Results 91 to 100 of about 779,387 (379)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Saudi Journal of Medicine and Medical Sciences, 2020 Background: Spleen tyrosine kinase (SYK) is an important enzyme in the proliferation and differentiation of all hematopoietic tissues. Its role as a cancer driver is well documented in liquid tumors; however, cumulative evidence has suggested an opposite
Akram I Alwithenani +1 more
doaj +1 more source
An interplay between BRD4 and G9a regulates skeletal myogenesis
Frontiers in Cell and Developmental Biology, 2022 Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression.
Naidi Yang +8 more
doaj +1 more source
Constraints of the formation and abundances of methyl carbamate, a glycine isomer, in hot corinos [PDF]
, 2020 Methyl carbamate CH$_3$OC(O)NH$_2$ is an isomer of glycine. Quantum chemical analyses show that methyl carbamate is more stable isomer than glycine. Because of this, there could be a higher chance for methyl carbamte to exist in the interstellar medium as compared to glycine.
arxiv +1 more source
DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]
, 2018 Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario +9 more
core +2 more sources
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Frontiers in Genetics, 2020 Objectives: The occurrence of hepatocellular carcinoma (HCC) is a complex process involving genetic mutations, epigenetic variation, and abnormal gene expression.
Ziyu Liu +6 more
doaj +1 more source
Frontiers in Oncology, 2022 DNA methylation is the most recognized epigenetic mark that leads to a massive distortion in cancer cells. It has been observed that a large number of DNA aberrant methylation events occur simultaneously in a group of genes, thus providing a growth ...
Federico Pio Fabrizio +15 more
doaj +1 more source
DNA methylation and socioeconomic status in a Mexican-American birth cohort. [PDF]
, 2018 Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships.
Coker, Eric +4 more
core +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source