Results 41 to 50 of about 49,335 (246)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Gas Sensing With Aerogels: A Critical Review on Structure‐Property Correlations and Performance Optimization

Advanced Science, EarlyView.
With high specific surface area, and adjustable interface, aerogel provides a multi‐functional platform for gas sensing. This review systematically links structural parameters (specific surface area, pore size, heterojunctions) to sensing metrics (sensitivity, selectivity, stability), critically evaluates optimization strategies, and outlines future ...
Hao Guo, Linheng He, Qinxin Wang, Man Yuan, Shoutian Qiu, Wei Liu, Sheng Cui   +6 more
wiley   +1 more source

Methylcellulose and lens implantation. [PDF]

British Journal of Ophthalmology, 1983
Methylcellulose has been used since 1976 to prevent damage to the corneal endothelium during operations for implantation of intraocular lenses. Originally one drop of a 1% solution was placed on the artificial lens just before its insertion. Later the anterior chamber was completely filled with a 2% solution of methylcellulose before implantation.
P U, Fechner, M U, Fechner
openaire   +2 more sources

Maternal‐Fetal Administration of Risdiplam Partially Rescues the SMNΔ7 Mouse Model of Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Spinal muscular atrophy (SMA) is caused by deletions or mutations in the survival motor neuron 1 (SMN1) gene and subsequent reduction in the expression of survival motor neuron (SMN) protein. The disease is characterized by degeneration of α motor neurons and subsequent muscle atrophy.
Emma R. Sutton, Ariane Beauvais, Rebecca Yaworski, Hugh J. McMillan, Rashmi Kothary   +4 more
wiley   +1 more source

Smart Temperature‐Sensitive Injectable Methylcellulose‐Based Hydrogels: Design and Optimization for Sustained Drug Release

View
Methylcellulose (MC)‐based thermoresponsive hydrogels have recently emerged as effective materials for the controlled and sustained release of pharmaceutical agents. This is mainly due to the thermoresponsive properties of MC, which exhibits a unique sol
Francesca Persano, Leonardo Lamanna, Marco Friuli, Andrea Claudio Stetco, Amilcare Barca, Tiziano Verri, Cosimino Malitesta, Christian Demitri, Elisabetta Mazzotta   +8 more
doaj   +1 more source

Natural Aging of Biomaterials in Ambient and Physiological Environments

Advanced NanoBiomed Research, EarlyView.
Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley   +1 more source

Development of a Photothermally Polymerized Gelatin/Poly(ethyleneglycol)Dimethacrylate/Methylcellulose Hydrogel for Sustained Carbenicillin Delivery in Chronic Wound Healing

Nano Select
Chronic wounds pose significant healthcare challenges due to their susceptibility to infection and impaired healing. The complexity of managing such wounds is exacerbated by colonization with diverse microorganisms, including Staphylococcus aureus ...
Sara Labbate, Paola Gavazzo, Riccardo Manfredi, Roberto Utzeri, Giorgio Luciano, Maurizio Vignolo, Cristina D'Arrigo, Denise Galante   +7 more
doaj   +1 more source

Development and Characterization of Collagen–Methylcellulose Sponge-like Matrices for Indomethacin Release in Wound Dressing Applications

Pharmaceuticals
Background: Interest in advanced wound dressings for clinical applications is increasing, with biopolymer-based formulations emerging as an effective strategy for wound management.
Maria-Teodora Pițuru, Mădălina Georgiana Albu Kaya, Denisa Ioana Udeanu, Cristina Elena Dinu-Pîrvu, Elena-Emilia Tudoroiu, Ioana Luca, Lăcrămioara Popa, Valentina Anuța, Zina Vuluga, Bruno Ștefan Velescu, George Mihail Teodorescu, Elena Denisa Trandafir, Mihaela Violeta Ghica   +12 more
doaj   +1 more source