Results 291 to 300 of about 2,934,821 (333)

DNA replication arrest and tolerance to DNA methylation damage

Carcinogenesis, 1994
Inhibition of DNA replication by different DNA damaging agents has been investigated in HeLaMR cells and a methylation damage-tolerant variant HeLa5A1. In synchronous HeLaMR and HeLa5A1 cells exposed to N-ethyl-N-nitrosourea or ionizing radiation in mid-G1 phase, DNA synthesis was inhibited in the following S phase.
N, Zhukovskaya, P, Branch, G, Aquilina, P, Karran   +3 more
openaire   +2 more sources

Repair of DNA damaged by methyl methanesulfonate in bacteriophage T4

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
A highly purified preparation of T4 endonuclease V does not degrade DNA alkylated with methyl methanesulfonate, and the methyl methanesulfonate sensitivity of T4 wild type and x mutant is not affected by the v mutation. Thus, T4 endonuclease V, the v gene product, does not seem to be involved in a repair or an abortive repair of methyl methanesulfonate-
Y, Nishida, S, Yasuda, M, Sekiguchi
openaire   +2 more sources

INVESTIGATING METHYL BROMIDE DAMAGE OF 'FUJI' APPLES

Acta Horticulturae, 2003
Tasmania’s fruit fly free status has allowed the Tasmanian apple industry access to the lucrative Japanese market after the development of a fumigation protocol for the elimination of codling moth. This protocol was developed over a ten year period and access to the market was obtained in 1999.
L. Schimanski, G. Brown
openaire   +1 more source

Methylating agents damage DNA

C&EN Global Enterprise, 2018
Exposure to methylating agents, which are used in the lab and in chemotherapy, can cause an unexpected form of DNA damage, a new study reveals.
openaire   +1 more source

Neuroinflammation markers and methyl alcohol induced toxic brain damage

Toxicology Letters, 2018
Methyl alcohol intoxication is a global problem with high mortality and long-term visual sequelae and severe brain damage in survivors. The role of neuroinflammation in the mechanisms of methyl alcohol-induced toxic brain damage has not been well studied.
Sergey Zakharov, Jiri Hlusicka, Olga Nurieva, Katerina Kotikova, Lucie Lischkova, Petr Kacer, Tereza Kacerova, Pavel Urban, Manuela Vaneckova, Zdenek Seidl, Pavel Diblik, Pavel Kuthan, Jarmila Heissigerova, Jiri Lesovsky, Jan Rulisek, Lucie Vojtova, Jaroslav A. Hubacek, Tomas Navratil   +17 more
openaire   +3 more sources

Damage induced by methyl methanesulfonate (MMS) inChlamydomonas reinhardi

Zeitschrift f�r Vererbungslehre, 1966
In order to get information about the mechanism of action of alkylating agents, survival was studied after treatment with methyl methanesulfonate, in an arginine-requiring strain of the unicellular green algaChlamydomonas reinhardi. Methylated cells are susceptible to further degradation if they are allowed to stand at ordinary temperature and are ...
openaire   +2 more sources

Genetic consequences of tolerance to methylation DNA damage in mammalian cells

Carcinogenesis, 1993
We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in the parental and clone B cells ...
G, Aquilina, R, Biondo, E, Dogliotti, M, Bignami   +3 more
openaire   +2 more sources

Cellular Responses to Methylation Damage

1998
The study of DNA methylation damage and the cellular response to methylation damage has contributed significantly to our understanding of cell function. The mutagenicity of DNA methylating agents, such as methyl methane sulfonate (MMS) and 1-methyl-l -nitrosourea (MNU), is widely appreciated, and is useful in creating mutants in bacterial and human ...
openaire   +1 more source

Repair of methyl methane sulfonate-damaged phage by Haemophilus influenzae

Molecular and General Genetics MGG, 1983
Seven mutants of Haemophilus influenzae strain Rd (mmsA-) have been isolated that are more sensitive to methyl methane sulfonate (mms) than recombination-deficient (recA-) mutants. The mutations cotransformed about 25% with the strA locus while the five studied clustered tightly; they are all probably allelic.
J H, Stuy, H, Bagci
openaire   +2 more sources

OGG1 methylation mediated the effects of cell cycle and oxidative DNA damage related to PAHs exposure in Chinese coke oven workers.

Chemosphere, 2019
Previous publications have indicated that polycyclic aromatic hydrocarbons (PAHs) exposures are associated with increased DNA damage and abnormal cell cycle arrest; however, the details of mechanisms remain largely unknown.
Ye Fu, Yingying Niu, B. Pan, Yanli Liu, Bin Zhang, Xuejing Li, A. Yang, J. Nie, Ruisheng Wang, Jin Yang   +9 more
semanticscholar   +1 more source