Results 211 to 220 of about 134,759 (258)

Mechanisms of resistance to DNA methylation damage in human cells

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Histone methylation and the DNA damage response [PDF]

Mutation Research - Reviews in Mutation Research, 2019
Preserving genome function and stability are paramount for ensuring cellular homeostasis, an imbalance in which can promote diseases including cancer. In the presence of DNA lesions, cells activate pathways referred to as the DNA damage response (DDR). As nuclear DNA is bound by histone proteins and organized into chromatin in eukaryotes, DDR pathways ...
Kyle Miller, Fade Gong
exaly   +3 more sources

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The role of arginine methylation in the DNA damage response

DNA Repair, 2013
Post-translational modifications are well-known modulators of DNA damage signaling and epigenetic gene expression. Protein arginine methylation is a covalent modification that results in the addition of methyl groups to the nitrogen atoms of the arginine side chains and is catalyzed by a family of protein arginine methyltransferases (PRMTs).
Stéphane Richard
exaly   +3 more sources

The repair of DNA methylation damage in Saccharomyces cerevisiae

Current Genetics, 1996
The major genotoxicity of methyl methanesulfonate (MMS) is due to the production of a lethal 3-methyladenine (3MeA) lesion. An alkylation-specific base-excision repair pathway in yeast is initiated by a Mag1 3MeA DNA glycosylase that removes the damaged base, followed by an Apn1 apurinic/ apyrimidinic endonuclease that cleaves the DNA strand at the ...
W, Xiao, B L, Chow, L, Rathgeber
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Methylation damage response in hematopoietic progenitor cells

DNA Repair, 2007
The cellular response to methylation DNA damage was compared in multipotent CD34(+) hematopoietic stem cells and mature CD34(-) cells isolated from cord blood of the same donor. Cytofluorimetric analysis of freshly isolated cord blood cells indicated that both cell types were in the G0/G1 phase of the cell cycle.
Ida, Casorelli, Elvira, Pelosi, Mauro, Biffoni, Anna Maria, Cerio, Cesare, Peschle, Ugo, Testa, Margherita, Bignami   +6 more
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Repairing DNA-methylation damage

Nature Reviews Molecular Cell Biology, 2004
Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism.
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DNA replication arrest and tolerance to DNA methylation damage

Carcinogenesis, 1994
Inhibition of DNA replication by different DNA damaging agents has been investigated in HeLaMR cells and a methylation damage-tolerant variant HeLa5A1. In synchronous HeLaMR and HeLa5A1 cells exposed to N-ethyl-N-nitrosourea or ionizing radiation in mid-G1 phase, DNA synthesis was inhibited in the following S phase.
N, Zhukovskaya, P, Branch, G, Aquilina, P, Karran   +3 more
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Repair of DNA damaged by methyl methanesulfonate in bacteriophage T4

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
A highly purified preparation of T4 endonuclease V does not degrade DNA alkylated with methyl methanesulfonate, and the methyl methanesulfonate sensitivity of T4 wild type and x mutant is not affected by the v mutation. Thus, T4 endonuclease V, the v gene product, does not seem to be involved in a repair or an abortive repair of methyl methanesulfonate-
Y, Nishida, S, Yasuda, M, Sekiguchi
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Methylating agents damage DNA

C&EN Global Enterprise, 2018
Exposure to methylating agents, which are used in the lab and in chemotherapy, can cause an unexpected form of DNA damage, a new study reveals.
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