Results 21 to 30 of about 9,036 (155)

Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer [PDF]

, 2011
Irinotecan and 5-fluorouracil (5-FU) are used to treat metastatic colorectal cancer. Irinotecan's active metabolite is inactivated by UDP-glucuronosyltransferase 1A1 (UGT1A1), which is deficient in Gilbert's syndrome.
A Jakobsen, A Ruzzo, B Glimelius, B Glimelius, B Glimelius, B Glimelius, C Massacesi, CY Liu, D Kweekel, DM Kweekel, E Cecchin, E Marcuello, E Rouits, E Van Cutsem, E Wasserman, F Innocenti, F Innocenti, F Innocenti, G Monaghan, G Toffoli, H Garmo, H Kohnke, H Sorbye, H Sørbye, J Mercke Odeberg, JF Cote, JF Deeken, JM Hoskins, JY Han, JY Han, K Robien, K Robien, K Sai, K Sai, K Saito, L A Fredriksson, L Iyer, L Iyer, L Iyer, L Paoluzzi, LE Carlini, M Ando, M Berglund, M Holthe, M Stephens, M Wadelius, MG Fakih, MJ Ratain, N Horie, P Byström, P Therasse, R Ihaka, RH Mathijssen, RZ Romero, S Funke, TE Klein, TW Kim, W Cao, Y Ando, Y Saito, Å Berglund   +60 more
core   +2 more sources

Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta‐analysis

Journal of Gene Medicine, 2019
The present study focused on understanding the prognostic value of the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms rs1801133 (C667T) and rs1801131 (A1298C) in patients with colorectal cancer (CRC).
Xin-lin Chen, Yu-Mei Wang, Fei Zhao, Zheng Chen, Xiaofei Yang, Cong Sun, Yunpeng Gao, Tian Yang, Tian Guo, Yi-ming Chen, Shui-lian Zhu, Xiao-Bing Lin, Feng-bin Liu   +12 more
semanticscholar   +1 more source

Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age [PDF]

, 2019
BACKGROUND: Riboflavin is required for several redox reactions. Clinical riboflavin deficiency occurs mainly in low-income countries, where it is associated with anemia. The functional significance of suboptimal riboflavin status in different populations
Aljaadi, Abeer, Barr, S I, Devlin, A M, Green, Tim, How, R E, Hunt, Shannon, Karakochuk, C. D., Khor, G L, Loh, S P, McAnena, Liadhan Brigid, McNulty, H, Ward, M   +11 more
core   +2 more sources

The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population

Medical archives, 2018
Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism.
H. Nefic, Mirela Mackic-Djurovic, Izet Eminovic   +2 more
semanticscholar   +1 more source

Correlations between methylenetetrahydrofolate reductase gene polymorphisms and venous thromboembolism: A meta-analysis of 99 genetic association studies

European Journal of Preventive Cardiology, 2018
We performed this meta-analysis to better assess the relationship between methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and the risk of venous thromboembolism. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science.
J. Zeng, Qinghua Zeng
semanticscholar   +1 more source

Association of anticardiolipin antibody and C677T in methylenetetrahydrofolate reductase mutation in women with recurrent spontaneous abortions: a new path to thrombophilia?

São Paulo Medical Journal
CONTEXT: Recurrent spontaneous abortion (RSA) has been associated with venous thrombosis in the mother. Acquired and inherited thrombophilia factors are possible causes.
Egle Couto, Ricardo Barini, Renata Zaccaria, Joyce Maria Annicchino-Bizzacchi, Renato Passini Junior, Belmiro Gonçalves Pereira, José Carlos Gama da Silva, João Luiz Pinto e Silva   +7 more
doaj   +1 more source

Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast [PDF]

, 2022
Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition
Aiba, Hirofumi, Matsumoto, Takuma, Mochida, Takahiro, Ohtsuka, Hokuto, Shibuya, Masatoshi, Shimasaki, Takafumi, Yamamoto, Yoshihiko   +6 more
core   +1 more source

Methylenetetrahydrofolate reductase modulates methyl metabolism and lignin monomer methylation in maize

Journal of Experimental Botany, 2018
The brown midrib2 (bm2) mutant of maize, which has a modified lignin composition, contains a mutation in the methylenetetrahydrofolate reductase (MTHFR) gene.
Zhenying Wu, H. Ren, Wangdan Xiong, S. Roje, Yuchen Liu, Kunlong Su, C. Fu   +6 more
semanticscholar   +1 more source

Compound heterozygous mutation in MTHFR gene lead to chronic cerebral venous thrombosis: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To report one case of chronic cerebral venous thrombosis (CVT) caused by compound heterozygous mutation in MTHFR gene, and to investigate the association between compound heterozygous mutation in MTHFR gene and chronic CVT as well as its ...
YU Xuan-yue, LIU Ke-xin, FAN Tie-ping, LI Shu-min, LIANG Xin-tian, LIU Yi   +5 more
doaj   +1 more source

Association Of Anticardiolipin Antibody And C677t In Methylenetetrahydrofolate Reductase Mutation In Women With Recurrent Spontaneous Abortions: A New Path To Thrombophilia? [PDF]

, 2015
Recurrent spontaneous abortion (RSA) has been associated with venous thrombosis in the mother. Acquired and inherited thrombophilia factors are possible causes.
Annicchino-Bizzacchi, Joyce Maria, Barini, Ricardo, Couto, Egle, Passini Junior, Renato, Pereira, Belmiro Gonçalves, Pinto e Silva, João Luiz, Silva, José Carlos Gama da, Zaccaria, Renata   +7 more
core