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Mechanisms of resistance to DNA methylation damage in human cells

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The repair of DNA methylation damage in Saccharomyces cerevisiae

Current Genetics, 1996
The major genotoxicity of methyl methanesulfonate (MMS) is due to the production of a lethal 3-methyladenine (3MeA) lesion. An alkylation-specific base-excision repair pathway in yeast is initiated by a Mag1 3MeA DNA glycosylase that removes the damaged base, followed by an Apn1 apurinic/ apyrimidinic endonuclease that cleaves the DNA strand at the ...
W, Xiao, B L, Chow, L, Rathgeber
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Methylation damage response in hematopoietic progenitor cells

DNA Repair, 2007
The cellular response to methylation DNA damage was compared in multipotent CD34(+) hematopoietic stem cells and mature CD34(-) cells isolated from cord blood of the same donor. Cytofluorimetric analysis of freshly isolated cord blood cells indicated that both cell types were in the G0/G1 phase of the cell cycle.
Ida, Casorelli, Elvira, Pelosi, Mauro, Biffoni, Anna Maria, Cerio, Cesare, Peschle, Ugo, Testa, Margherita, Bignami   +6 more
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The role of arginine methylation in the DNA damage response

DNA Repair, 2013
Post-translational modifications are well-known modulators of DNA damage signaling and epigenetic gene expression. Protein arginine methylation is a covalent modification that results in the addition of methyl groups to the nitrogen atoms of the arginine side chains and is catalyzed by a family of protein arginine methyltransferases (PRMTs).
Yannick, Auclair, Stéphane, Richard
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Repairing DNA-methylation damage

Nature Reviews Molecular Cell Biology, 2004
Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism.
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DNA replication arrest and tolerance to DNA methylation damage

Carcinogenesis, 1994
Inhibition of DNA replication by different DNA damaging agents has been investigated in HeLaMR cells and a methylation damage-tolerant variant HeLa5A1. In synchronous HeLaMR and HeLa5A1 cells exposed to N-ethyl-N-nitrosourea or ionizing radiation in mid-G1 phase, DNA synthesis was inhibited in the following S phase.
N, Zhukovskaya, P, Branch, G, Aquilina, P, Karran   +3 more
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Repair of DNA damaged by methyl methanesulfonate in bacteriophage T4

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
A highly purified preparation of T4 endonuclease V does not degrade DNA alkylated with methyl methanesulfonate, and the methyl methanesulfonate sensitivity of T4 wild type and x mutant is not affected by the v mutation. Thus, T4 endonuclease V, the v gene product, does not seem to be involved in a repair or an abortive repair of methyl methanesulfonate-
Y, Nishida, S, Yasuda, M, Sekiguchi
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