Results 81 to 90 of about 291,374 (170)

Possible Involvement of Hydrosulfide in B12-Dependent Methyl Group Transfer

Molecules, 2017
Evidence from several fields of investigation lead to the hypothesis that the sulfur atom is involved in vitamin B12-dependent methyl group transfer. To compile the evidence, it is necessary to briefly review the following fields: methylation, the new ...
John I. Toohey
doaj   +1 more source

Methionine synthase as a potential therapeutic target

, 2023
This thesis focuses on the enzyme methionine synthase (MS), which catalyzes methylation of homocysteine to produce methionine. Two main families of these enzymes are recognized in nature - cobalamin-dependent and cobalamin-independent.
Kellovská, Kristýna
core  

Palm tocotrienol-rich fraction inhibits methionine-induced cystathionine β-synthase in rat liver

, 2015
Oxidative stress plays an important role in cardiovascular diseases. The study investigated the effects of dietary palm tocotrienol-rich fraction on homocysteine metabolism in rats fed a high-methionine diet.
Nonan, Mohd Rizal, Ayob, Azizi, Kamisah, Yusof, Othman, Faizah, Ku Zaifah, Norsidah, Ahmad Yusof, Asmadi, Asmadi, Ahmad Yusof   +6 more
core  

Human Methionine Synthase [PDF]

Journal of Biological Chemistry, 1997
Linda H. Chen, Mei-Lan Liu, Hye-Yeon Hwang, Li-Sheng Chen, Julie Korenberg, Barry Shane   +5 more
openaire   +1 more source

Dietary methionine depletion and hydrogen sulfide‐producing genes in perivascular adipose tissue of male Wistar rats

Physiological Reports
Perivascular adipose tissue (PVAT) regulates vascular tone, and high‐fat diets reportedly lead to the loss of its anti‐contractile properties. Methionine restriction recapitulates many caloric restriction metabolic effects and increases liver expression ...
Adam Corken, Davis Lee, Elizabeth C. Wahl, James D. Sikes, Keshari M. Thakali   +4 more
doaj   +1 more source

Salmonella Typhimurium vitamin B12-dependent methionine metabolism regulates Caenorhabditis elegans development and vitellogenesis

Microbiology Spectrum
Host-microbe interactions extend beyond infection, involving microbial metabolites, such as short-chain fatty acids, vitamins, and other bioactive compounds, that influence host physiology and development. Using Caenorhabditis elegans, an excellent model
Chamjailiu Daimai, Vidya Devi Negi
doaj   +1 more source

Purification and characterization of mammalian methionine synthase and its reductive activation proteins

, 1998
Methionine synthase is one of two known mammalian enzymes that use vitamin B12 as a cofactor. It catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to generate methionine and tetrahydrofolate.
Chen, Zhiqiang
core  

Structure of full-length cobalamin-dependent methionine synthase and cofactor loading captured in crystallo. [PDF]

Nat Commun, 2023
Mendoza J, Purchal M, Yamada K, Koutmos M.   +3 more
europepmc   +1 more source

Posttranscriptional Regulation of Mammalian Methionine Synthase by B\u3csub\u3e12\u3c/sub\u3e [PDF]

, 1999
Methionine synthase is one of two key enzymes involved in the removal of the metabolite, homocysteine. Elevated homocysteine levels constitute a risk factor for cardiovascular diseases and for neural tube defects.
Banerjee, Ruma V., Gulati, Sumedha, Brody, Lawrence C.   +2 more
core  

Cobalt-Sulfur Coordination Chemistry Drives B₁₂ Loading onto Methionine Synthase. [PDF]

J Am Chem Soc, 2023
Mascarenhas R, Guha A, Li Z, Ruetz M, An S, Seravalli J, Banerjee R.   +6 more
europepmc   +1 more source