Results 251 to 260 of about 2,934,821 (333)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. [PDF]

J Biomed Sci
Jeong Y, Cho Y, Kim YK.
europepmc   +1 more source

Assessment of radiotherapy effect and toxicity using tissue-associated DNA methylation markers in cell-free DNA: a study on prostate cancer. [PDF]

Radiat Environ Biophys
Bahtiyar N, Mermut O, Firtina S, Ozaydin A, Suleymanova A, Isikgil B, Onaran İ.   +6 more
europepmc   +1 more source

Post-translational modifications in retinoblastoma: mechanisms, immune regulation, and therapeutic opportunities. [PDF]

Front Immunol
Xu L, Wang B, Li W, Luo X, Wang L, Zheng Y.   +5 more
europepmc   +1 more source

A cost‐effective DNA extraction protocol for long‐read sequencing in non‐model plants

Applications in Plant Sciences, EarlyView.
Abstract Premise Third‐generation sequencing has revolutionized genomics, enabling in‐depth analysis of genome sequence, structure, and epigenetic features. Yet, extracting high‐quality DNA for long‐read sequencing remains a bottleneck—particularly in non‐model plants, such as mature trees growing in natural environments, which often contain abundant ...
Sofia Gaischuk, Cintia F. Marchetti, Ezequiel Petrillo, Fernando A. Rabanal, Detlef Weigel, Nicolás Bellora, M. Verónica Arana   +6 more
wiley   +1 more source

PRMT5 in mitochondria regulates mtDNA stability through TFAM arginine methylation. [PDF]

Nat Commun
Bhattacharjee S, Das S, Chowdhury B, Das BB.   +3 more
europepmc   +1 more source

Heat Stress in Quail: Impacts on Health and Productivity, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts physiological homeostasis in quail, inducing oxidative stress, immune dysregulation, and metabolic imbalance, which impair growth, reproduction, product quality, and welfare. Integrating nutritional, environmental, and genetic–epigenetic strategies enhances thermotolerance, sustains productivity, and supports climate‐smart quail ...
T. A. Eletu, I. A. Anjola, L. O. Fasasi, D. P. Fadipe, A. T. Afuye, F. O. Fasanya, O. E. Oke   +6 more
wiley   +1 more source

Epigenetic drug control of Clec4g/LSECtin expression reduces fibrosis burden in cirrhosis. [PDF]

Hepatol Commun
Ángel-Gomis E, Gómez-Hurtado I, Fernández-Barrena MG, Juanola O, Martínez-López S, Boix P, Ávila MA, Caparrós E, Francés R.   +8 more
europepmc   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Arginine methylation of human DNA topoisomerase I by PRMT5 facilitates DNA relaxation. [PDF]

Nucleic Acids Res
Basu S, Bhattacharyya A, Khan MA, Pal U, Chowdhuri SP, Satrusal SR, Baranello L, Datta D, Das BB.   +8 more
europepmc   +1 more source