Results 221 to 230 of about 1,050,423 (388)

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

open access: yesAdvanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li   +4 more
wiley   +1 more source

Spatiotemporal methylome remodeling during fiber differentiation in Gossypium hirsutum. [PDF]

open access: yesBMC Genomics
Yu Z   +7 more
europepmc   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

open access: yesAdvanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang   +6 more
wiley   +1 more source

DNA methylation and machine learning: challenges and perspective toward enhanced clinical diagnostics. [PDF]

open access: yesClin Epigenetics
Aref-Eshghi E   +11 more
europepmc   +1 more source

Chemical Studies of Histone Methylation

open access: hybrid, 1969
Edward L. Gershey   +3 more
openalex   +1 more source

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