Results 181 to 190 of about 881,260 (340)

The role of DNA methylation in the pathogenesis of type 2 diabetes mellitus [PDF]

, 2020
Sanabil Ali Hassan Ahmed, Suraiya Anjum Ansari, E.P.K. Mensah‐Brown, Bright Starling Emerald   +3 more
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Methylation of Deoxyribonucleic Acid in Regenerating Rat Liver [PDF]

, 1973
D. Lutz, H. Grahn, Hans Kröger
openalex   +1 more source

Epigenome-wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study

, 2021
Thanh T. Hoang
openalex   +2 more sources

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

DNA methylation analysis: a promising diagnostic tool / DNA-Methylierungs-Analyse: ein vielversprechendes diagnostisches Werkzeug [PDF]

, 2004
Matthias Schuster
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Linking the Epigenome to the Genome: Correlation of Different Features to DNA Methylation of CpG Islands

, 2012
Clemens Wrzodek, Finja Büchel, Georg Hinselmann, Johannes Eichner, Florian Mittag, Andreas Zell   +5 more
openalex   +2 more sources

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Genome-wide methylation detection and episignature analysis using PacBio long-read sequencing. [PDF]

Genome Med
Ivashchenko V, de Groot M, Derks R, den Ouden A, Khazeeva G, van den Heuvel S, Timmermans R, Corominas Galbany J, Pfundt R, Hofste T, Yntema H, Vissers L, Hoischen A, Hampstead J, Gilissen C.   +14 more
europepmc   +1 more source