Results 241 to 250 of about 652,669 (356)

Epigenetic Mechanisms in <i>Apis melifera</i>: From Development to Environmental Adaptation. [PDF]

Curr Issues Mol Biol
Hu X, Xu J, Wang K.
europepmc   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

Hypermethylation and increased expression of the DRD2 gene in schizophrenia. [PDF]

BMC Psychiatry
Qing L, Zou T, Yin W, Wu R, Cheng T, Yuan H, Zhou C, Chen X, Wang J, Yang T, Hu L, Liu L, Nie S.   +12 more
europepmc   +1 more source

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Differentiation of mtDNA Methylation in Tissues of Ridgetail White Prawn, <i>Exopalaemon carinicauda</i>. [PDF]

Animals (Basel)
Jiang M, Gao J, Zhou X, Zhong H, Zhang S, Xu J, Yu F, Lai X, Yan B, Gao H.   +9 more
europepmc   +1 more source

Inhibition of the methylation of histamine in cat brain

, 1961
Tonya White
openalex   +2 more sources

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

DNA methylation profiling for molecular classification of neuroblastoma. [PDF]

Clin Epigenetics
Löfgren M, Djos A, Rezaei S, Suman M, Kogner P, Martinsson T, Fransson S, Carén H.   +7 more
europepmc   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source

Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma. [PDF]

Clin Epigenetics
Colin-Leitzinger C, Lawson-Michod KA, Johnson CE, Vlasac IM, Yoder S, Mesa T, Roeber D, Huff C, Hildebrandt MAT, Haller K, Alberg AJ, Bandera EV, Bondy M, Cote ML, Hastert T, Peters ES, Terry PD, Lawson AB, Berchuck A, Fridley BL, Chern JY, Doherty JA, Marks JR, Schildkraut JM, Christensen BC, Salas LA, Peres LC.   +26 more
europepmc   +1 more source