Results 71 to 80 of about 76,676 (194)

Methanol Metabolism in the Cytochrome and Menaquinone‐Containing Acetogen Moorella thermoacetica

Environmental Microbiology, Volume 28, Issue 7, July 2026.
The thermophilic acetogenic bacterium Moorella thermoacetica is a promising platform organism to convert C1 compounds to valuable products. Gaseous C1 substrates are technically difficult to use for fermentation in an industrial scale, but methanol, which can be produced chemically from carbon dioxide, is a suitable alternative.
Florian P. Rosenbaum, Anja Poehlein, Rolf Daniel, Volker Müller   +3 more
wiley   +1 more source

A homozygous nonsense mutation in the methylmalonyl-CoA epimerase gene (MCEE) results in mild methylmalonic aciduria

, 2006
Methylmalonic aciduria (MMA-uria) is an autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine, and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis,
Abeling, NGGM, Waterham, H. R., Bikker, H., Duran, M., Abeling, N. G. G. M., Rosenblatt, D. S., Wanders, RJA, Poll-The, BT, Waterham, HR, Kleijer, WJ (Wim), Rosenblatt, DS, Bikker, H, Bakker, HD, Kleijer, W. J., Bakker, H. D., Wanders, R. J. A., Poll-The, B. T., Duran, M (Mercedes)   +17 more
core   +1 more source

Metabolic design considerations for recycling of respiratory CO2 in leaves

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Net carbon gain in plants is significantly reduced by the loss of assimilated carbon due to respiration and other metabolism in heterotrophic tissues. Avoiding this loss is difficult due to the essential nature of the metabolic processes involved but it could be possible to engineer metabolism to reuse the generated CO2.
Corinna Hartinger, Edward N. Smith, Lee J. Sweetlove   +2 more
wiley   +1 more source

methylmalonyl CoA mutase reaction

, 1997
In the metabolism of propionyl CoA L-methylmalonyl CoA is converted to succinate by methylmalonyl CoA mutase.

core  

Diagram of pBAC_MMA showing the size of the insert and the relation of the methylmalonyl-CoA mutase locus to flanking upstream and downstream sequence (A).

, 2013
(B) Two intact genes are contained within pBAC_MMA. The methylmalonyl-CoA mutase and centromere protein Q (Cenpq) loci are divergently transcribed and share a putative 200 bp CpG island.
Leonie R. Wood (307547), Heidi L. Peters (307548), James J. Pitt (307546), Natasha J. Hamilton (316752), Joseph P. Sarsero (214516), Nicole E. Buck (307544)   +5 more
core   +1 more source

Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase [PDF]

Nature Chemical Biology, 2008
Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesis of adenosylcobalamin, is shown to be involved in delivery of the cofactor to MCM.
openaire   +1 more source

Clinical Outcomes and Correlation With Biochemical Control in Hydroxocobalamin‐Treated Patients With Early‐Onset Cobalamin C Disease

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Cobalamin C (cblC) disease is the most common disorder of Vitamin B12 activation. The early‐onset form presents within the first few months of life, with some patients identified through newborn screening (NBS). However, despite early detection and optimal treatment, patient outcomes remain poor, with intellectual impairment and progressive ...
Arthavan Selvanathan, Ashley Hertzog, Jacqui Russell, Rosie Junek, Carolyn Ellaway, Kate Lichkus, Adviye Ayper Tolun, Kaustuv Bhattacharya   +7 more
wiley   +1 more source

Fatal Case Report of Methylmalonic Acidemia: Reflections on Organic Acidemias in Colombia [PDF]

Journal of Inborn Errors of Metabolism and Screening
Methylmalonic acidemia (MMA) is a rare hereditary metabolic disorder caused by defects in the methylmalonyl-CoA mutase pathway, leading to toxic metabolite accumulation and severe multi-organ complications.
Ana María Zarante Bahamon, Juan Sebastián Rincón Redondo, Sandra Navarro Marroquin, Dairo Jesús Cera Cabarcas, Juan Carlos Prieto Rivera   +4 more
doaj   +1 more source

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

Computational Insights into the Mechanism of Radical Generation in B₁₂-Dependent Methylmalonyl-CoA Mutase

, 2016
ONIOM calculations have provided novel insights into the mechanism of homolytic Co−C5‘ bond cleavage in the 5‘-deoxyadenosylcobalamin cofactor catalyzed by methylmalonyl-CoA mutase.
Ilja V. Khavrutskii (138382), Djamaladdin G. Musaev (1391992), Ruma Banerjee (45954), Piotr Paneth (808019), Renata A. Kwiecien (2653012), Keiji Morokuma (1247166)   +5 more
core   +1 more source