Results 241 to 250 of about 443,290 (339)

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Histone modifications in the regulation of erythropoiesis. [PDF]

Ann Med
Wu X, Xu H, Xia E, Gao L, Hou Y, Sun L, Zhang H, Cheng Y.   +7 more
europepmc   +1 more source

Formic Acid Reduction. III. Barbituric Acid Derivatives. New 5-Methylation Reaction of Barbituric Acid Derivatives with Formate and Course of the Reaction

, 1969
Minoru Sekiya, Chizuko Yanaihara
openalex   +2 more sources

Clonal Hematopoiesis and Thrombosis

American Journal of Hematology, EarlyView.
ABSTRACT Clonal hematopoiesis (CH) has been the focus of many research efforts in the last years and has emerged as a risk modifier for cardiovascular disease morbidity and mortality. While substantial evidence has accumulated regarding its impact on arterial system diseases, the connection with venous thrombosis has only recently been explored.
Cornelia Englisch, Cihan Ay
wiley   +1 more source

Enhancing the precision of auxiliary diagnosis for lung cancer through use of <i>SHOX2</i> and <i>RASSF1A</i> methylation status in lung biopsy and lymph node biopsy specimens. [PDF]

Transl Lung Cancer Res
Gu P, Wang Y, Shi C, Chen Y, Qian J, Niu Y, Zhang H, Bao Y, She B, Ren X, Izevbaye I, Han B, Zhong H, Dong Y.   +13 more
europepmc   +1 more source

Enzymatic Methylation of Homocysteine by a Synthetic Tetrahydrofolate Derivative

, 1961
Warwick Sakami, I Ukstins
openalex   +1 more source

Epigenetics of maternal-fetal interface immune microenvironment and placental related pregnancy complications. [PDF]

Front Immunol
Ma X, Chen X, Mu X, Cao M, Zhang Y.
europepmc   +1 more source

Abnormal DNA Methylation Profile Suggests the Extension of the Clinical Spectrum of the SETD2‐Related Disorders to a Syndromic Multiple Tumor Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SETD2 has an essential role in epigenetic regulation. SETD2 pathogenic variants cause neurodevelopmental disorders (SETD2‐NDDs) that most commonly include various degrees of intellectual disability and behavioral disorders, macrocephaly, brain malformations, and generalized overgrowth.
Marie Lucain, Antonio Vitobello, Bekim Sadikovic, Juliette Albuisson, Léa Gaudillat, Martin Chevarin, Julien Maraval, Christel Thauvin‐Robinet, Jennifer Kerkhof, Christophe Philippe, Sophie Nambot, Laurence Faivre   +11 more
wiley   +1 more source

A New EP300‐Related Syndrome With Prominent Developmental and Immune Phenotypes

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Rubinstein Taybi syndrome (RTS) is a disorder of chromatin remodeling and transcriptional regulation caused by heterozygous pathogenic variants in CREBBP and EP300. RTS is characterized by a distinct facial gestalt, intellectual disability, structural kidney and heart differences, feeding difficulties, and broad thumbs and great toes ...
Devi Priyanka Maripuri, Jessica Gold, Nina Gold, Alanna Strong   +3 more
wiley   +1 more source

The association between blood-based <i>HYAL2</i> methylation and early-stage lung cancer: a case-control study. [PDF]

Lung Cancer Manag
Qiao R, Zhou X, Li W, Zhong R, Wang J, Song Y, Zhang J, Xu T, Wang Y, Dai L, Gu W, Han B, Yang R.   +12 more
europepmc   +1 more source