Results 311 to 320 of about 1,050,423 (388)

Molecular triage on HPV-positive samples in a cervical screening setting. [PDF]

PLoS One
Larsson GL, Carlsson J, Helenius G, Bergengren L.   +3 more
europepmc   +1 more source

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

Advanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan, Lu Cui, Jakkapong Inchai, Zhuoqing Fang, Jacky Law, Alberto Alonzo Garcia Brito, Annalisa Pawlosky, Juraj Gottweis, Alexander Daryin, Artiom Myaskovsky, Lakshmi Ramakrishnan, Anil Palepu, Kavita Kulkarni, Wei‐Hung Weng, Zhuanfen Cheng, Vivek Natarajan, Alan Karthikesalingam, Keran Rong, Yunhan Xu, Tao Tu, Gary Peltz   +20 more
wiley   +1 more source

Using blood methylomes to predict response to amisulpride in the first-episode psychosis in the OPTiMiSE cohort. [PDF]

Transl Psychiatry
Lokmer A, Troudet R, Bacq-Daian D, Boland-Auge A, Barau C, OPTiMiSE study group, Deleuze JF, Leboyer M, Jamain S.   +8 more
europepmc   +1 more source

ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, ASH2L‐K312‐lac is identified as a critical driver that promotes the malignant progression of hepatocellular carcinoma (HCC). Furthermore, through a comprehensive series of cell biological and molecular biological experiments, integrated with diverse animal models and systematic application of high‐throughput sequencing technologies, it ...
Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, Cuixia Liu, Dakun Zhao, Xiangqian Gu, He Zhu, Yin Yuan   +14 more
wiley   +1 more source

Whole organism integrated DNA methylation and transcriptomics analysis of butterfly metamorphosis. [PDF]

Sci Rep
Hesketh A, Kadiwala J, Garizo AR, Beldade P, Shakur R.   +4 more
europepmc   +1 more source

Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science, EarlyView.
This study constructs a multi‐channel deep learning framework IntRNA to interpret RNA universe and coding potential. IntRNA consistently performed the best among existing methods in various benchmarks. Moreover, IntRNA’s interpretability is also validated by real‐world analysis, which found some features indicating long‐distance contact between ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
wiley   +1 more source

Influence of TPH2 DNA methylation and family functioning, parenting styles on OCD severity. [PDF]

BMC Psychiatry
Wang L, Chen Y, Hu S, Yu T, Liu Z, Qiao D.   +5 more
europepmc   +1 more source

ERβ/circAHNAK Axis Inhibits USP10–FMR1 Deubiquitination to Prevent m⁶A‐Mediated ADAM17 Decay and Promote Angiogenesis in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
In clear cell renal cell carcinoma, estrogen receptor β (ERβ) upregulates circAHNAK, which competitively binds USP10 to prevent FMR1 deubiquitination, leading to FMR1 degradation. Loss of FMR1 hinders m⁶A‐dependent decay of ADAM17 mRNA, resulting in ADAM17 accumulation in tumor exosomes and enhanced angiogenesis.
Chao Xu, Sujing Zhang, Yuepeng Liu, Jingwei Lv, Yilong Cao, Yao Chen, Hao Sun, Bowei Zhang, Shengtao Dai, Jiehan Li, Xiaoling Li, Bei Shi, Qingyun Sun, Meng Zhu, Junfei Gu   +14 more
wiley   +1 more source

Epigenetic control of the plant metabolome: implications for Chinese medicine. [PDF]

Chin Med
Hyun TK.
europepmc   +1 more source

Phospholipid methylation in macrophages is inhibited by chemotactic factors

, 1979
Marilyn C. Pike, Nicholas M. Kredich, Ralph Snyderman   +2 more
openalex   +1 more source