Results 11 to 20 of about 160 (141)

Mutagenic potency of MMS-induced 1meA/3meC lesions in E. coli. [PDF]

, 2009
The mutagenic activity of MMS in E. coli depends on the susceptibility of DNA bases to methylation and their repair by cellular defense systems. Among the lesions in methylated DNA is 1meA/3meC, which is recently recognized as being mutagenic.
Janion, Celina, Jadwiga Nieminuszczy, Sikora, Anna, Joanna Krwawicz, Mielecki, Damian, Wrzesiński, Michał, MichaÅ WrzesinÌski, Celina Janion, Krwawicz, Joanna, Grzesiuk, Elzbieta, Anna Sikora, ElzÌbieta Grzesiuk, Nieminuszczy, Jadwiga, Damian Mielecki, Aleksandra Chojnacka, Chojnacka, Aleksandra   +15 more
core   +1 more source

Lethal and mutagenic properties of MMS-generated DNA lesions in Escherichia coli cells deficient in BER and AlkB-directed DNA repair. [PDF]

, 2010
Methylmethane sulphonate (MMS), an S(N)2-type alkylating agent, generates DNA methylated bases exhibiting cytotoxic and mutagenic properties. Such damaged bases can be removed by a system of base excision repair (BER) and by oxidative DNA demethylation ...
Sikora, Anna, Grzesiuk, Elzbieta, A. Sikora, J. Nieminuszczy, Mielecki, Damian, D. Mielecki, A. Chojnacka, Nieminuszczy, Jadwiga, Wrzesiński, Michał, M. Wrzesinski, E. Grzesiuk, Chojnacka, Aleksandra   +11 more
core   +1 more source

Synthesis of Dihydro-and Tetrahydro-1, 2, 4, 5-tetrazines from the Reaction of Nitrilimines with 1-Substituted-1-methylhydrazine

, 2003
The reaction of nitrilimines (2) with 1-substituted-1-methylhydrazines (3–6) led to the formation of the respective amidrazones (7) when R = CH3, Ph, and to the acyclic adducts (8,9) when R = CHO and COCH3. The acyclic adducts underwent thermal oxidative
El-Sawi, Emtithal A, Dalloul, Hany M., Awadallah, Adel M., Ferwanah, Abdel-Rahman S.   +3 more
core   +1 more source

Synthetic Strategies to Access Fluorinated Azoles

European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.
This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber, Mario Djugovski, Tzu‐Yu Huang, Sweta Adhikari, Sudeshna Roy   +4 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Sequential Optimization Approach Toward an Azapeptide‐Based SARS‐CoV‐2 Main Protease Inhibitor

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
A series of small‐molecule azapeptides with various cysteine‐reactive electrophilic groups was designed, synthesized, and investigated for Mpro inhibition. Particularly suitable warheads were identified, and their linkage to a structurally expanded peptidomimetic scaffold afforded the potent lead compound 12, with kinac/Ki = 78,900 M–1s–1 and an ...
Rabea Voget, Victoria Steiger, Julian Breidenbach, Katharina Sylvester, Christin Müller‐Ruttloff, Chun‐Chiao Yang, John Ziebuhr, Norbert Sträter, Christa E. Müller, Michael Gütschow   +9 more
wiley   +1 more source

UV Absorption Cross Sections, Laser Photodissociation Product Quantum Yields, and Reactions of H Atoms with Methylhydrazines at 298 K

, 2016
The gas-phase photochemistry of the diamines monomethylhydrazine (CH3NHNH2) and unsymmetrical dimethylhydrazine ((CH3)2NNH2) has been studied in the ultraviolet (UV) at 298 K.
Ghanshyam L. Vaghjiani (1277073)
core   +1 more source

Heterobimetallic Pd‐Ru Catalysts for the Synthesis of Functionalized Polynorbornenes via Reductive Heck/ROMP Reactions

Applied Organometallic Chemistry, Volume 39, Issue 11, November 2025.
Monometallic and heterobimetallic Ru‐PdL complexes were synthesized and fully characterized. Their electrochemical properties were investigated by cyclic voltammetry. The Ru‐PdL complexes catalyzed the hydroarylation of NBD and the ROMP of Ph‐NBE. One complex catalyzed both reactions via tandem catalysis in one pot, converting NBD to poly (Ph‐NBE ...
Thais R. Cruz, Juliana I. P. Maia, Pedro I. S. Maia, Antonio E. H. Machado, Beatriz E. Goi, Lionel Delaude, Valdemiro P. Carvalho‐Jr   +6 more
wiley   +1 more source

Synthesis of Pyrazolidin‐3‐one Derivatives Bearing Trifluoromethyl Group via Cascade Michael/Intramolecular Transamidation Reactions

Asian Journal of Organic Chemistry, Volume 14, Issue 5, May 2025.
The cascade Michael/intramolecular transamidation reactions of 3‐phenacylidene‐2‐indolinone derivatives bearing a trifluoromethyl group as a novel Michael acceptor with hydrazines yielded the corresponding pyrazolidin‐3‐one derivatives in good to high yields with excellent diastereoselectivity.
Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura   +4 more
wiley   +1 more source

NorA Efflux Pump Inhibitors: Expanding SAR Knowledge of Pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐Dioxide Derivatives

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
The pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐dioxide class was investigated with the aim of enlarging the array of Staphylococcus aureus NorA efflux pump inhibitors. The ethidium bromide efflux assay was used as a first indication of NorA inhibition; then, the ability of compounds to synergize with ciprofloxacin (CPX) against both wild‐type and resistant ...
Giada Cernicchi, Alessandra Di Gregorio, Tommaso Felicetti, Elisa Rampacci, Giulia Casari, Tatiana Armeni, Brenda Romaldi, Ermelinda Zefaj, Fabrizio Passamonti, Serena Massari, Giuseppe Manfroni, Maria Letizia Barreca, Oriana Tabarrini, Carla Vignaroli, Stefano Sabatini   +14 more
wiley   +1 more source