Results 261 to 270 of about 881,260 (340)

Mitochondrial epigenetic mechanisms in cancer: an updated overview. [PDF]

Front Cell Dev Biol
Stoccoro A, Coppedè F.
europepmc   +1 more source

Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia [PDF]

Markos Tesfaye, Letícia Spíndola, Anne-Kristin Stavrum, Alexey Shadrin, Ingrid Melle, Ole A. Andreassen, Stéphanie Le Hellard   +6 more
openalex   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

SARS-CoV-2 altered mitochondrial DNA methylation in Indian COVID-19 patients. [PDF]

Sci Rep
Kumari D, Singh S, Chauhan D, Dange K, Ganju L, Dogra V, Garg I, Srivastava S, Singh Y.   +8 more
europepmc   +1 more source

A Computational Investigation of Selective DNA Methylation

, 2008
Kaushalya S. Ekanayake
openalex   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Exploring the Impact of DNA Methylation on Gene Expression in CRC: A Computational Approach for Identifying Epigenetically Regulated Genes in Multi-Omic Datasets. [PDF]

Cancers (Basel)
Blindu AS, Berardelli S, De Paoli F, Manai F, Tricarico R, Zucca S, Magni P.   +6 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Regulation of RNA methylation linked to drug resistance in gastric cancer. [PDF]

Front Cell Dev Biol
Yang Z, Ma Y, Xu Z, Liu H, Gu X, Sun J.
europepmc   +1 more source