Conformational switching and flexibility in cobalamin-dependent methionine synthase studied by small-angle X-ray scattering and cryoelectron microscopy. [PDF]
Watkins MB, Wang H, Burnim A, Ando N.
europepmc +1 more source
Methionine synthase is essential for cancer cell proliferation in physiological folate environments. [PDF]
Sullivan MR +10 more
europepmc +1 more source
Vitamin B12-auxotrophy in dinoflagellates caused by incomplete or absent cobalamin-independent methionine synthase genes (metE). [PDF]
Lin S, Hu Z, Song X, Gobler CJ, Tang YZ.
europepmc +1 more source
Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus. [PDF]
Jeandel M +8 more
europepmc +1 more source
Heterogeneity in cblG : differential binding of vitamin B12 to methionine synthase
Fibroblasts from patients with functional methionine synthase deficiency can be divided into 2 complementation classes, cblE and cblG. Both have low levels of intracellular methylcobalamin.
Sillaots, Susan L. (Susan Linda)
core
Nitrous oxide produced by denitrifying pseudomonads inhibits the growth of rhizosphere bacteria by inactivating the cobalamin-dependent methionine synthase. [PDF]
Wasson PA, McRose DL.
europepmc +1 more source
Molecular Insight into the Effect of a Single-Nucleotide Polymorphic Variation on the Structure and Dynamics of Methionine Synthase Reductase and Its Association with Neural Tube Defects. [PDF]
Sadhukhan S +8 more
europepmc +1 more source
SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism. [PDF]
Matmat K +20 more
europepmc +1 more source
Interactome of methionine synthase and compartmentalization of methionine synthesis
The regulation of gene expression depends on epigenetic modifications of nucleic acids and histones. The most studied modification is the methylation that requires S-adenosyl-methionine (SAM) as methyl donor. This crucial metabolite is a product of the one-carbon metabolism, where methionine synthase (MS) plays a central role at the crossroad of folate
openaire +1 more source

