Results 21 to 30 of about 291,374 (170)

Identification and characterization of a bacterial core methionine synthase. [PDF]

Sci Rep, 2020
Abstract Methionine synthases are essential enzymes for amino acid and methyl group metabolism in all domains of life. Here, we describe a putatively anciently derived type of methionine synthase yet unknown in bacteria, here referred to as core-MetE.
Deobald D, Hanna R, Shahryari S, Layer G, Adrian L.   +4 more
europepmc   +5 more sources

An infant with an extremely rare cobalamin disorder: Methionine synthase deficiency and importance of early diagnosis and treatment

The Turkish Journal of Pediatrics, 2019
Functional methionine synthase deficiency can be separated into two classes, cobalamin (Cbl) deficiency type E (CblE) and type G (CblG), which are the result of mutations that affect methionine synthase reductase or methionine synthase, respectively ...
Çiğdem Seher Kasapkara, Ebru Yılmaz-Keskin, Ferda Özbay-Hoşnut, Meltem Akçaboy, Emine Polat, Asburçe Olgaç, Pelin Zorlu   +6 more
doaj   +1 more source

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. [PDF]

PLoS ONE, 2015
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood.
Tommy Pacana, Sophie Cazanave, Aurora Verdianelli, Vaishali Patel, Hae-Ki Min, Faridoddin Mirshahi, Eoin Quinlivan, Arun J Sanyal   +7 more
doaj   +1 more source

High-dose folic acid supplementation results in significant accumulation of unmetabolized homocysteine, leading to severe oxidative stress in Caenorhabditis elegans

Redox Biology, 2020
Using Caenorhabditis elegans as a model animal, we evaluated the effects of chronical supplementation with high-dose folic acid on physiological events such as life cycle and egg-laying capacity and folate metabolism.
Kyohei Koseki, Yukina Maekawa, Tomohiro Bito, Yukinori Yabuta, Fumio Watanabe   +4 more
doaj   +1 more source

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source

Methionine synthase and neural tube defects. [PDF]

Journal of Medical Genetics, 1997
Contains fulltext : 24399___.PDF (Publisher’s version ) (Open Access)
Morrison, K., Edwards, Y.H., Lynch, S.A., Burn, J., Hol, F.A., Mariman, E.C.M.   +5 more
openaire   +4 more sources

In Vitro and in Vivo Effects of Alkyl Nitrites on Methionine Synthase from Mouse Kidney and Liver

Pteridines, 1989
The effect of butyl and isoamyl nitrites on methionine synthase from mouse kidney and liver was investigated. A strong specific inhibition of the enzyme (50% at 7.3 x 10 4 M nitrites for kidney methionine synthase) was found.
Manteuffel-Cymborowska Malgorzata, Chmurzyńska Wanda, Kamińska Bożena, Sikora Ewa, Grzelakowska-Sztabert Barbara   +4 more
doaj   +1 more source

Antimalarial target vulnerability of the putative <i>Plasmodium falciparum</i> methionine synthase. [PDF]

PeerJ
Background Plasmodium falciparum possesses a cobalamin-dependent methionine synthase (MS). MS is putatively encoded by the PF3D7_1233700 gene, which is orthologous and syntenic in Plasmodium.
Leela N, Prommana P, Kamchonwongpaisan S, Taechalertpaisarn T, Shaw PJ.   +4 more
europepmc   +3 more sources

Association of maternal MTR gene polymorphism with offspring congenital heart disease: a case-control study

Zhongguo gonggong weisheng, 2022
ObjectiveTo explore the association between maternal methionine synthase (MTR) gene polymorphism and the risk of congenital heart disease (CHD) in offsprings.
Yi-huan LI, Peng HUANG, Ting-ting WANG
doaj   +1 more source

Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap

Biology Open, 2015
In addition to its role in the endogenous synthesis of cysteine, cystathionine gamma-lyase (CGL) is a major physiological source of the vasorelaxant hydrogen sulfide.
Hua Jiang, K. Joseph Hurt, Kelsey Breen, Sally P. Stabler, Robert H. Allen, David J. Orlicky, Kenneth N. Maclean   +6 more
doaj   +1 more source