Results 81 to 90 of about 76,676 (194)

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

, 2021
Rapamycin is a macrocyclic polyketide with immunosuppressive, antifungal, and anticancer activity produced by Streptomyces hygroscopicus ATCC 29253.
윤여준
core   +1 more source

Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes.

PLoS ONE, 2015
The branched chain amino acids (BCAA) valine, leucine and isoleucine have been implicated in a number of diseases including obesity, insulin resistance, and type 2 diabetes mellitus, although the mechanisms are still poorly understood.
Scott B Crown, Nicholas Marze, Maciek R Antoniewicz   +2 more
doaj   +1 more source

The purification and characterization of methylmalonyl CoA mutase from bovine brain

, 1974
Methylmalonyl CoA mutase has been purified over 2300-fold from bovine brain using fractional precipitation, ion exchange resins, and gel filtration procedures. The crude extract had an equal mixture of mutase in the halo- and apoenzyme form.
Martin, Damon
core  

Insights into the kinetics and reaction mechanism of B(12)-dependent methylmalonyl-CoA mutase

, 2003
B12-dependent methylmalonyl-CoA mutase catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA in the degradation of odd-chain fatty acids, branched-chain amino acids and cholesterol to energetically useful metabolites.
Vlasie, Monica Diana
core  

Inherited Methylmalonyl CoA Mutase Apoenzyme Deficiency in Human Fibroblasts EVIDENCE FOR ALLELIC HETEROGENEITY, GENETIC COMPOUNDS, AND CODOMINANT EXPRESSION

, 2020
A B S T R A C T We have measured and characterized methylmalonyl coenzyme A (CoA) mutase activity in extracts of cultured human fibroblasts from 23 patients with inherited deficiency ofthe mutase apoenzyme and from eight obligate heterozygotes for this ...

core  

Successful Pregnancy Management of a Woman With Severe Methylmalonic Acidemia

JIMD Reports
Isolated methylmalonic acidemia (MMA) is a rare, genetically heterogeneous group of metabolic disorders resulting from a deficiency of the enzyme methylmalonyl‐CoA mutase (MMUT), defects in the metabolism of its cofactor, adenosylcobalamin, or deficiency
M. Woidy, K. Tsiakas, M. Mahmud, G. Eich, S. Loos, J. Lisfeld, S. Schultz, A. C. Tallarek, K. Hecher, T. B. Huber, A. C. Muntau, G. Gramer   +11 more
doaj   +1 more source

C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development

Cell Reports, 2018
Summary: Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate.
Huimin Na, Olga Ponomarova, Gabrielle E. Giese, Albertha J.M. Walhout   +3 more
doaj   +1 more source

Mapping of the l-methylmalonyl-CoA mutase gene to mouse chromosome 17

Genomics, 1990
In humans, methylmalonyl acidemia is caused by a deficiency of L-methylmalonyl-CoA mutase (MUT) controlled by a gene that has been mapped to chromosome 6. The mouse homolog of this gene has now been mapped to mouse chromosome 17. Recombinant inbred and congenic strains place the mouse Mut locus 1.06 cM distal to H-2, between Pgk-2 and Ce-2.
J, Sertić, V, Vincek, F D, Ledley, F, Figueroa, J, Klein   +4 more
openaire   +2 more sources

Characterization and use of methylmalonyl-CoA mutase activity in Corynebacterium glutamicum

, 2009
Corynebacterium glutamicum has a very high capacity for the production of metabolites derived from central metabolism in which the citric acid cycle occupies a key position for the delivery of precursors for biosynthetic purposes.
LINDLEY, Nicholas David, BOTELLA, Laure
core  

Solvent Polarity Effects and Limited Acid Catalysis in Rearrangements of Model Radicals for the Methylmalonyl-CoA Mutase- and Isobutyryl-CoA Mutase-Catalyzed Isomerization Reactions

, 2016
The kinetics of reactions of models for the intermediate radicals formed in the methylmalonyl-CoA mutase- and isobutyryl-CoA mutase-catalyzed rearrangements were studied by laser flash photolysis methods.
Pierre Daublain (1625986), Andriy Kuznetsov (2740414), John H. Horner (2348140), Martin Newcomb (2297455)   +3 more
core   +1 more source