Results 31 to 40 of about 291,374 (170)

Interactions between vitamin B2, the MTRR rs1801394 and MTR rs1805087 genetic polymorphisms, and colorectal cancer risk in a Korean population [PDF]

Epidemiology and Health
OBJECTIVES We explored whether the association between vitamin B2 and colorectal cancer (CRC) risk could be modified by the MTRR rs1801394 and MTR rs1805087 genetic polymorphisms and examined whether the interaction effects are sex-specific.
Madhawa Gunathilake, Minji Kim, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim   +7 more
doaj   +1 more source

C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium

Biomolecules, 2020
Many pharmacologically important peptides are bacterial or fungal in origin and contain nonproteinogenic amino acid (NPA) building blocks. Recently, it was reported that, in bacteria, a cyclopropane-containing NPA 1-aminocyclopropanecarboxylic acid (ACC)
Chitose Maruyama, Yukiko Chinone, Shusuke Sato, Fumitaka Kudo, Kosuke Ohsawa, Junya Kubota, Junko Hashimoto, Ikuko Kozone, Takayuki Doi, Kazuo Shin-ya, Tadashi Eguchi, Yoshimitsu Hamano   +11 more
doaj   +1 more source

Potential mechanism for hyperhomocysteinemia in Greyhound dogs

Journal of Veterinary Internal Medicine, 2023
Background Greyhounds have been reported to have hyperhomocysteinemia (HHC), but the underlying mechanisms and clinical implications are unclear. Hypothesis Our primary aim was to assess serum concentrations of homocysteine (HCy) and related analytes in ...
Kelsey L. Johnson, Torrey Tiedeman, Hannah Peterson, Joerg M. Steiner, Lauren A. Trepanier   +4 more
doaj   +1 more source

Vitamin B12 Supplementation Improves Oocyte Development by Modulating Mitochondria and Yolk Protein in a Caffeine-Ingested Caenorhabditis elegans Model

Antioxidants, 2023
Vitamin B12 is an essential cofactor involved in the function of two enzymes: cytosolic methionine synthase and mitochondrial methylmalonic-CoA mutase. In our previous studies, caffeine (1,3,7-trimethylxanthine), the most popular bioactivator, was shown ...
Hyemin Min, Mijin Lee, Sangwon Kang, Yhong-Hee Shim   +3 more
doaj   +1 more source

Role of folate metabolizing genes and homocysteine in mothers of Down syndrome children

Tzu Chi Medical Journal, 2022
Objectives: Folates are essential nutrients required for the synthesis of DNA/RNA in cell division and segregation. Folates are reduced and methylated in the liver with the help of enzymes such as methylenetetrahydrofolate reductase (MTHFR), MTR MTRR ...
Amandeep Kaur, Anupam Kaur
doaj   +1 more source

Conversion of Homocysteine to Methionine by Methionine Synthase: A Density Functional Study

Journal of the American Chemical Society, 2003
This communication reports a theoretical study of the conversion of homocysteine to methionine by methionine synthase. The reaction pathway is based on density functional calculations with large basis sets, including thermodynamic, relativistic, and solvent effects.
Jensen, Kasper, Ryde, Ulf
openaire   +2 more sources

Insights into the reactivation of cobalamin-dependent methionine synthase [PDF]

Proceedings of the National Academy of Sciences, 2009
Cobalamin-dependent methionine synthase (MetH) is a modular protein that catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine to produce methionine and tetrahydrofolate. The cobalamin cofactor, which serves as both acceptor and donor of the methyl group, is oxidized once every ≈2,000 catalytic cycles
Markos, Koutmos, Supratim, Datta, Katherine A, Pattridge, Janet L, Smith, Rowena G, Matthews   +4 more
openaire   +2 more sources

Effect of methionine synthase A2756G and methionine synthase reductase A66G gene polymorphisms in male infertility

Urology Research and Practice, 2019
Objective: In this study, we investigated whether methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms were related with infertility.
Ali Şahin Küçükaslan, Raşit Altıntaş, Vildan Bozok Çetintaş, Aslı Tetik, Murat Ulukuş, Bülent Semerci, Zuhal Eroğlu   +6 more
doaj   +2 more sources

Short Methionine Synthases

, 2020
Abstract Although most organisms synthesize methionine from homocysteine and 5-methyltetrahydrofolate, we propose that many bacteria and archaea use alternative enzymes that rely on other methyl donors. These methionine synthases are homologous to MetE, which uses 5-methyltetrahydrofolate, but they lack the N-terminal folate-binding domain of MetE. We
Price, Morgan N., Arkin, Adam P.
openaire   +1 more source

Activation of Methyltetrahydrofolate by Cobalamin-Independent Methionine Synthase [PDF]

Biochemistry, 2006
Cobalamin-independent methionine synthase (MetE) catalyzes the final step of de novo methionine synthesis using the triglutamate derivative of methyltetrahydrofolate (CH(3)-H(4)PteGlu(3)) as methyl donor and homocysteine (Hcy) as methyl acceptor. This reaction is challenging because at physiological pH the Hcy thiol is not a strong nucleophile and CH(3)
Rebecca E, Taurog, Rowena G, Matthews
openaire   +2 more sources