Results 61 to 70 of about 881,260 (340)

Structure, activity and function of the lysine methyltransferase SETD5

Frontiers in Endocrinology, 2023
SET domain-containing 5 (SETD5) is an uncharacterized member of the protein lysine methyltransferase family and is best known for its transcription machinery by methylating histone H3 on lysine 36 (H3K36).
Mingyang Li, Yanan Hou, Ziwei Zhang, Bowen Zhang, Ting Huang, Aiqin Sun, Genbao Shao, Qiong Lin   +7 more
doaj   +1 more source

Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts [PDF]

, 2017
During the transit through the oviduct, the early embryo initiates an extensive DNA methylation reprogramming of its genome. Given that these epigenetic modifications are susceptible to environmental factors, components present in the oviductal milieu ...
Barrera, Antonio Daniel, Fonseca Balvís, Noelia, Garcia, Elina Vanesa, Gutiérrez Adan, Alfonso, Hamdi, Meriem, López Cardona, Ángela Patricia, Rizos, Dimitrios, Sánchez Calabuig, María Jesús   +7 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
core   +3 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis [PDF]

, 2011
Background\ud DNA methylation is an epigenetic mechanism associated with regulation of gene expression and it is modulated during chemical carcinogenesis.
Chipman, J Kevin, Gong, Zhiyuan, Mirbahai, Leda, Williams, Timothy D, Zhan, Huiqing   +4 more
core   +4 more sources

Methyl 4-(butyrylamino)-5-methyl-2-nitrobenzoate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The title compound, C(13)H(16)N(2)O(5), is useful as an inter-mediate in the field of agrochemicals. Intra-molecular C-H⋯O hydrogen bonds result in the formation of one six- and one five-membered nearly planar ring; the six-membered ring is also nearly coplanar with the adjacent benzene ring.
Cheng Yao, Xiang Li, Lian-shan Yuan
openaire   +3 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Stability of Blood DNA Methylation Across Two Timepoints in Three Cohorts

Biomedicines
Background: DNA methylation mediates the gene–environment interactions, with implications for health and disease. Studies with sampling at more than one timepoint revealed the considerable variability of the blood methylome, but comprehensive resources ...
Mikołaj Danielewski, Jarosław Walkowiak, Karolina Wielgus, Jan Krzysztof Nowak   +3 more
doaj   +1 more source

The Landscape of Iron Metabolism-Related and Methylated Genes in the Prognosis Prediction of Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2020
Background: Clear cell renal cell carcinoma (ccRCC) is characteristics of resistance to chemotherapy and radiotherapy. The prognosis of ccRCC was dismay with immense diversity. Iron metabolism disturbance is a common phenomenon in ccRCC.
Yanhua Mou, Yanhua Mou, Yao Zhang, Jinchun Wu, Busheng Hu, Chunfang Zhang, Chaojun Duan, Chaojun Duan, Bin Li, Bin Li   +9 more
doaj   +1 more source