Results 61 to 70 of about 1,050,423 (388)

PRMT5 Enables Robust STAT3 Activation via Arginine Symmetric Dimethylation of SMAD7

Advanced Science, 2021
Protein arginine methyltransferase 5 (PRMT5) is the type II arginine methyltransferase that catalyzes the mono‐ and symmetrical dimethylation of protein substrates at the arginine residues.
Congcong Cai, Shuchen Gu, Yi Yu, Yezhang Zhu, HanChenxi Zhang, Bo Yuan, Li Shen, Bing Yang, Xin‐Hua Feng   +8 more
doaj   +1 more source

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma [PDF]

, 2015
Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers.
, Berbegall, Ana P., Bienertova-Vasku, Julie, Bown, Nick, Cannoodt, Robrecht, Clément, Nathalie, Combaret, Valérie, De Preter, Katleen, De Wilde, Bram, Decock, Anneleen, Haber, Michelle, Hoyoux, Claire, Laureys, Geneviève, Murray, Jayne, Noguera, Rosa, Ongenaert, Maté, Pierron, Gaelle, Schleiermacher, Gudrun, Schulte, Johannes H., Speleman, Frank, Stallings, Ray L., Tweddle, Deborah A., Van Roy, Nadine, Vandesompele, Jo, Verniers, Kimberly   +24 more
core   +2 more sources

Methylation of demethylavermectins [PDF]

Antimicrobial Agents and Chemotherapy, 1987
Demethylavermectins, which lack methyl groups on the oleandrose moiety, were fed to wild-type "Streptomyces avermitilis," which produces the normal avermectin components, and the bioconversion products were identified. The oleandrose units of the demethylavermectins were not methylated by the wild-type strain, but the C-5 of the macrolide ring was ...
M D Schulman, C Ruby
openaire   +3 more sources

Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis

Frontiers in Pharmacology
ObjectiveNoise-induced hearing loss (NIHL), resulting from occupational noise exposure, is a significant health concern with considerable economic and social implications.
Dianpeng Wang, Dianpeng Wang, Caiping Li, Caiping Li, Liuwei Shi, Liuwei Shi, Dafeng Lin, Shaofan Weng, Xiangli Yang, Peimao Li, Zhimin Zhang, Wen Zhang, Yan Guo, Guangtao Yang, Zhenlie Huang, Naixing Zhang   +15 more
doaj   +1 more source

Cyclophosphamide Exposure Causes Long-Term Detrimental Effect of Oocytes Developmental Competence Through Affecting the Epigenetic Modification and Maternal Factors’ Transcription During Oocyte Growth

Frontiers in Cell and Developmental Biology, 2021
Cyclophosphamide (CTX) is widely used in various cancer therapies and in immunosuppression, and patients can still have babies after CTX chemotherapy.
Weijie Yang, Weijie Yang, Yerong Ma, Yerong Ma, Jiamin Jin, Jiamin Jin, Peipei Ren, Peipei Ren, Hanjing Zhou, Hanjing Zhou, Shiqian Xu, Shiqian Xu, Yingyi Zhang, Yingyi Zhang, Zhanhong Hu, Zhanhong Hu, Yan Rong, Yan Rong, Yongdong Dai, Yongdong Dai, Yinli Zhang, Yinli Zhang, Songying Zhang, Songying Zhang   +23 more
doaj   +1 more source

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

Homocysteine Metabolism in Pregnancy and Developmental Impacts

Frontiers in Cell and Developmental Biology, 2022
Homocysteine is a metabolite generated by methionine cycle metabolism, comprising the demethylated derivative of methionine. Homocysteine can be metabolised by the transsulphuration pathway to cystathionine, which requires vitamin B6, or can undergo ...
Stephen W. D’Souza, Jocelyn D. Glazier
doaj   +1 more source

Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]

, 2014
peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core   +2 more sources

The Toxicity of Methylal [PDF]

Occupational and Environmental Medicine, 1951
dimethoxymethane, formaldehyde dimethyl acetal and m?thyl?ne dimethyl ether, the simplest of the group of acet?is, can be prepared very simply by the interaction of formaldehyde and methanol catalyzed by dry hydrogen chloride or even by calcium chloride, ft is a clear, thin, mobile liquid, lighter than water, and soluble in water to the extent of one ...
Frank L. Weaver, Alan R. Hough, Benjamin Highman, Lawrence T. Fairhall   +3 more
openaire   +3 more sources

Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5

Frontiers in Oncology
BackgroundLaryngeal cancer is a common head and neck cancer, and its occurrence and development are closely related to a variety of epigenetic modifications.
Linlu Li, Jiao Cui, Xiaoyu Li, Yuting Zhu, Hongfei Wu, Lanzhu Zhou   +5 more
doaj   +1 more source