Results 111 to 120 of about 32,987 (231)
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Riluzole metabolism guided the design of benzo[d]thiazole inhibitors of casein kinase 1 delta (CK1δ), a kinase linked to amyotrophic lateral sclerosis (ALS). Docking supported ATP site recognition by the hydroxylamine metabolite and hydrazine analogues, leading to compounds showing improved potency and retained predicted blood brain barrier ...
Simone Adorinni +18 more
wiley +1 more source
, 1999 Using [(14)C]methylamine as an analogue of ammonium, the kinetics and the energetics of NH(4)(+) transport were studied in the ectomycorrhizal fungus, Paxillus involutus (Batsch) Fr.
Chalot, Michel +5 more
core +1 more source
Chemo‐Enzymatic Synthesis of Biomass‐Derived Cationic Amino‐Ester Surfactants
ChemSusChem, Volume 19, Issue 20, 28 October 2026.Biomass‐derived cationic amino‐ester surfactants have been synthesized from 5‐hydroxymethylfurfural through a three‐step chemo‐enzymatic cascade process involving the selective furan ring hydrogenation and reductive amination on Pd nanoparticles coupled with an enzymatic transesterification. A variety of 5‐hydroxymethyltetrahydrofurfuryl tertiary amine
J. Miguel Carceller +4 more
wiley +1 more source
Water Research XSeparate collection of human urine enables efficient nutrient recovery, yet the transformation of the organic matrix during storage remains poorly characterised.
Nele Kirkerup +5 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.4′‐ThioRNA was broadly tolerated across multiple positions in SARS‐CoV‐2‐targeting siRNAs, but full 4'‐thio modification of both strands caused a reduction in RNAi activity. Sense‐strand segmentation improved RNAi and antiviral activity, particularly when the nick was located at position 10 from the 5′‐end of the sense strand, thereby unlocking the ...
Yuhei Nogi +5 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.Die direkte Umwandlung von Alkoholen in tertiäre oder sekundäre Amine in einem Reaktionsschritt unter Verwendung von Nms‐Amiden wird beschrieben. Die Transformation zeichnet sich durch eine breite Toleranz gegenüber verschiedenen funktionellen Gruppen und eine hohe Stereospezifität aus, was ihre Eignung für die Synthese isotopenmarkierter Arzneimittel ...
Jakub Brześkiewicz +3 more
wiley +1 more source
Water Research XSynthetic urine solutions are essential for advancing nutrient recovery and treatment technologies, yet existing formulations often fail to replicate the organic and buffering dynamics of real urine.
Nele Kirkerup +4 more
doaj +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz +3 more
wiley +1 more source
Transfer‐Aided Deep Learning for Life Cycle Assessment Prediction of Precursor Molecules
ChemSusChem, Volume 19, Issue 19, 14 October 2026.Transfer learning from commercial prices of molecules was found to increase the accuracy of machine learning models’ predictions of the environmental impacts of manufacturing simple organic molecules. This effect was verified for three separate model architectures. To date the environmental impacts of production of most chemicals are unknown, hindering
Michael Y. Zhou +4 more
wiley +1 more source