Results 11 to 20 of about 291,374 (170)
The Polymorphisms in Methylenetetrahydrofolate Reductase, Methionine Synthase, Methionine Synthase Reductase, and the Risk of Colorectal Cancer [PDF]
International Journal of Biological Sciences, 2012 Polymorphisms in genes involved in folate metabolism may modulate the risk of colorectal cancer (CRC), but data from published studies are conflicting. The current meta-analysis was performed to address a more accurate estimation.
Daijun Zhou, Qiang Mei, Han Luo, Bo Tang, Peiwu Yu
doaj +4 more sources
Four families of folate-independent methionine synthases. [PDF]
PLoS Genetics, 2021 Although most organisms synthesize methionine from homocysteine and methyl folates, some have "core" methionine synthases that lack folate-binding domains and use other methyl donors.
Morgan N Price +2 more
doaj +7 more sources
Human B12-dependent enzymes: Methionine synthase and Methylmalonyl-CoA mutase. [PDF]
Methods Enzymol, 2022 Humans have only two known cobalamin or B(12)-dependent enzymes: cytoplasmic methionine synthase and mitochondrial methylmalonyl-CoA mutase. A complex intracellular B(12) trafficking pathway, comprising a multitude of chaperones, process and deliver ...
Mascarenhas R +3 more
europepmc +2 more sources
Methionine synthase supports tumour tetrahydrofolate pools. [PDF]
Nat Metab, 2021 Mammalian cells require activated folates to generate nucleotides for growth and division. The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR).
Ghergurovich JM +6 more
europepmc +3 more sources
In vitro inactivation of mammalian methionine synthase by nitric oxide
, 1996 The research described here provides one mechanism of uniting current effects of nitric oxide (NO) with the elevated levels of homocysteine detected in patients with cardiovascular and other disease.
Gibbons, W. A. +4 more
core +8 more sources
Leukemia Research, 2008 We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM).
Carmen S P, Lima +7 more
core +4 more sources
A study into the cobalamin-dependent methionine synthase reactivation mechanism in corynebacterium glutamicum [PDF]
, 2009 PhDMethionine is one of the seven essential amino-acids for humans and is also used in feed supplements, predominantly for poultry and felines. Thus there is commercial interest in producing this nutrient. The final step in the biological synthesis of
Burton-Smith, Raymond Nathaniel
core +4 more sources
Human methionine synthase reductase is a molecular chaperone for human methionine synthase [PDF]
Proceedings of the National Academy of Sciences, 2006 Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins. In this study, recombinant human MS (hMS) and MSR (hMSR) were expressed in baculovirus-infected insect cells and purified to homogeneity.
Kazuhiro, Yamada +3 more
openaire +2 more sources
Cobalamin‐dependent methionine synthase [PDF]
The FASEB Journal, 1990 Cobalamin‐dependent methionine synthase catalyzes the transfer of a methyl group from N 5 ‐methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine. Insufficient availability of cobalamin, or inhibition of methionine synthase by exposure to nitrous oxide, leads to ...
Banerjee, Ruma V., Matthews, Rowena G.
openaire +3 more sources
Plasma Methionine and Clinical Severity in Nitrous Oxide Consumption
Toxics, 2022 In the last few years, there has been an increase in the recreational use of nitrous oxide (N2O), which can lead to neurological symptoms such as sensory or motor disorders.
Emeline Gernez +5 more
doaj +1 more source