Results 221 to 230 of about 881,260 (340)

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Gene-body DNA methylation of ONECUT2 predicts its expression and prostate cancer aggressiveness in needle biopsies. [PDF]

Biomark Res
Sekino Y, Li HT, Kaneko M, Inoue Y, Ramacciotti LS, Lu R, Deng Z, Zhou X, Song MM, Desai A, Jin M, Guo W, Yang X, Bhasin J, Hinata N, Freeman MR, Gill I, Aron M, Cen SY, Abreu AL, Liang G.   +20 more
europepmc   +1 more source

Additional file 12: of Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana

, 2015
Yizhen Wan, Kai Tang, Da‐Yong Zhang, Shaojun Xie, Xiaohong Zhu, Zegang Wang, Zhaobo Lang   +6 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

DNA Methylation Fine-Tunes Light- and Hormone-Responsive Growth Plasticity in <i>Arabidopsis</i> Seedlings. [PDF]

Int J Mol Sci
Talarico E, Greco E, Chiappetta A, Araniti F, Bruno L.   +4 more
europepmc   +1 more source

N6-Methyladenosine Methylation of mRNA in Cell Senescence

, 2021
Lin Zhang, Jian Xia
openalex   +2 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

First Indonesian Nasopharyngeal Cancer Whole Epigenome Sequencing Identify Tumour Suppressor CpG Methylation

Biologics: Targets & Therapy
Handoko,1– 3 Marlinda Adham,2,4 Lisnawati Rachmadi,2,5 Demak Lumban Tobing,6 Asmarinah,7 Fadilah,8 Wei Dai,9,10 Anne Wing Mui Lee,10 Soehartati A Gondhowiardjo2,3 1Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia ...
Handoko, Adham M, Rachmadi L, Tobing DL, Asmarinah A, Fadilah F, Dai W, Lee AWM, Gondhowiardjo SA   +8 more
doaj  

Trans-Tissue Effects of Hippocampus- and Blood-Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis. [PDF]

Bipolar Disord
Ohi K, Fujikane D, Takai K, Kuramitsu A, Muto Y, Sugiyama S, Shioiri T.   +6 more
europepmc   +1 more source

RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis [PDF]

, 2007
Inga Peters, Kristina Rehmet, Nadine Wilke, Markus A. Kuczyk, Jörg Hennenlotter, Tyark Eilers, S. Machtens, Udo Jonas, Jürgen Serth   +8 more
openalex   +1 more source