Results 201 to 210 of about 652,669 (356)

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

A nomogram for predicting 3-year total weight loss percentage following LSG: insights from visceral adipose tissue inflammatory methylation sites. [PDF]

BMC Surg
Li Z, Wang L, Wang Z, Wuyun Q, Amin B, Lian D, Xu G, Zhang N, Wang D.   +8 more
europepmc   +1 more source

Chemical Studies of Histone Methylation

, 1969
Edward L. Gershey, G. W. HASLETT, G. Vidali, V. G. Allfrey   +3 more
openalex   +1 more source

The Methylation of 3-Picoline and N-(3-Picolyl)-pyrrolidine with Methyl-lithium. [PDF]

, 1967
F. Haglid, Jan Olof Noren, Gunilla Isaksson, Jan Sandström, Hugo Theorell, R. Blinc, S. Paušak, L. Ehrenberg, J. Dumanović   +8 more
openalex   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

Longitudinal transcriptomic and epigenetic analysis of the blood in two astronauts. [PDF]

Sci Rep
Ao X, Parisien M, Cata JP, Montagna F, Vigouroux M, Oliveira Fernandes de Araujo L, Karaky M, Ingelmo P, Diatchenko L.   +8 more
europepmc   +1 more source

The Methylation of Lysine Residues in Protein

, 1966
Donald G. Comb, Nilima Sarkar, Charles J. Pinzino   +2 more
openalex   +1 more source

MYC/TET3‐Regulated TMEM65 Activates OXPHOS‐SERPINB3 Pathway to Promote Progression and Cisplatin Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) remains a major challenge in breast cancer management as it lacks effective therapeutic targets. This study uncovers that MYC/TET3‐regulated mitochondrial inner‐membrane protein TMEM65 promotes TNBC progression and cisplatin resistance by activating the OXPHOS‐SERPINB3 pathway and reveals TMEM65 as a potential ...
Yin‐Ling Zhang, Min‐Ying Huang, Shao‐Ying Yang, Jia‐Yang Cai, Qian Zhao, Fang‐Lin Zhang, Xin Hu, Zhi‐Min Shao, Li Liao, A‐Yong Cao, Da‐Qiang Li   +10 more
wiley   +1 more source

LINE-1 Methylation sustains telomere length in pregnant women: effects on pregnancy failure. [PDF]

Clin Epigenetics
Gemmati D, Scarpellini F, Salvatori F, D'Aversa E, Marci R, Capucci R, Antonica B, Grisafi M, Turato E, Vargas JV, Secchiero P, Zauli G, Singh AV, Tisato V.   +13 more
europepmc   +1 more source

The Enzymatic Methylation of Ribonucleic Acid and Deoxyribonucleic Acid

, 1965
Jerard Hurwitz, Monika Anders, Marvin Gold, Issar Smith   +3 more
openalex   +1 more source