Results 111 to 120 of about 1,069,555 (390)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

DNA Methylation in Acacia mangium ln vitro and Ex-vitro buds, in relation to their within-shoot position, age and leaf morphology of the shoots [PDF]

, 2009
DNA methylation was analyzed in Acacia mangium Willd. buds collected from in vitro and field growing shoots from the same clone and its juvenile offspring.
Baurens, Franc-Christophe, Doulbeau, Sylvie, Goh, Doreen Kim Soh, Monteuuis, Olivier, Quimado, M., Verdeil, Jean-Luc   +5 more
core   +1 more source

Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring [PDF]

, 2022
Yunyun Liu, Shengzhu Chen, Dejian Pang, Jiayi Zhou, Xiuting Xu, Si Yang, Zhaofeng Huang, Bolan Yu   +7 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis [PDF]

, 2015
Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is ...
Agnoli, C, Ashworth, A, Baglietto, L, Chadeau, M, Curry, E, Flanagan, JM, Flower, K, Frasca, G, Garcia-Closas, M, Jones, M, Krogh, V, Lund, E, Masala, G, Mattiello, A, Orr, N, Palli, D, Panico, S, Polidoro, S, Sacerdote, C, Sandanger, T, Severi, G, Swerdlow, A, Tomczyk, K, Tumino, R, van veldhoven, K, vineis, P   +25 more
core   +5 more sources

The Relevance of SOCS1 Methylation and Epigenetic Therapy in Diverse Cell Populations of Hepatocellular Carcinoma [PDF]

, 2021
Loraine Kay D. Cabral, Peter Andrew C. Reyes, Lory Saveria Crocè, Claudio Tiribelli, Caecilia Sukowati   +4 more
openalex   +1 more source

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Nature Communications, 2019
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial ...
H. Jung, H. Kim, Jeong Yeon Kim, Jong-Mu Sun, J. Ahn, M. Ahn, Keunchil Park, M. Esteller, Se-Hoon Lee, J. Choi   +9 more
semanticscholar   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells

International Journal of Nanomedicine, 2020
Tianke Zhang,1,2 E Du,1 Yan Liu,1 Jun Cheng,2 Zhihong Zhang,1 Yong Xu,1 Shiyong Qi,1 Yue Chen1 1Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, People’s Republic of China ...
Zhang T, Du E, Liu Y, Cheng J, Zhang Z, Xu Y, Qi S, Chen Y   +7 more
doaj  

Deciphering the Methylation Landscape in Breast Cancer: Diagnostic and Prognostic Biosignatures through Automated Machine Learning [PDF]

, 2021
Μαρία Παναγοπούλου, Makrina Karaglani, Vangelis G. Manolopoulos, Ioannis Iliopoulos, Ioannis Tsamardinos, Εkaterini Chatzaki   +5 more
openalex   +1 more source