Results 91 to 100 of about 1,050,423 (388)
Shedding light upon the complex net of genome size, genome composition and environment in chordates
The European Zoological Journal, 2020 The nucleotype theory has been advanced on the basis of studies regarding genome size and composition in various plant and animal species, i.e. the influence that genome can have on the phenotype independently of the informational content of DNA.
A. Canapa +5 more
doaj +1 more source
Frontiers in Immunology, 2021 DNA methylation patterns are essential in understanding carcinogenesis. However, the relationship between DNA methylation and the immune process has not been clearly established—this study aimed at elucidating the interaction between glioma and DNA ...
Zhengang Hu +13 more
doaj +1 more source
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]
, 2019 Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep +4 more
core +1 more source
Nature Communications, 2018 Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent cell death events in the body. Here, we present an approach for unbiased determination of the tissue origins of cfDNA, using a reference methylation atlas of ...
J. Moss +22 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis [PDF]
, 2011 Background\ud DNA methylation is an epigenetic mechanism associated with regulation of gene expression and it is modulated during chemical carcinogenesis.
Chipman, J Kevin +4 more
core +4 more sources
The role of m6A RNA methylation in human cancer
Molecular Cancer, 2019 N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs).
Xiaoyu Chen, Jing Zhang, Jinshui Zhu
semanticscholar +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme
G3: Genes, Genomes, Genetics, 2018 Glioblastoma multiforme (GBM) has been recognized as the most lethal type of malignant brain tumor. Despite efforts of the medical and research community, patients’ survival remains extremely low.
Yeni L. Bernal Rubio +8 more
doaj +1 more source
A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells
eLife, 2021 A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of ...
Xue Chen +14 more
doaj +1 more source