Results 231 to 240 of about 2,934,821 (333)

The regulation of oxidative stress response by epigenetic modifications in acute respiratory distress syndrome. [PDF]

J Thorac Dis
Ma P, Jia L, Zhang H, Yu J, Cao L, Zhang N, Zhao T.   +6 more
europepmc   +1 more source

DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different

Journal of Neuropathology and Experimental Neurology, 2018
L. Martin, Qing Chang
semanticscholar   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Disruption of DNA Repair as an Emerging Epigenetic Mechanism Underlying Autism Spectrum Disorder. [PDF]

Curr Psychiatry Rep
Kelvington B, Kim J, Banerjee S, Stevens HE, Chow KH, Abel T.   +5 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Resolving Oxidative and Corrosive Calendar‐Aging via Electrolyte Engineering for Stable Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
A weakly solvating ether solvent, 1,2‐dimethoxypropane (DMP), is proposed for use in localized high‐concentration electrolytes (LHCEs) for lithium metal batteries (LMBs). These DMP‐based LHCEs simultaneously suppress lithium metal corrosion and cathode degradation—two interrelated processes that accelerate calendar aging of LMBs.
Jisub Kim, Ihnkyung Jung, Kyunam Lee, Insu Hwang, Minkwan Kim, Eunseok Park, Dongmin Park, Hayoung Park, Yonggoon Jeon, Gaeun Park, Hyo Chul Ahn, Jihoon Oh, Jungwon Park, Ali Coskun, Jang Wook Choi   +14 more
wiley   +1 more source

Therapeutic implications of epigenetic alterations in burns: a new frontier in burn medicine. [PDF]

Clin Sci (Lond)
Timpano S, Farahat M, Jeschke MG.
europepmc   +1 more source

Fermented Citrus as a Functional Food Matrix: Evaluating Probiotic, Prebiotic, and Postbiotic Potential

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Fermented citrus transforms bioactive compounds into metabolites with probiotic and prebiotic properties, enhancing gut health, immunity, and metabolic balance. This review highlights fermentation's role in developing sustainable, health‐promoting functional foods while addressing challenges in process optimization, sensory quality, and commercial ...
Sony Kumari, Rahel Debbarma, Shakil Haque, Himalay Baruah   +3 more
wiley   +1 more source

Epigenetic regulation in cancer chemoresistance and combined therapeutic strategies. [PDF]

Front Cell Dev Biol
Jiang L, Yuan Y, Zhang D, Wang J, Jiang X, Shi Y.   +5 more
europepmc   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source