Results 241 to 250 of about 881,260 (340)

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, EarlyView.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Diagnostic value of multi-gene methylation in colorectal cancer screening. [PDF]

Front Oncol
Yang Q, Chen L.
europepmc   +1 more source

Stat stimulates histone H3K4 methylation via KDM5 inhibition in adult stem cells of budding tunicates [PDF]

Yuri Kimura‐Nagano, Kenji Kishimoto, Satoko Sekida, Kaz Kawamura   +3 more
openalex   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Integrative Analysis of DNA Methylome and Transcriptome Reveals the Mechanism of Heat Tolerance in Non-heading Chinese Cabbage. [PDF]

J Agric Food Chem
Zhao R, Zhu H, Yin Y, Yin M, Luo Y, Fang Y, Zhang D.   +6 more
europepmc   +1 more source

The CXXC-TET bridge — mind the methylation gap! [PDF]

, 2013
Donncha S. Dunican, Sari Pennings, Richard R. Meehan   +2 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Promoter Methylation-Expression Coupling of Gliogenesis Genes in <i>IDH</i>-Wildtype Glioblastoma: Longitudinal Analysis and Prognostic Value. [PDF]

Int J Mol Sci
Radu R, Tataranu LG, Dricu A, Alexandru O.   +3 more
europepmc   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

Identification and validation of <i>HOXB3</i> hypomethylation as a novel prognostically epigenetic biomarker in acute myeloid leukemia. [PDF]

Front Immunol
Zhang TJ, Chang R, Xie F, Xu ZJ, Chu MQ, Wu XC, Qian J, Zhou JD.   +7 more
europepmc   +1 more source