Results 111 to 120 of about 881,260 (340)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Promoter methylation and increased expression of PD-L1 in patients with active tuberculosis

Microbial Cell
The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of Mycobacterium tuberculosis (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in cancer cells. However, its effect on PD-
Yen-Han Tseng, Sheng-Wei Pan, Jhong-Ru Huang, Chang-Ching Lee, Jung-Jyh Hung, Po-Kuei Hsu, Nien-Jung Chen, Wei-Juin Su, Yuh-Min Chen, Jia-Yih Feng   +9 more
doaj   +1 more source

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation. [PDF]

, 2018
AimTo examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.Materials & methodsIn a diverse, prospective community sample of 178 kindergarten ...
Adler, Nancy E, Boyce, W Thomas, Bush, Nicole R, Edgar, Rachel D, Essex, Marilyn J, Kobor, Michael S, MacIsaac, Julia L, McEwen, Lisa M, Park, Mina   +8 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Implications of petrochemical exposure and epigenetic alterations on human health

Frontiers in Toxicology
The petrochemical industry and automobiles contribute significantly to hazardous waste, which contains a broad array of organic and inorganic compounds posing serious health risks.
Selvaraj Jayaraman, Anupriya Eswaran, Vishnu Priya Veeraraghavan, Mohammed Fazal, Adham Al-Rahbi, Srinivasa Rao Sirasanagandla   +5 more
doaj   +1 more source

Dynamics of epigenetic remodeling in interspecies porcine zygotes

Czech Journal of Animal Science, 2012
The process of active paternal chromatin demethylation after fertilization in the pig is not fully understood and very inconsistent data have been published by different research groups.
I. Barnetova, I. Vackova, P. Firla
doaj   +1 more source

Lysine Methylation Regulates E2F1-Induced Cell Death [PDF]

, 2010
Haroula Kontaki, Iannis Talianidis
openalex   +1 more source

Combined Effects of ESRα DNA Methylation and Progesterone on Glucose Metabolic Disorders: The Henan Rural Cohort Study [PDF]

, 2023
Bo Feng, Lulu Wang, Dandan Wei, Wenqian Huo, Tao Jing, Chongjian Wang, Zhenxing Mao   +6 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth

Epigenetics
Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of maternal ACEs, and their interaction with financial stress and ...
Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, William Schlief, Cathrine Hoyo   +8 more
doaj   +1 more source