Results 51 to 60 of about 80,661 (193)

Isolation and Expression of a cDNA Encoding Methylmalonic Aciduria Type A Protein from Euglena gracilis Z

Metabolites, 2013
In animals, cobalamin (Cbl) is a cofactor for methionine synthase and methylmalonyl-CoA mutase (MCM), which utilizes methylcobalamin and 5′-deoxyadenosylcobalamin (AdoCbl), respectively.
Fumio Watanabe, Satoshi Kasagaki, Ryota Takamatsu, Yukinori Yabuta   +3 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

Revisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy [PDF]

J Inherit Metab Dis
ABSTRACT Selective autophagy is increasingly recognized as a fundamental quality‐control mechanism that complements bulk autophagy by enabling the targeted degradation of specific intracellular cargos, including mitochondria, endoplasmic reticulum (ER), lipid droplets, glycogen, peroxisomes, ferritin, ribosomes, and protein aggregates.
Maddaluno M, Cinque L, Cetrangolo V, De Leonibus C.   +3 more
europepmc   +2 more sources

Insertional inactivation of methylmalonyl coenzyme A (CoA) mutase and isobutyryl-CoA mutase genes in Streptomyces cinnamonensis: influence on polyketide antibiotic biosynthesis.

, 1999
The coenzyme B(12)-dependent isobutyryl coenzyme A (CoA) mutase (ICM) and methylmalonyl-CoA mutase (MCM) catalyze the isomerization of n-butyryl-CoA to isobutyryl-CoA and of methylmalonyl-CoA to succinyl-CoA, respectively. The influence that both mutases
Ratnatilleke A, Vrijbloed JW, Zerbe-Burkhardt K, Grubelnik-Leiser A, Robinson JA   +4 more
core   +1 more source

Diagram of pBAC_MMA showing the size of the insert and the relation of the methylmalonyl-CoA mutase locus to flanking upstream and downstream sequence (A).

, 2013
(B) Two intact genes are contained within pBAC_MMA. The methylmalonyl-CoA mutase and centromere protein Q (Cenpq) loci are divergently transcribed and share a putative 200 bp CpG island.
Leonie R. Wood (307547), Heidi L. Peters (307548), James J. Pitt (307546), Natasha J. Hamilton (316752), Joseph P. Sarsero (214516), Nicole E. Buck (307544)   +5 more
core   +1 more source

Specific activity of enzymes of the C₂ specific steps of the ethylmalonyl-CoA pathway and their regulation.

, 2013
Enzymes: Pcc, propionyl-CoA carboxylase; Epi, ethylmalonyl-CoA/methylmalonyl-CoA epimerase; Mcm, methylmalonyl-CoA mutase; Mcl2, malyl-CoA thioesterase. The y axis is in nmol min−1 mg−1 protein.
Georg Fuchs (361294), Hana Šmejkalová (361292), Tobias J. Erb (361293)   +2 more
core   +1 more source

Cobamide Scavenging and Import via a Multiprotein Extracellular Relay in Bacteroides thetaiotaomicron

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Bacteroides thetaiotaomicron competes with gut microbes and the host for a limited cobamide pool. To meet this demand, it deploys surface associated lipoproteins (BtuJ, BtuH, BtuK, BtuG), three BtuB paralogs, and extracellular vesicles that extend cobamide capture beyond the cell surface. This review examines the structural and mechanistic evidence for
Alexander Drake, Romila Mascarenhas
wiley   +1 more source

Fully automated assay for cobalamin-dependent methylmalonyl CoA mutase

Clinical Chemistry, 1995
Abstract We constructed a fully automated assay for the cobalamin-dependent enzyme methylmalonyl coenzyme A (CoA) mutase. The assay involves preincubation of the enzyme with adenosylcobalamin, incubation with substrate, termination of the reaction by adding trichloroacetic acid, filtration to remove precipitated protein, and finally ...
B, Riedel, P M, Ueland, A M, Svardal
openaire   +2 more sources

Energetic and stereochemical effects of the protein environment on substrate: A theoretical study of methylmalonyl-CoA mutase

, 2003
QM/MM methods were used to study the isomerization step from (2R)-methylmalonyl-CoA to succinyl-CoA. A pathway via a “fragmentation−recombination” mechanism is ruled out on energetic grounds.
Grant, Guy
core   +1 more source

Seasonal Effect of a Small Hydropower Plant on Benthic Biofilm Microbial Community Structure and Predicted Functional Potential

Ecology and Evolution, Volume 16, Issue 9, September 2026.
Biofilm microbial composition varies significantly; diversity is higher in spring and autumn. The dewatered reach shows the broadest niche and dominant stochastic assembly. Seasonal assembly shift: deterministic in summer, stochastic in winter. Nutrient cycling genes vary more among sites than seasons under SHP influence.
Huimin Gao, Sangar Khan, Xinxin Qi, Zongwei Lin, Guohao Liu, Yuanyuan Lv, Min Zhang, Zhijun Xia, Naicheng Wu   +8 more
wiley   +1 more source