The role of B12 deficiency and methionine synthase in methionine-dependent cancer cells [PDF]
Cancer & MetabolismBackground Human cells can synthesize methionine from homocysteine and folate-coupled methyl groups via the B12-dependent enzyme methionine synthase (MTR).
Mohamed M. A. El Husseiny +1 more
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Cognitive Impairment Is Associated with AMPAR Glutamatergic Dysfunction in a Mouse Model of Neuronal Methionine Synthase Deficiency [PDF]
Cells, 2023 Impairment of one-carbon metabolism during pregnancy, either due to nutritional deficiencies in B9 or B12 vitamins or caused by specific genetic defects, is often associated with neurological defects, including cognitive dysfunction that persists even ...
Ziad Hassan +9 more
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Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence [PDF]
mBio, 2020 There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH).
Jennifer Scott +13 more
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Structural insights into cobalamin loading and reactivation of human methionine synthase [PDF]
Nature CommunicationsHuman methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in the methyl transfer from methyltetrahydrofolate to ...
Douglas S. M. Ferreira +13 more
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Methionine Synthase 2 Represses Stem Cell Maintenance of Arabidopsis thaliana in Response to Salt Stress [PDF]
PlantsSalt stress represses the growth and development of plants that mainly depend on the continual propagation and differentiation of stem cells. WUSCHEL (WUS)/WUSCHEL-RELATED HOMEOBOX (WOX) family proteins determine stem cell fate in plants under ever ...
Jiaqi Qiu +5 more
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Biological Activity of Pseudovitamin B12 on Cobalamin-Dependent Methylmalonyl-CoA Mutase and Methionine Synthase in Mammalian Cultured COS-7 Cells [PDF]
Molecules, 2020 Adenyl cobamide (commonly known as pseudovitamin B12) is synthesized by intestinal bacteria or ingested from edible cyanobacteria. The effect of pseudovitamin B12 on the activities of cobalamin-dependent enzymes in mammalian cells has not been studied ...
Tomohiro Bito +8 more
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Breed differences in the expression levels of gga-miR-222a in laying hens influenced H2S production by regulating methionine synthase genes in gut bacteria [PDF]
Microbiome, 2021 Background The microbiota in the cecum of laying hens is crucial for host digestion, metabolism, and odor gas production. The results of recent studies have suggested that host microRNAs (miRNAs) can regulate gene expression of the gut microbiota. In the
Si-Cheng Xing +8 more
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Late‐onset refractory hemolytic anemia in siblings treated for methionine synthase reductase deficiency: A rare complication possibly prevented by hydroxocobalamin dose escalation? [PDF]
JIMD ReportsMethionine synthase reductase deficiency (cblE) is a rare autosomal recessive inborn error of cobalamin metabolism caused by pathogenic variants in the methionine synthase reductase gene (MTRR).
Alexandre Nguyen +7 more
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Classical Homocystinuria Incidentally Diagnosed Following a Normal Newborn Screening Result [PDF]
International Journal of Neonatal ScreeningClassical homocystinuria (HCY) due to cystathionine beta-synthase (CBS) deficiency is included in many newborn screening programs, which traditionally use dried blood spot (DBS) methionine as the primary biomarker.
José Manuel González de Aledo-Castillo +15 more
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Reactions, 2023 The Methionine Synthase process, in principle, can take an unlimited number of turnovers in the presence of the AdoMet substrate. In the absence of this substrate, the Methionine Synthase process lasts only about 2000 turnovers.
Tudor Spataru
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