Results 241 to 250 of about 1,069,555 (390)

METTL1‐Mediated M7G tRNA Modification Promotes Residual Liver Regeneration After Hepatectomy via Translational Control

Advanced Science, EarlyView.
METTL1 and its mediated m7G tRNA modification are significantly up‐regulated after partial hepatectomy (PHx). Overexpression of METTL1 improves the efficiency of liver regeneration after PHx, increases the proliferation of hepatocytes, and accelerates the recovery of liver function.
Manling Huang, Shuirong Lin, Yutong Zhao, Jiale Chen, Linyuan Huang, Yuyao Liu, Zixin Huang, Dongxin An, Yifan Zhang, Zimin Song, Xi Yu, Yunpeng Hua, Jing Wang, Weiwei Wang, Yu Guo, Ming Kuang, Fang Wang, Shuibin Lin, Shunli Shen   +18 more
wiley   +1 more source

Research progress on m6A RNA methylation modification in human reproduction related diseases. [PDF]

Eur J Med Res
Sui X, Liu Y, Wang Z, Sui Y, Gao L.
europepmc   +1 more source

Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation [PDF]

, 2020
Jusik Kim, Keeeun Kim, Jung‐Soon Mo, Youngsoo Lee   +3 more
openalex   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Reconfiguration of DNA methylation at growth resumption after winter dormancy in Kiwifruit. [PDF]

Sci Rep
Wu R, Chen TH, Voogd C, Allan AC, Varkonyi-Gasic E.   +4 more
europepmc   +1 more source

Pre-Operative Evaluation of DNA Methylation Profile in Oral Squamous Cell Carcinoma Can Predict Tumor Aggressive Potential [PDF]

, 2020
Davide Bartolomeo Gissi, Viscardo Paolo Fabbri, Andrea Gabusi, Jacopo Lenzi, Luca Morandi, Sofia Melotti, Sofia Asioli, Achille Tarsitano, Tiziana Balbi, Claudio Marchetti, Lucio Montebugnoli   +10 more
openalex   +1 more source

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

The Association of Lipoic Acid Synthase (<i>LIAS</i>) Gene Methylation With Diabetic Kidney Disease. [PDF]

J Diabetes Res
Feng Z, Liu T, Gao P, Jiang Y, Zhao M, Liu Y, Zhu H, Li M, Li N, Kong X, Ma L.   +10 more
europepmc   +1 more source

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Nature, 2008
A. Meissner, T. Mikkelsen, H. Gu, Marius Wernig, J. Hanna, A. Sivachenko, Xiaolan Zhang, B. Bernstein, C. Nusbaum, D. Jaffe, A. Gnirke, R. Jaenisch, E. Lander   +12 more
semanticscholar   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source