Results 61 to 70 of about 1,069,555 (390)

Interferon beta treatment is a potent and targeted epigenetic modifier in multiple sclerosis

Frontiers in Immunology, 2023
IntroductionMultiple Sclerosis (MS) has a complex pathophysiology that involves genetic and environmental factors. DNA methylation (DNAm) is one epigenetic mechanism that can reversibly modulate gene expression.
Alexandre Xavier, Maria Pia Campagna, Vicki E. Maltby, Vicki E. Maltby, Vicki E. Maltby, Trevor Kilpatrick, Bruce V. Taylor, Helmut Butzkueven, Helmut Butzkueven, Anne-Louise Ponsonby, Rodney J. Scott, Rodney J. Scott, Vilija G. Jokubaitis, Rodney A. Lea, Rodney A. Lea, Jeannette Lechner-Scott, Jeannette Lechner-Scott, Jeannette Lechner-Scott   +17 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Methylation characteristics and clinical significance of glutathione peroxidase 3 in malignant pleomorphic adenoma

Kouqiang hemian waike zazhi
[Objective:] To observe the methylation and protein levels of glutathione peroxidase 3 (GPX3) in malignant pleomorphic adenoma (MPA) tissue and its clinical significance.
LIU Xiao, SUN Jiangwei, ZHOU Jing
doaj   +1 more source

Different hydrogen-bonded chains in the crystal structures of three alkyl N-[(E)-1-(2-benzylidene-1-methylhydrazinyl)-3-hydroxy-1-oxopropan-2-yl]carbamates

Acta Crystallographica Section E: Crystallographic Communications, 2015
The crystal structures of three methylated hydrazine carbamate derivatives prepared by multi-step syntheses from l-serine are presented, namely benzyl N-{(E)-1-[2-(4-cyanobenzylidene)-1-methylhydrazinyl]-3-hydroxy-1-oxopropan-2-yl}carbamate, C20H20N4O4 ...
Thais C. M. Noguiera, Alessandra C. Pinheiro, James L. Wardell, Marcus V. N. de Souza, Jordan P. Abberley, William T. A. Harrison   +5 more
doaj   +1 more source

Relationship between cognitive dysfunction and the promoter methylation of PER1 and CRY1 in patients with cerebral small vessel disease

Frontiers in Aging Neuroscience, 2023
Background and purposeThe prevalence of cerebral small vessel disease (CSVD) is increasing due to the accelerating global aging process, resulting in a substantial burden on all countries, as cognitive dysfunction associated with CSVD is also on the rise.
Yiwen Xu, Yugang Wang, Yi Jiang, Mengqian Liu, Wen Zhong, Zhonglin Ge, Zhichao Sun, Xiaozhu Shen   +7 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]

, 2014
peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core   +2 more sources

Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma

Frontiers in Genetics, 2023
Background: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been previously observed, a genome-wide, single-base-resolution,
Weizhi Zhao, Weizhi Zhao, Lin Zhu, Lin Zhu, Qian Gong, Qian Gong, Suzhen Ma, Suzhen Ma, Haofeng Xiong, Tong Su, Zhengqing Wan, Zhengqing Wan, Danling Wang, Danling Wang, Danling Wang   +14 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes

Cancer Medicine
Introduction Men with African ancestry have the highest incidence and mortality rates of prostate cancer (PCa) worldwide. Methods This study aimed to identify differentially methylated genes between tumor vs. adjacent normal and aggressive vs.
Anders Berglund, Kosj Yamoah, Steven A. Eschrich, Rana Falahat, James J. Mulé, Sungjune Kim, Jaime Matta, Julie Dutil, Gilberto Ruiz‐Deya, Carmen Ortiz Sanchez, Liang Wang, Hyun Park, Hirendra N. Banerjee, Tamara Lotan, Kathryn Hughes Barry, Ryan M. Putney, Seung Joon Kim, Clement Gwede, Jacob K. Kresovich, Youngchul Kim, Hui‐Yi Lin, Jasreman Dhillon, Ratna Chakrabarti, Jong Y. Park   +23 more
doaj   +1 more source