Results 201 to 210 of about 1,069,555 (390)

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Cell, 1999
M. Okano, D. Bell, D. Haber, E. Li
semanticscholar   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer [PDF]

, 2017
Vassiliki Saloura, Theodore Vougiouklakis, Makda Zewde, Xiaolan Deng, Kazuma Kiyotani, Jae‐Hyun Park, Yo Matsuo, Mark W. Lingen, Takehiro Suzuki, Naoshi Dohmae, Ryuji Hamamoto, Yusuke Nakamura   +11 more
openalex   +1 more source

Isocitrate dehydrogenase wt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2’O-methylation of ribosomal RNA [PDF]

, 2023
Hermes Paraqindes, Nour‐El‐Houda Mourksi, Samantha Ballesta, Jordan Hedjam, Fleur Bourdelais, Tanguy Fenouil, Thiébaud Picart, Frédéric Catez, Théo Combe, Anthony Ferrari, Janice Kielbassa, Emilie Thomas, Laurie Tonon, Alain Viari, Valéry Attignon, Marjorie Carrère, Jessie Perrossier, Stéphane Giraud, Christophe Vanbelle, Mathieu Gabut, Danny Bergeron, Michelle S Scott, Luis Castro Vega, Nathalie Magne, Emmanuelle Huillard, Marc Sanson, David Meyronet, Jean‐Jacques Diaz, François Ducray, Virginie Marcel, Sébastien Durand   +30 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

An endogene-resembling transgene is resistant to DNA methylation and systemic silencing [PDF]

, 2014
Elena Dadami, Athanasios Dalakouras, Michèle Zwiebel, Gabi Krczal, Michael Wassenegger   +4 more
openalex   +1 more source

Conditional GWAS of non-CG transposon methylation in Arabidopsis thaliana reveals major polymorphisms in five genes

, 2022
Eriko Sasaki, Joanna Gunis, Ilka Reichardt, Viktoria Nizhynska, Magnus Nordborg   +4 more
openalex   +1 more source

DNA Methylation and Its Basic Function

Neuropsychopharmacology, 2013
Lisa D. Moore, Thuc M. Le, G. Fan
semanticscholar   +1 more source

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Early Detection of Fragile X Syndrome: Applications of a Novel Approach for Improved Quantitative Methylation Analysis in Venous Blood and Newborn Blood Spots [PDF]

, 2014
Yoshimi Inaba, Charles E. Schwartz, Minh Bui, Xin Li, Cindy Skinner, Michael Field, Tiffany Wotton, Randi J. Hagerman, David Francis, David J. Amor, John L. Hopper, Danuta Z. Loesch, Lesley Bretherton, Howard R. Slater, David E. Godler   +14 more
openalex   +1 more source