Results 91 to 100 of about 881,260 (340)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Methylation of the RASSF1A, RARβ2, and SEMA3B genes in epithelial breast and ovarian tumors, and in patients with polyneoplasia

Опухоли женской репродуктивной системы, 2014
The methylation status of the tumor suppressor genes RASSF1A, RARβ2, and SEMA3B was studied in the samples of cancer and its histologically normal tissue of the breast and ovaries.
T. P. Kazubskaya, V. I. Loginov, D. S. Khodyrev, V. D. Ermilova, Yu. G. Payanidi, N. V. Chkhikvadze, V. Yu. Selchuk, E. A. Braga   +7 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

From early stress to 12-month development in very preterm infants: Preliminary findings on epigenetic mechanisms and brain growth [PDF]

, 2018
Very preterm (VPT) infants admitted to Neonatal Intensive Care Unit (NICU) are at risk for altered brain growth and less-than-optimal socio-emotional development.
Borgatti, R., C., Squarcina, Carli, De, F., Brambilla, F., Sirgiovanni, Fumagalli, M., I., Giorda, L., Pozzoli, Montirosso, Rosario, Mosca, F., P., Dessimone, Provenzi, L., R., Cinnante, U., Triulzi   +13 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface [PDF]

, 2009
Plasma concentrations of biologically active vitamin D (1,25- (OH)2D) are tightly controlled via feedback regulation of renal 1-hydroxylase (CYP27B1; positive) and 24-hydroxylase (CYP24A1; catabolic) enzymes.
Albertson, Anderson, Arai, Avila, Barrera, Barrera, Bock, Bodnar, Boris Novakovic, Carter, Chaddha, Chiu, Chung, Coan, d'Alesio, Danielle Evain-Brion, Davis, Deeb, DeLuca, Delvin, Delvin, Diaz, Dimitriadis, Dodds, Du, Dusso, Eva Dimitriadis, Evans, Evans, Fischer, Friso, Holick, Hong Kiat Ng, Jeffrey M. Craig, Jennings, Kim, Kohler, Kovacs, Kumar, Lauridsen, Leader, Lechner, Li, Liu, Lohnes, Lopez, Lopez, Makin, Malloy, Mandy Sibson, Masuda, Muller, Murayama, Nelen, Nelen, Nelen, Novakovic, Ohyama, Pattillo, Pattillo, Paulson, Pavan, Peehl, Pendas-Franco, Pospechova, Rahnama, Rakyan, Richard Saffery, Ron, Ross, Ross, Ruth Morley, Salle, Seely, Serman, Shih Ie, Sikora, Siu-Caldera, Soundararajan, Stephan Beck, Stephanou, Sung, Tapia, Tashiro, Taylor, Thierry Fournier, Thomas Down, Tsang, Ursula Manuelpillai, Valdivielso, van der Molen, Vardhman Rakyan, Vigano, von Rango, Whitfield, Wietrzyk, Wong, Wong, Xie, Zehnder, Zhang, Zhou   +101 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]

, 2015
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C, Ashworth, A, Baglietto, L, Chadeau, M, Curry, E, Flanagan, JM, Flower, K, Frasca, G, Garcia-Closas, M, Jones, M, Krogh, V, Lund, E, Masala, G, Mattiello, A, Orr, N, Palli, D, Panico, S, Polidoro, S, Sacerdote, C, Sandanger, T, Severi, G, Swerdlow, A, Tomczyk, K, Tumino, R, van veldhoven, K, vineis, P   +25 more
core   +5 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation [PDF]

, 2020
Zhong Zheng, Linda Zhang, Xiaolong Cui, Xianbin Yu, Phillip J. Hsu, Ruitu Lyu, Haiyan Tan, Malay Mandal, Michelle Zhang, Hui‐Lung Sun, Arantxa Sanchez Castillo, Junmin Peng, Marcus R. Clark, Chuan He, Haochu Huang   +14 more
openalex   +1 more source