Results 51 to 60 of about 76,676 (194)
Advanced Science, Volume 13, Issue 46, 17 August 2026.ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu +15 more
wiley +1 more source
Stereochemistry of the methylmalonyl-CoA decarboxylation reaction [PDF]
, 1987 The steric course of the decarboxylation of (S)-methylmalonyl-CoA to propionyl-CoA, catalyzed by the biotin-dependent sodium pump methylmalonyl-CoA decarboxylase of Veillonella alcalescens was determined.
Hoffmann, Artur, Dimroth, Peter
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Central nervous system-targeted adeno-associated virus gene therapy in methylmalonic acidemia
Molecular Therapy: Methods & Clinical Development, 2021 Methylmalonic acidemia (MMA) is a severe metabolic disorder most commonly caused by a mutation in the methylmalonyl-CoA mutase (MMUT) gene. Patients with MMA experience multisystemic disease manifestations and remain at risk for neurological disease ...
Francis J. May +4 more
doaj +1 more source
Imerslund‐Gräsbeck Syndrome Caused by Compound Heterozygous Mutations in the AMN Gene: A Case Report
Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT The 7‐year‐old girl had recurrent anemia for 6 years, showing large cell anemia. The parent‐derived AMN double heterozygous mutation was detected to confirm the diagnosis of IGS. The hemogram was normal after intramuscular injection of vitamin B12, and there were no other complications.
Cheng Chen +8 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 4, August 2026.This paper aims to address critical gaps in the literature by providing a comprehensive, integrative synthesis of recent advances in Streptomyces strain improvement, with a particular focus on optimizing secondary metabolite production through a multidisciplinary approach.
Anum Goraya +5 more
wiley +1 more source
, 2008 Coenzyme B(12)-dependent mutases are radical enzymes that catalyze reversible carbon skeleton rearrangement reactions. Here we describe Rhodobacter sphaeroides ethylmalonyl-CoA mutase (Ecm), a novel member of the family of coenzyme B(12)-dependent acyl ...
Retey, J., Alber, B., Fuchs, G., Erb, T.
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A protein having similarity with methylmalonyl-CoA mutase is required for the assimilation of methanol and ethanol by Methylobacterium extorquens AM1 [PDF]
, 1996 A 4.0 kb region of Methylobacterium extorquens AM1 DNA which complements three mutants unable to convert acetyl-CoA to glyoxylate (and therefore defective in the assimilation of methanol and ethanol) has been isolated and sequenced.
Smith, Loraine M. +4 more
core +2 more sources
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Hypoxia results in fragmented mitochondria. Whether this fragmentation promotes or prevents cell death is unresolved. Caenorhabditis elegans mutants defective in mitochondrial fission and fusion coupled with a hypoxia resistant Raptor mutant demonstrated that hypoxia‐induced mitochondrial fragmentation occurs without an intact fission machinery and ...
Julien Goldstick +4 more
wiley +1 more source
, 2002 Methylmalonyl-CoA mutase is an adenosylcobalamin (AdoCbl)-dependent enzyme that catalyzes the rearrangement of methylmalonyl-CoA to succinyl-CoA. The crystal structure of this protein revealed that binding of the cofactor is accompanied by a significant ...
Vlasie, Monica +2 more
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, 1996 Differential screening of gerbil brain hippocampal cDNA libraries was used to search for genes expressed in ischemic, but not normal, brain. The methylmalonyl-CoA mutase (MCM) cDNA was highly expressed after ischemia and showed a 95% similarity to mouse ...
Purnima Narasimhan +4 more
core +1 more source