Results 61 to 70 of about 291,374 (170)

Influence of methionine synthase on postnatal neurogenesis & ophthalmological consequences of invalidation of methionine synthase

, 2022
Inborn defects in vitamin B12 (cobalamin) metabolism including CblG pathology caused by mutations in the MTR gene encoding the methionine synthase (MS) enzyme are responsible for the development of persistent symptoms upon treatment, particularly neurological, neurocognitive, and ophthalmological symptoms.
openaire   +2 more sources

Cobamide metabolism, regulation, and adaptation in Mycobacterium tuberculosis

Journal of Bacteriology
Cobamides play a paradoxical but critical role in the biology of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. Although Mtb retains nearly all cobalamin (Cbl) biosynthetic genes and encodes multiple cobamide-requiring enzymes ...
Terry Kipkorir, Rendani D. Mbau, Digby F. Warner, Gopinath Krishnamoorthy, Atica Moosa   +4 more
doaj   +1 more source

Plasma methionine concentrations and incidence of hypermethioninemic encephalopathy during infancy in a large cohort of 36 patients with classical homocystinuria in the Republic of Ireland

JIMD Reports, 2019
Background Classical homocystinuria is an autosomal recessive disorder caused by profound cystathionine β‐synthase deficiency. Its biochemical hallmarks are high concentrations of plasma homocyst(e)ine and methionine. Clinical manifestations include lens
John Allen, Bronwyn Power, Aida Abedin, Orla Purcell, Ina Knerr, Ahmad Monavari   +5 more
doaj   +1 more source

Purification, characterisation and inhibition of methionine synthase from rat liver [PDF]

, 1995
Cobalamin-dependent methionine synthase catalyses the transfer of a methyl group from methyltetrahydrofolate to homocysteine, generating tetrahydrofolate and methionine.
Ast, Tamara
core   +1 more source

Constitutive expression of feedback-insensitive cystathionine γ-synthase increases methionine levels in soybean leaves and seeds

Journal of Integrative Agriculture, 2018
Soybean (Glycine max (L.) Merr.) is a major crop that provides plant-origin protein and oil for humans and livestock. Although the soybean vegetative tissues and seeds provide a major source of high-quality protein, they suffer from low concentration of ...
Yang YU, Wen-sheng HOU, Yael Hacham, Shi SUN, Cun-xiang WU, Ifat Matityahu, Shi-kui SONG, Rachel Amir, Tian-fu HAN   +8 more
doaj   +1 more source

Polymorphisms in genes MTHFR, MTR and MTRR are not risk factors for cleft lip/palate in South Brazil

Brazilian Journal of Medical and Biological Research, 2007
Non-syndromic cleft lip and palate (CL/P) occurs due to interaction between genetic and environmental factors. Abnormalities in homocysteine metabolism may play a role in its etiology due to polymorphisms in genes involved in this pathway. Because of the
A.P.C. Brandalize, E. Bandinelli, J.B. Borba, T.M. Félix, I. Roisenberg, L. Schüler-Faccini   +5 more
doaj  

Systems genetics identifies methionine as a high risk factor for Alzheimer's disease

Frontiers in Neuroscience
As a dietary strategy, methionine restriction has been reported to promote longevity and regulate metabolic disorders. However, the role and possible regulatory mechanisms underlying methionine in neurodegenerative diseases such as Alzheimer's disease ...
Congmin Wang, Yu Hei, Yu Liu, Yu Liu, Akhilesh Kumar Bajpai, Yuhe Li, Yawen Guan, Fuyi Xu, Fuyi Xu, Cuifang Yao, Cuifang Yao   +10 more
doaj   +1 more source

INHIBITION OF FETAL METHIONINE SYNTHASE BY NITROUS OXIDE

British Journal of Anaesthesia, 1984
The activity of the enzyme methionine synthase in fetal and maternal liver was investigated before and after exposure to nitrous oxide. Timed-pregnant rats on day 19 of gestation were exposed to either 10% or 50% nitrous oxide for various times up to 240 min.
J M, Baden, M, Serra, R I, Mazze
openaire   +2 more sources

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations [PDF]

, 2004
CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms of life. Although thought to be regulatory, their exact functions have been unknown.
John W. Scott, D. Grahame Hardie, Norman, D G, Miliea Anis, Scullion, Gillian A., Stewart, Greg, Scullion, Gillian A, Scott, J.W, Green, Kevin A, Simon A. Hawley, David G. Norman, Hawley, Simon A., Norman, David G., Gillian A. Scullion, Kevin A. Green, Scott, John W., Anis, Miliea, Green, Kevin A., Hardie, D. Grahame, Hawley, Simon A, Greg Stewart   +20 more
core   +1 more source