Results 271 to 280 of about 443,290 (339)

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +1 more source

Distinct cerebrospinal fluid DNA methylation signatures linked to Alzheimer’s disease

Rados M, Klotz S, Regelsberger G, Stögmann E, Landegger LD, Fetahu IS.   +5 more
europepmc   +1 more source

Noninvasive Multicancer Detection Using DNA Hypomethylation of LINE-1 Retrotransposons. [PDF]

Clin Cancer Res
Michel M, Heidary M, Mechri A, Da Silva K, Gorse M, Dixon V, von Grafenstein K, Bianchi C, Hego C, Rampanou A, Lamy C, Kamal M, Le Tourneau C, Séné M, Bièche I, Reyes C, Gentien D, Stern MH, Lantz O, Cabel L, Pierga JY, Bidard FC, Azencott CA, Proudhon C.   +23 more
europepmc   +1 more source

Tailored 3‐Alkoxy‐N,N,N,2,2‐Pentamethylpropan‐1‐Ammonium Bis(trifluoromethylsulfonyl)Imide Ionic Liquids for Room‐Temperature Fluoride‐Ion Batteries

Angewandte Chemie, EarlyView.
Two new quaternary ammonium TFSI ionic liquids, [MNPA][TFSI] and [NPPA][TFSI] were designed and synthesized. These ionic liquids readily dissolve quaternary ammonium fluorides (>0.7 M), and the resulting electrolytes have a wide operational voltage range (>5.4 V).
Tiancheng Tan, Richard Murdey, Shunsuke Sumitomo, Kazuyuki Sato, Takeshi Abe, Atsushi Wakamiya   +5 more
wiley   +1 more source

DNA methylation heterogeneity correlates with field cancerization and prognosis in lung adenocarcinoma patients. [PDF]

Clin Epigenetics
Zhou Y, Zhang J, He Y, Wang Y, Li B, Zhu T, Su Y.   +6 more
europepmc   +1 more source

Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal‐Organic Cages Towards Accelerated Discovery

Angewandte Chemie, EarlyView.
An automated experimental workflow to accelerate the discovery of metal‐organic cages (MOCs), which is often hindered by slow, manual approaches, has been developed. Automation of the synthesis, characterization, and analysis, is supported by computational modelling to rationalize the experimental outcomes, and development of a host–guest assay ...
Annabel R. Basford, Aaron H. Bernardino, Paula C. P. Teeuwen, Benjamin D. Egleston, Joshua Humphreys, Kim. E. Jelfs, Jonathan R. Nitschke, Imogen A. Riddell, Rebecca L. Greenaway   +8 more
wiley   +1 more source

Effects of Treatment with a DNA Methyltransferase Inhibitor 5-aza-dC on Sex Differentiation in Medaka (<i>Oryzias latipes</i>). [PDF]

Int J Mol Sci
Cui X, Xu L, Tian N, Peng J.
europepmc   +1 more source

Regio‐ and Enantioconvergent Hydroallylation of Acrylates Enabled by γ‐Silyl‐Substituted Allyl Acetates

Angewandte Chemie, EarlyView.
Regio‐ and enantioconvergent hydroallylation of acylates under Cu/Pd synergistic catalysis is reported. The incorporation of a silyl group into allyl acetates precisely controls regio‐ and enantioselectivity through steric hindrance. Subsequent transformation of the silyl group in the product enables the regioselective synthesis of allylated products ...
Hirotsugu Suzuki, Ryoichi Nishikawa, Yuki Sato, Kaisei Sekino, Takanori Matsuda   +4 more
wiley   +1 more source

Epigenome-wide methylation analysis shows phosphonoethylamine alleviates aberrant DNA methylation in NASH caused by Pcyt2 deficiency. [PDF]

PLoS One
Grapentine S, Agarwal P, Dolinsky VW, Bakovic M.   +3 more
europepmc   +1 more source

Total Synthesis of the Marine Diterpenoids Caucanolide E and F by Alkyne gem‐Hydrogenation: Rigorous Reassignment of Two Almost Indistinguishable Diastereomers

Angewandte Chemie, EarlyView.
The application of gem‐hydrogenation, which exploits the electrophilic character of the ruthenium carbene intermediates transiently formed, to natural product total synthesis allowed the stereostructure of a pair of diastereomeric seco‐cembranoids that are almost indistinguishable by NMR to be rigorously assigned.
Ricardo Molina Betancourt, Markus Leutzsch, Alois Fürstner   +2 more
wiley   +1 more source