Results 81 to 90 of about 95,722 (324)
Preclinical correction of human Fanconi anemia complementation group A bone marrow cells using a safety-modified lentiviral vector. [PDF]
, 2010 One of the major hurdles for the development of gene therapy for Fanconi anemia (FA) is the increased sensitivity of FA stem cells to free radical-induced DNA damage during ex vivo culture and manipulation.
Adair, J +10 more
core +2 more sources
Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects
Animal Models and Experimental Medicine, EarlyView.Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu +12 more
wiley +1 more source
TET2 inhibits differentiation of embryonic stem cells but does not overcome methylation-induced gene silencing [PDF]
, 2014 TET2 is a methylcytosine dioxygenase that is frequently mutated in myeloid malignancies, notably myelodysplasia and acute myeloid leukemia. TET2 catalyses the conversion of 5′-methylcytosine to 5′-hydroxymethylcytosine within DNA and has been implicated ...
Chevassut, Timothy +2 more
core +3 more sources
Natural Aging of Biomaterials in Ambient and Physiological Environments
Advanced NanoBiomed Research, EarlyView.Biomaterials used in biomedical applications can change their physical properties over time, even under ambient and physiological conditions. This review highlights key studies on the natural aging of materials ranging from soft hydrogels to metals and ceramics, emphasizing how time‐dependent changes influence function and performance.
Shuyu Zhang, Anne E. Staples
wiley +1 more source
ViewMethylcellulose (MC)‐based thermoresponsive hydrogels have recently emerged as effective materials for the controlled and sustained release of pharmaceutical agents. This is mainly due to the thermoresponsive properties of MC, which exhibits a unique sol
Francesca Persano +8 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Key demographic, biological, and material considerations that drive the need for advanced injectable bone cement technologies. Injectable bone cements (IBCs) are widely used in orthopaedic and craniofacial applications due to their minimally invasive delivery and ability to provide early mechanical stabilisation.
Frank Fei +2 more
wiley +1 more source
A Methylcellulose Hydrogel as Support for 3D Plotting of Complex Shaped Calcium Phosphate Scaffolds
Gels, 2018 3D plotting is an additive manufacturing technology enabling biofabrication, thus the integration of cells or biologically sensitive proteins or growth factors into the manufacturing process.
Tilman Ahlfeld +4 more
doaj +1 more source
Identification of a lineage of multipotent hematopoietic progenitors [PDF]
, 1997 All multipotent hematopoietic progenitors in C57BL-Thy-1.1 bone marrow are divided among three subpopulations of Thy-1.1^(lo) Sca-1^+ Lin^(-/lo) c-kit^+ cells: long-term reconstituting Mac-1^-CD4^-c-kit^+ cells and transiently reconstituting Mac-1^(lo ...
Hemmanti, Houman D. +4 more
core
Nano SelectChronic wounds pose significant healthcare challenges due to their susceptibility to infection and impaired healing. The complexity of managing such wounds is exacerbated by colonization with diverse microorganisms, including Staphylococcus aureus ...
Sara Labbate +7 more
doaj +1 more source
Cryopreservation of cells using defined serum-free cryoprotective agents
Current Directions in Biomedical Engineering, 2016 For regenerative purposes, there is a high demand for viable and active cells. A big issue is to have enough viable cells available at any given time. One solution is cryopreservation.
Volbers Jan-Cedric +3 more
doaj +1 more source