Drug Registry for Oncology Personnel

American Journal of Industrial Medicine, Volume 68, Issue 12, Page 1037-1047, December 2025.
ABSTRACT Public health registries collect and maintain demographic and health data on a cohort of people with a common disease or exposure. While disease registries have proliferated in recent decades, registries comprising persons with potentially hazardous exposures—known commonly as exposure registries—are rare.
Sammy Almashat, Matthew Horch, Brian Chen, Melissa McDiarmid   +3 more
wiley   +1 more source

8-methoxsalen photochemistry enhances tumor cell immunogenicity by inducing ferroptosis in B16 cells

Zhongguo shuxue zazhi
[Objective] To study the efficacy of photosensitizer 8- methoxsalen (8-MOP) combined with ultraviolet radiation A (UVA) in inducing ferroptosis in mouse melanoma B16 cells, and to assess the resultant changes in immunogenicity, and their impact on ...
ZHONG Yan, LIN Yuwei, CHEN Wei, TIAN Li, LI Ling, LIU Zhong   +5 more
doaj   +1 more source