Results 71 to 80 of about 291,374 (170)

Posttranscriptional Regulation of Mammalian Methionine Synthase by B12

Biochemical and Biophysical Research Communications, 1999
Methionine synthase is one of two key enzymes involved in the removal of the metabolite, homocysteine. Elevated homocysteine levels constitute a risk factor for cardiovascular diseases and for neural tube defects. In cell culture, the activity of methionine synthase is enhanced several-fold by supplementation with its cofactor, B12.
Gulati, Sumedha, Brody, Lawrence C., Banerjee, Ruma V.   +2 more
openaire   +3 more sources

Cobalt-sulfur coordination chemistry drives B\u3csub\u3e12\u3c/sub\u3e loading onto methionine synthase [PDF]

, 2023
Cobalt-sulfur (Co-S) coordination is labile to both oxidation and reduction chemistry and is rarely seen in Nature. Cobalamin (or vitamin B12) is an essential cobalt-containing organometallic cofactor in mammals, and is escorted via an intricate network ...
Banerjee, Ruma, Mascarenhas, Romila, Seravalli, Javier, Li, Zhu, Ruetz, Markus, An, Sojin, Guha, Arkajit   +6 more
core  

Biochemical and genetic characterization of mammalian methionine synthase

, 1998
Mammalian methionine synthase (5-methyl-homocysteine methyltransferase; EC 2.1.1.13) is a cobalamin dependent enzyme that catalyzes the transfer of a methyl group from methyltetrahydrofolate to homocysteine, and generates methionine and tetrahydrofolate.
Gulati, Sumedha
core   +1 more source

Biochemical studies of human methionine synthase reductase

, 2003
Methionine synthase is one of the major enzymes that metabolizes homocysteine and catalyzes the transfer of a methyl group from the substrate, methyltetrahydrofolate to the cobalamin cofactor and subsequently, to the second substrate, homocysteine to ...
Olteanu, Horatiu
core  

Differences in the Efficiency of Reductive Activation of Methionine Synthase and Exogenous Electron Acceptors between the Common Polymorphic Variants of Human Methionine Synthase Reductase^†

, 2016
Methionine synthase reductase (MSR) catalyzes the conversion of the inactive form of human methionine synthase to the active state of the enzyme. This reaction is of paramount physiological importance since methionine synthase is an essential enzyme that
Troy Munson (2946864), Ruma Banerjee (45954), Horatiu Olteanu (2946867)   +2 more
core   +1 more source

Identification of metE as a second target of the sRNA scr5239 in Streptomyces coelicolor.

PLoS ONE, 2015
While transcriptional regulation of the primary and secondary metabolism of the model organism Streptomyces coelicolor is well studied, little is still known about the role small noncoding RNAs (sRNAs) play in regulating gene expression in this organism.
Michael-Paul Vockenhuber, Nona Heueis, Beatrix Suess   +2 more
doaj   +1 more source

Role of heat-shock proteins and cobalamine in maintaining methionine synthase activity [PDF]

, 2012
Atheromatous plaque is one of the most common cardiovascular-related diseases. Reports show a connection between its development and the levels of homocysteine.
Banasiuk, Rafał, Grabowski, Michał, Banecka-Majkutewicz, Zyta, Węgrzyn, Alicja, Banecki, Bogdan, Kędzierska, Barbara, Lica, Jan   +6 more
core  

Thymidilate Synthase and Methionine Synthase Polymorphisms in Children with Acute Lymphoblastic Leukemia in Western Iran [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2010
Introduction: Polymorphism in genes involved in folate metabolism may cotribute to the susceptibility to acute lymphoblastic leukemia (ALL). Patients and Methods: To examine the influence of polymorphism in thymidylate synthase (TS 28-bp repeat) and ...
Zohreh Rahimi, Zainab Ahmadian, Reza Akramipour, Hamid Madani, Hadi Mozafari, Asad Vaisi-Raygani, Ali Shahriari-Ahmadi   +6 more
doaj   +1 more source

Proteomic Characterization of Armillaria mellea Reveals Oxidative Stress Response Mechanisms and Altered Secondary Metabolism Profiles

Microorganisms, 2017
Armillaria mellea is a major plant pathogen. Yet, the strategies the organism uses to infect susceptible species, degrade lignocellulose and other plant material and protect itself against plant defences and its own glycodegradative arsenal are largely ...
Cassandra Collins, Rachel Hurley, Nada Almutlaqah, Grainne O’Keeffe, Thomas M. Keane, David A. Fitzpatrick, Rebecca A. Owens   +6 more
doaj   +1 more source

Metabolites of ethanol as markers of alcohol abuse : glutathione consumption and methionine kinetics in humans [PDF]

, 2004
In the course of the present doctoral studies two projects related to research in alcoholism and relevant for the postgraduate formation of a pharmacist were pursued: one project dealt with the development of analytical tools applicable to the ...
Schmid, Andreas Ulrich
core   +1 more source