Results 41 to 50 of about 291,374 (170)
Bulletin of Faculty of Pharmacy Cairo University, 2011 Aim: The enzyme methionine synthase (MetS) is linked to the cancer pathogenesis disorders such as myeloid leukemia, prostate and breast tumors. Inhibition of the biosynthesis of methionine amino acid which provides the tumor nucleic acid with one carbon ...
Hosam A. Ahmed
doaj +1 more source
Фактори експериментальної еволюції організмів, 2019 Aim. Aim of this study was to determine the role of the genome of folate metabolism in the formation of triiodothyronine in children living in areas affected by the Chernobyl nuclear power plant accident. Methods.
Yu. I. Bandazhevsky, N. F. Dubovaya
doaj +1 more source
Defects in human methionine synthase in cblG patients [PDF]
Human Molecular Genetics, 1996 Inborn errors resulting in isolated functional methionine synthase deficiency fall into two complementation groups, cblG and cblE. Using biochemical approaches we demonstrate that one cblG patient has greatly reduced levels of methionine synthase while in another, the enzyme is specifically impaired in the reductive activation cycle.
S, Gulati +6 more
openaire +2 more sources
Methionine synthase activity in autism.
, 2016 Methionine synthase activity in frontal cortex of autistic and age-matched control subjects measured either with only endogenous Cbl or with the addition of OHCbl.
Richard C. Deth (380205) +7 more
core +1 more source
Auxotrophic Selection Strategy for Improved Production of Coenzyme B12 in Escherichia coli
iScience, 2020 Summary: The production of coenzyme B12 using well-characterized microorganisms, such as Escherichia coli, has recently attracted considerable attention to meet growing demands of coenzyme B12 in various applications. In the present study, we designed an
Myung Hyun Noh +4 more
doaj +1 more source
, 2007 We observed vitamin B(12)-mediated growth inhibition of Mycobacterium tuberculosis strain CDC1551. The B(12) sensitivity was mapped to a polymorphism in metH, encoding a coenzyme B(12)-dependent methionine synthase.
Warner, DF +3 more
core +1 more source
Effect of methionine supplementation on methionine metabolism in growing cattle [PDF]
, 2002 Methionine is often the first limiting amino acid for growing cattle. This study was conducted to determine how methionine metabolism is regulated in the liver of growing steers.
Löest, C.A. +5 more
core +1 more source
Regulation of Folate Metabolizing Enzymes In Fungus Aspergillus nidulans
Pteridines, 1993 The regulation of methionine synthase. serine hydroxymethyltransferase. methylenetetrahydrofolate oxidorelluctase and dihydrofolate reductase in Aspergillus nidulans have been found to be controlled by endogenous pools methionine and homocysteine ...
Balińska Malgorzata +2 more
doaj +1 more source
Targeted Disruption of the Methionine Synthase Gene in Mice [PDF]
Molecular and Cellular Biology, 2001 Alterations in homocysteine, methionine, folate, and/or B12 homeostasis have been associated with neural tube defects, cardiovascular disease, and cancer. Methionine synthase, one of only two mammalian enzymes known to require vitamin B12 as a cofactor, lies at the intersection of these metabolic pathways. This enzyme catalyzes the transfer of a methyl
D A, Swanson +9 more
openaire +2 more sources
The inactivation of methionine synthase in isolated rat hepatocytes by sodium nitroprusside
, 1997 Methionine synthase, the enzyme that catalyses the transfer of a methyl group from 5-methyl tetrahydrofolate to homocysteine via the cofactor methylcobalamin, is one of the two established mammalian enzymes that utilise a biologically active vitamin B-12
Kenyon, Susan H. +3 more
core +5 more sources