Results 91 to 100 of about 1,069,555 (390)

Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma

Frontiers in Oncology
PurposeThe aim of this study is to investigate whether the therapeutic efficacy of bevacizumab (BEV) in the treatment of high-grade glioma (HGG) is associated with the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) on the basis of ...
Chengrui Yan, Xuexue Bai, Chao Wu, Wenbin Ma, Ming Feng   +4 more
doaj   +1 more source

Early-Onset Schizophrenia: A Special Phenotype of the Disease Characterized by Increased MTHFR Polymorphisms and Aggravating Symptoms

Neuropsychiatric Disease and Treatment, 2021
Lin Wan, Jing Wei Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Jing WeiDepartment of Psychological ...
Wan L, Wei J
doaj  

Differentially methylated CpG sites associated with the high-risk group of prostate cancer

Journal of Integrative Bioinformatics, 2020
Prostate cancer (PC) is one of the most common and socially significant oncological diseases among men. Bioinformatic analysis of omics data allows identifying molecular genetic changes associated with the disease development, as well as markers of ...
Kobelyatskaya Anastasiya, Pudova Elena, Fedorova Maria, Nyushko Kirill, Alekseev Boris, Kaprin Andrey, Trofimov Dmitry, Sukhikh Gennady, Snezhkina Anastasia, Krasnov George, Razin Sergey, Kudryavtseva Anna   +11 more
doaj   +1 more source

The Studies of Prognostic Factors and the Genetic Polymorphism of Methylenetetrahydrofolate Reductase C667T in Thymic Epithelial Tumors

Frontiers in Oncology, 2022
ObjectiveTo describe the clinical features of a cohort of patients with thymic epithelial tumors (TETs) and to analyze their prognostic factors. In particular, we investigated the correlation between the genetic polymorphism of methylenetetrahydrofolate ...
Miaolong Yan, Miaolong Yan, Jiayuan Wu, Min Xue, Min Xue, Juanfen Mo, Li Zheng, Jun Zhang, Zhenzhen Gao, Yi Bao, Yi Bao   +10 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Detection of WNT7A Methylation in Peripheral Blood of NSCLC Patients and Its Diagnostic Value

Zhongliu Fangzhi Yanjiu, 2019
Objective To explore the relation between WNT7A methylation and clinical factors of NSCLC patients. Methods We selected 120 NSCLC patients as NSCLC group and 120 healthy people as control group.
XU Yao, ZHANG Chang, PENG Li, ZHANG Junxia   +3 more
doaj   +1 more source

CpG Island Methylation of Suppressor of Cytokine Signaling-1 Gene Induced by HCV Is Associated With HCV-Related Hepatocellular Carcinoma

Frontiers in Microbiology, 2022
Suppressor of cytokine signaling 1 (SOCS-1) is implicated in both virus infection and carcinogenesis. This study investigated the role of HCV infection on SOCS-1 in normal and HCV-infected tissues and revealed a possible mechanism underlying HCV-induced ...
Miao Liu, Lingyao Du, Xing Cheng, Man Yuan, Jin Shang, Jin Shang, Ying Shi, Hailing Yang, Hailing Yang, Hong Tang   +9 more
doaj   +1 more source

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

Genome Biology, 2012
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene regulation,cellular specification and cancer development. Here, we describe an R package, methylKit, thatrapidly analyzes genome-wide cytosine epigenetic profiles from ...
A. Akalin, Matthias Kormaksson, Sheng Li, Francine E. Garrett-Bakelman, M. Figueroa, A. Melnick, C. Mason   +6 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface [PDF]

, 2009
Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.
Albertson, Anderson, Arai, Avila, Barrera, Barrera, Bock, Bodnar, Boris Novakovic, Carter, Chaddha, Chiu, Chung, Coan, d'Alesio, Danielle Evain-Brion, Davis, Deeb, DeLuca, Delvin, Delvin, Diaz, Dimitriadis, Dodds, Du, Dusso, Eva Dimitriadis, Evans, Evans, Fischer, Friso, Holick, Hong Kiat Ng, Jeffrey M. Craig, Jennings, Kim, Kohler, Kovacs, Kumar, Lauridsen, Leader, Lechner, Li, Liu, Lohnes, Lopez, Lopez, Makin, Malloy, Mandy Sibson, Masuda, Muller, Murayama, Nelen, Nelen, Nelen, Novakovic, Ohyama, Pattillo, Pattillo, Paulson, Pavan, Peehl, Pendas-Franco, Pospechova, Rahnama, Rakyan, Richard Saffery, Ron, Ross, Ross, Ruth Morley, Salle, Seely, Serman, Shih Ie, Sikora, Siu-Caldera, Soundararajan, Stephan Beck, Stephanou, Sung, Tapia, Tashiro, Taylor, Thierry Fournier, Thomas Down, Tsang, Ursula Manuelpillai, Valdivielso, van der Molen, Vardhman Rakyan, Vigano, von Rango, Whitfield, Wietrzyk, Wong, Wong, Xie, Zehnder, Zhang, Zhou   +101 more
core   +3 more sources